Astrocytes

"Astrocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Descriptor ID	D001253
MeSH Number(s)	A08.637.200 A11.650.200
Concept/Terms	Astrocytes Astrocytes Astrocyte Astroglia Astroglias

Below are MeSH descriptors whose meaning is more general than "Astrocytes".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Astrocytes [A08.637.200]
Cells [A11]
Neuroglia [A11.650]
Astrocytes [A11.650.200]

Below are MeSH descriptors whose meaning is related to "Astrocytes".

Below are MeSH descriptors whose meaning is more specific than "Astrocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Astrocytes" by people in this website by year, and whether "Astrocytes" was a major or minor topic of these publications.

Bar chart showing 149 publications over 29 distinct years, with a maximum of 11 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	4	0	4
1997	2	0	2
1998	0	1	1
1999	1	1	2
2000	0	1	1
2001	1	2	3
2002	4	1	5
2003	1	0	1
2004	6	2	8
2005	4	3	7
2006	2	2	4
2007	1	5	6
2008	6	2	8
2009	4	3	7
2010	2	2	4
2011	6	4	10
2012	3	5	8
2013	4	7	11
2014	7	1	8
2015	5	5	10
2016	2	1	3
2017	5	1	6
2018	3	3	6
2019	5	1	6
2020	3	1	4
2021	4	0	4
2022	3	1	4
2024	2	3	5
2025	0	1	1

Below are the most recent publications written about "Astrocytes" by people in Profiles.

Khalife MR, Villarin C, Ruiz JM, McClelland SA, Rabbo KA, Matthew Mahoney J, Scott RC, Hernan AE. Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins after Early Life Seizures. eNeuro. 2025 Mar; 12(3).

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Smith C, Telesford KM, Piccirillo SGM, Licon-Munoz Y, Zhang W, Tse KM, Rivas JR, Joshi C, Shah DS, Wu AX, Trivedi R, Christley S, Qian Y, Cowell LG, Scheuermann RH, Stowe AM, Nguyen L, Greenberg BM, Monson NL. Astrocytic stress response is induced by exposure to astrocyte-binding antibodies expressed by plasmablasts from pediatric patients with acute transverse myelitis. J Neuroinflammation. 2024 Jun 24; 21(1):161.

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Alizadeh SD, Jalalifar MR, Ghodsi Z, Sadeghi-Naini M, Malekzadeh H, Rahimi G, Mojtabavi K, Shool S, Eskandari Z, Masoomi R, Kiani S, Harrop J, Rahimi-Movaghar V. Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review. Spinal Cord. 2024 04; 62(4):133-142.

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Elder GA, Gama Sosa MA, De Gasperi R, Perez Garcia G, Perez GM, Abutarboush R, Kawoos U, Zhu CW, Janssen WGM, Stone JR, Hof PR, Cook DG, Ahlers ST. The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma. Int J Mol Sci. 2024 Jan 17; 25(2).

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Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 2024 Jan 15; 12.

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Jensen BK. Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression. Adv Neurobiol. 2024; 39:285-318.

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Zhang W, Xiao D, Li X, Zhang Y, Rasouli J, Casella G, Boehm A, Hwang D, Ishikawa LL, Thome R, Ciric B, Curtis MT, Rostami A, Zhang GX. SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity. J Clin Invest. 2022 11 15; 132(22).

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Dong Z, Zhan T, Sun H, Wang J, Duan G, Zhang Y, Chen Y, Huang Y, Xu S. Astrocytic ERK/STAT1 Signaling Contributes to Maintenance of Stress-Related Visceral Hypersensitivity in Rats. J Pain. 2022 11; 23(11):1973-1988.

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Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P. Targeting TNFa produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. Glia. 2022 07; 70(7):1426-1449.

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Allahyari RV, Heinsinger NM, Hwang D, Jaffe DA, Rasouli J, Shiers S, Thomas SJ, Price TJ, Rostami A, Lepore AC. Response of Astrocyte Subpopulations Following Spinal Cord Injury. Cells. 2022 02 18; 11(4).

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