Antibody Affinity

"Antibody Affinity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.

Descriptor ID	D000915
MeSH Number(s)	G12.040 G12.122.125
Concept/Terms	Antibody Affinity Antibody Affinity Affinity, Antibody Affinities, Antibody Antibody Affinities Antibody Avidity Antibody Avidity Antibody Avidities Avidities, Antibody Avidity, Antibody

Below are MeSH descriptors whose meaning is more general than "Antibody Affinity".

Biological Sciences [G]
Immune System Phenomena [G12]
Antibody Affinity [G12.040]
Antigen-Antibody Reactions [G12.122]
Antibody Affinity [G12.122.125]

Below are MeSH descriptors whose meaning is related to "Antibody Affinity".

Below are MeSH descriptors whose meaning is more specific than "Antibody Affinity".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antibody Affinity" by people in this website by year, and whether "Antibody Affinity" was a major or minor topic of these publications.

Bar chart showing 26 publications over 15 distinct years, with a maximum of 4 publications in 1995

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	2	2	4
1998	1	0	1
2000	0	2	2
2001	0	1	1
2002	0	1	1
2004	1	2	3
2007	0	1	1
2008	1	1	2
2009	1	2	3
2010	1	0	1
2011	0	2	2
2012	0	1	1
2017	1	1	2
2018	0	1	1
2019	0	1	1

Below are the most recent publications written about "Antibody Affinity" by people in Profiles.

Bournazos S, DiLillo DJ, Goff AJ, Glass PJ, Ravetch JV. Differential requirements for Fc?R engagement by protective antibodies against Ebola virus. Proc Natl Acad Sci U S A. 2019 10 01; 116(40):20054-20062.

View in: PubMed
Domeier PP, Chodisetti SB, Schell SL, Kawasawa YI, Fasnacht MJ, Soni C, Rahman ZSM. B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells. Cell Rep. 2018 07 10; 24(2):406-418.

View in: PubMed
Lewin ER, Dasgupta A, Valdes R, Stickle DF. Model analysis of bidirectional interference in two-stage labeled-ligand immunoassays. Clin Biochem. 2017 Dec; 50(18):1188-1197.

View in: PubMed
Wang TT, Sewatanon J, Memoli MJ, Wrammert J, Bournazos S, Bhaumik SK, Pinsky BA, Chokephaibulkit K, Onlamoon N, Pattanapanyasat K, Taubenberger JK, Ahmed R, Ravetch JV. IgG antibodies to dengue enhanced for Fc?RIIIA binding determine disease severity. Science. 2017 01 27; 355(6323):395-398.

View in: PubMed
Anthony RM, Wermeling F, Ravetch JV. Novel roles for the IgG Fc glycan. Ann N Y Acad Sci. 2012 Apr; 1253:170-80.

View in: PubMed
Li F, Ravetch JV. Inhibitory Fc? receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011 Aug 19; 333(6045):1030-4.

View in: PubMed
Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, Marks JD, Adams GP. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Cancer Res. 2011 Mar 15; 71(6):2250-9.

View in: PubMed
Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010 Sep 30; 467(7315):591-5.

View in: PubMed
Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biol Ther. 2009 Nov; 8(22):2147-52.

View in: PubMed
Cenna J, Hunter M, Tan GS, Papaneri AB, Ribka EP, Schnell MJ, Marx PA, McGettigan JP. Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates. J Infect Dis. 2009 Oct 15; 200(8):1251-60.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement