"Cerebroside-Sulfatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.
Descriptor ID |
D002553
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MeSH Number(s) |
D08.811.277.352.827.070.250
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Concept/Terms |
Cerebroside-Sulfatase- Cerebroside-Sulfatase
- Cerebroside Sulfatase
- Sulfatidate Sulfatase
- Sulfatase, Sulfatidate
- Arylsulfatase A
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Below are MeSH descriptors whose meaning is more general than "Cerebroside-Sulfatase".
Below are MeSH descriptors whose meaning is more specific than "Cerebroside-Sulfatase".
This graph shows the total number of publications written about "Cerebroside-Sulfatase" by people in this website by year, and whether "Cerebroside-Sulfatase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cerebroside-Sulfatase" by people in Profiles.
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Luzi P, Rafi MA, Rao HZ, Wenger DA. Sixteen novel mutations in the arylsulfatase A gene causing metachromatic leukodystrophy. Gene. 2013 Nov 10; 530(2):323-8.
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Rafi MA, Coppola S, Liu SL, Rao HZ, Wenger DA. Disease-causing mutations in cis with the common arylsulfatase A pseudodeficiency allele compound the difficulties in accurately identifying patients and carriers of metachromatic leukodystrophy. Mol Genet Metab. 2003 Jun; 79(2):83-90.
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Pastor-Soler NM, Rafi MA, Hoffman JD, Hu D, Wenger DA. Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene. Hum Mutat. 1994; 4(3):199-207.
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Rafi MA, Amini S, Zhang XL, Wenger DA. Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured cells from a patient with SAP-1 deficiency. Am J Hum Genet. 1992 Jun; 50(6):1252-8.
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Louie E, Rafi MA, Wenger DA. Leukocyte sonicates as a source for both enzyme assay and DNA amplification for mutational analysis of certain lysosomal disorders. Clin Chim Acta. 1991 May 31; 199(1):7-15.