"Binding Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
| Descriptor ID |
D001665
|
| MeSH Number(s) |
G02.111.570.120
|
| Concept/Terms |
Binding Sites- Binding Sites
- Site, Binding
- Sites, Binding
- Binding Site
- Combining Site
- Combining Sites
- Site, Combining
- Sites, Combining
|
Below are MeSH descriptors whose meaning is more general than "Binding Sites".
Below are MeSH descriptors whose meaning is more specific than "Binding Sites".
This graph shows the total number of publications written about "Binding Sites" by people in this website by year, and whether "Binding Sites" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 5 | 5 |
| 2000 | 0 | 10 | 10 |
| 2001 | 0 | 8 | 8 |
| 2002 | 0 | 40 | 40 |
| 2003 | 0 | 34 | 34 |
| 2004 | 0 | 32 | 32 |
| 2005 | 0 | 28 | 28 |
| 2006 | 0 | 36 | 36 |
| 2007 | 0 | 30 | 30 |
| 2008 | 0 | 19 | 19 |
| 2009 | 0 | 14 | 14 |
| 2010 | 0 | 24 | 24 |
| 2011 | 1 | 17 | 18 |
| 2012 | 0 | 12 | 12 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 3 | 3 |
| 2015 | 1 | 13 | 14 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 5 | 6 |
| 2018 | 0 | 4 | 4 |
| 2019 | 0 | 3 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 4 | 4 |
| 2022 | 0 | 3 | 3 |
| 2024 | 0 | 4 | 4 |
To return to the timeline,
click here.
Below are the most recent publications written about "Binding Sites" by people in Profiles.
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Herbine K, Nayak AR, Temiakov D. Structural basis for substrate binding and selection by human mitochondrial RNA polymerase. Nat Commun. 2024 Aug 20; 15(1):7134.
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Freidel MR, Armen RS. Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike. Viruses. 2024 04 30; 16(5).
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Freidel MR, Vakhariya PA, Sardarni SK, Armen RS. The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein. Viruses. 2024 04 20; 16(4).
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Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M. The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun. 2024 Mar 21; 15(1):2533.
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Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, ?ileikyte J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors. Cell Chem Biol. 2022 12 15; 29(12):1694-1708.e10.
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Lancaster EB, Johnson WH, LeVieux JA, Hardtke HA, Zhang YJ, Whitman CP. A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway. Arch Biochem Biophys. 2023 01 01; 733:109471.
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Arige V, Terry LE, Wagner LE, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI. Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2209267119.
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Lodhi N, Singh R, Rajput SP, Saquib Q. SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection. Int J Mol Sci. 2021 Aug 12; 22(16).
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Guerrero-Santoro J, Khor JM, Açikbas AH, Jaynes JB, Ettensohn CA. Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms. J Biol Chem. 2021 07; 297(1):100901.
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Baas BJ, Medellin BP, LeVieux JA, Erwin K, Lancaster EB, Johnson WH, Kaoud TS, Moreno RY, de Ruijter M, Babbitt PC, Zhang YJ, Whitman CP. Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications. Biochemistry. 2021 06 08; 60(22):1776-1786.