Blood-Brain Barrier

"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

Descriptor ID	D001812
MeSH Number(s)	A07.035 A08.186.211.035
Concept/Terms	Blood-Brain Barrier Blood-Brain Barrier Barrier, Blood-Brain Barriers, Blood-Brain Blood Brain Barrier Blood-Brain Barriers Hemato-Encephalic Barrier Barrier, Hemato-Encephalic Barriers, Hemato-Encephalic Hemato Encephalic Barrier Hemato-Encephalic Barriers Brain-Blood Barrier Barrier, Brain-Blood Barriers, Brain-Blood Brain Blood Barrier Brain-Blood Barriers

Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".

Anatomy [A]
Cardiovascular System [A07]
Blood-Brain Barrier [A07.035]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Blood-Brain Barrier [A08.186.211.035]

Below are MeSH descriptors whose meaning is related to "Blood-Brain Barrier".

Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.

Bar chart showing 121 publications over 25 distinct years, with a maximum of 10 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	2	2	4
2001	1	4	5
2002	1	2	3
2004	1	1	2
2006	2	2	4
2007	5	1	6
2008	3	5	8
2009	1	2	3
2010	3	2	5
2011	2	4	6
2012	5	1	6
2013	2	2	4
2014	2	3	5
2015	2	3	5
2016	2	3	5
2017	3	3	6
2018	8	2	10
2019	4	4	8
2020	4	1	5
2021	2	4	6
2022	1	1	2
2023	2	1	3
2024	4	3	7
2025	0	2	2

Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.

Diamandi J, Raimondo C, Piper K, Roy J, Serva S, Alizadeh M, Flanders A, Tjoumakaris S, Gooch R, Jabbour P, Rosenwasser R, Mouchtouris N. Use of multi-modal non-contrast MRI to predict functional outcomes after stroke: A study using DP-pCASL, DTI, NODDI, and MAP MRI. Neuroimage Clin. 2025; 45:103742.

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Hao H, Yin T, Li T, Zhou X, Ren H, Liu M, Huang H, Qi C, Xiu Y, Qiu W, Wang D, Shi M, Wang X, Dumont AS, Liu Q. Inhibition of Bruton's tyrosine kinase restricts neuroinflammation following intracerebral hemorrhage. Theranostics. 2025; 15(2):494-508.

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Mouchtouris N, Ailes I, Chang K, Flanders A, Mohamed F, Tjoumakaris S, Gooch R, Jabbour P, Rosenwasser R, Alizadeh M. The impact of mechanical thrombectomy on the blood-brain barrier in patients with acute ischemic stroke: A non-contrast MR imaging study using DP-pCASL and NODDI. Neuroimage Clin. 2024; 43:103629.

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Brailoiu E, Barr JL, Wittorf HN, Inan S, Unterwald EM, Brailoiu GC. Modulation of the Blood-Brain Barrier by Sigma-1R Activation. Int J Mol Sci. 2024 May 09; 25(10).

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Arag?n-Gonz?lez A, Shaw AC, Kok JR, Roussel FS, Santos Souza CD, Granger SM, Vetter T, de Diego Y, Meyer KC, Beal SN, Shaw PJ, Ferraiuolo L. C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity. Fluids Barriers CNS. 2024 Apr 11; 21(1):34.

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Zhang SS, Li RQ, Chen Z, Wang XY, Dumont AS, Fan X. Immune cells: potential carriers or agents for drug delivery to the central nervous system. Mil Med Res. 2024 Mar 29; 11(1):19.

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Mouchtouris N, Ailes I, Gooch R, Raimondo C, Oghli YS, Tjoumakaris S, Jabbour P, Rosenwasser R, Alizadeh M. Quantifying blood-brain barrier permeability in patients with ischemic stroke using non-contrast MRI. Magn Reson Imaging. 2024 Jun; 109:165-172.

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Kaur M, Fusco S, Van den Broek B, Aseervatham J, Rostami A, Iacovitti L, Grassi C, Lukomska B, Srivastava AK. Most recent advances and applications of extracellular vesicles in tackling neurological challenges. Med Res Rev. 2024 07; 44(4):1923-1966.

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Acharya NK, Grossman HC, Clifford PM, Levin EC, Light KR, Choi H, Swanson Ii RL, Kosciuk MC, Venkataraman V, Libon DJ, Matzel LD, Nagele RG. A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta1-42 Peptide in the Brain and Leads to Alzheimer's Disease-Relevant Cognitive Changes in a Mouse Model. J Alzheimers Dis. 2024; 98(1):163-186.

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Leal AF, Inci OK, Seyrantepe V, Rintz E, Celik B, Ago Y, Le?n D, Suarez DA, Alm?ciga-D?az CJ, Tomatsu S. Molecular Trojan Horses for treating lysosomal storage diseases. Mol Genet Metab. 2023 11; 140(3):107648.

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