A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)

Descriptor ID	D002549
MeSH Number(s)	C10.114.375.112 C10.228.140.400 C10.228.140.695.562.112 C10.314.350.112 C20.111.258.250.175
Concept/Terms	Diffuse Cerebral Sclerosis of Schilder Diffuse Cerebral Sclerosis of Schilder Encephalitis Periaxialis Encephalitis Periaxialis Concentrica Sudanophilic Cerebral Sclerosis Myelinoclastic Diffuse Sclerosis Diffuse Scleroses, Myelinoclastic Diffuse Sclerosis, Myelinoclastic Myelinoclastic Diffuse Scleroses Scleroses, Myelinoclastic Diffuse Sclerosis, Myelinoclastic Diffuse Poliodystrophia Cerebri Schilder Disease Disease, Schilder Schilder's Disease Disease, Schilder's Schilders Disease Cerebral Sclerosis, Diffuse Diffuse Cerebral Scleroses Diffuse Cerebral Sclerosis Sclerosis, Diffuse Cerebral Encephalitis Periaxialis Diffusa Balo Concentric Sclerosis Balo Concentric Sclerosis Concentric Sclerosis, Balo Balo's Concentric Sclerosis Concentric Sclerosis, Balo's Scleroses, Balo's Concentric Alpers Syndrome Alpers Syndrome Syndrome, Alpers Alpers Disease Alpers Progressive Infantile Poliodystrophy Progressive Sclerosing Poliodystrophy Progressive Sclerosing Poliodystrophies Alpers' Syndrome Alper Syndrome Alper's Syndrome Alpers-Huttenlocher Syndrome Alpers Huttenlocher Syndrome Syndrome, Alpers-Huttenlocher Neuronal Degeneration Of Childhood With Liver Disease, Progressive Progressive Neuronal Degeneration of Childhood with Liver Disease Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis Alpers' Disease Alper Disease Alper's Disease Disease, Alpers'

Below are MeSH descriptors whose meaning is more general than "Diffuse Cerebral Sclerosis of Schilder".

Below are MeSH descriptors whose meaning is related to "Diffuse Cerebral Sclerosis of Schilder".

Below are MeSH descriptors whose meaning is more specific than "Diffuse Cerebral Sclerosis of Schilder".