Colorectal Neoplasms, Hereditary Nonpolyposis

"Colorectal Neoplasms, Hereditary Nonpolyposis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Descriptor ID	D003123
MeSH Number(s)	C04.588.274.476.411.307.190 C04.700.250 C06.301.371.411.307.190 C06.405.249.411.307.190 C06.405.469.158.356.190 C06.405.469.491.307.190 C16.320.700.250 C18.452.284.255
Concept/Terms	Colorectal Neoplasms, Hereditary Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Cancer Colorectal Cancer Hereditary Nonpolyposis Lynch Syndrome I Lynch Cancer Family Syndrome I Lynch Syndrome Syndrome, Lynch Colon Cancer, Familial Nonpolyposis Hereditary Nonpolyposis Colon Cancer

Below are MeSH descriptors whose meaning is more general than "Colorectal Neoplasms, Hereditary Nonpolyposis".

Diseases [C]
Neoplasms [C04]
Neoplasms by Site [C04.588]
Digestive System Neoplasms [C04.588.274]
Gastrointestinal Neoplasms [C04.588.274.476]
Intestinal Neoplasms [C04.588.274.476.411]
Colorectal Neoplasms [C04.588.274.476.411.307]
Colorectal Neoplasms, Hereditary Nonpolyposis [C04.588.274.476.411.307.190]
Neoplastic Syndromes, Hereditary [C04.700]
Colorectal Neoplasms, Hereditary Nonpolyposis [C04.700.250]
Digestive System Diseases [C06]
Digestive System Neoplasms [C06.301]
Gastrointestinal Neoplasms [C06.301.371]
Intestinal Neoplasms [C06.301.371.411]
Colorectal Neoplasms [C06.301.371.411.307]
Colorectal Neoplasms, Hereditary Nonpolyposis [C06.301.371.411.307.190]
Gastrointestinal Diseases [C06.405]
Gastrointestinal Neoplasms [C06.405.249]
Intestinal Neoplasms [C06.405.249.411]
Colorectal Neoplasms [C06.405.249.411.307]
Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.249.411.307.190]
Intestinal Diseases [C06.405.469]
Colonic Diseases [C06.405.469.158]
Colorectal Neoplasms [C06.405.469.158.356]
Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.158.356.190]
Intestinal Neoplasms [C06.405.469.491]
Colorectal Neoplasms [C06.405.469.491.307]
Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.491.307.190]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Neoplastic Syndromes, Hereditary [C16.320.700]
Colorectal Neoplasms, Hereditary Nonpolyposis [C16.320.700.250]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
DNA Repair-Deficiency Disorders [C18.452.284]
Colorectal Neoplasms, Hereditary Nonpolyposis [C18.452.284.255]

Below are MeSH descriptors whose meaning is related to "Colorectal Neoplasms, Hereditary Nonpolyposis".

Below are MeSH descriptors whose meaning is more specific than "Colorectal Neoplasms, Hereditary Nonpolyposis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in this website by year, and whether "Colorectal Neoplasms, Hereditary Nonpolyposis" was a major or minor topic of these publications.

Bar chart showing 17 publications over 13 distinct years, with a maximum of 3 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	2	0	2
1997	1	0	1
1998	1	0	1
1999	2	1	3
2001	1	0	1
2002	1	1	2
2003	0	1	1
2004	1	0	1
2010	1	0	1
2011	1	0	1
2020	1	0	1
2021	1	0	1

Below are the most recent publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Profiles.

Raygada M, Raffeld M, Bernstein A, Miettinen M, Glod J, Hughes MS, Reilly K, Widemann B, Del Rivero J. Case report of adrenocortical carcinoma associated with double germline mutations in MSH2 and RET. Am J Med Genet A. 2021 04; 185(4):1282-1287.

View in: PubMed
Dondi G, Coluccelli S, De Leo A, Ferrari S, Gruppioni E, Bovicelli A, Godino L, Coada CA, Morganti AG, Giordano A, Santini D, Ceccarelli C, Turchetti D, De Iaco P, Perrone AM. An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach. Int J Mol Sci. 2020 Sep 29; 21(19).

View in: PubMed
Hassen S, Boman BM, Ali N, Parker M, Somerman C, Ali-Khan Catts ZJ, Ali AA, Fields JZ. Detection of DNA mismatch repair proteins in fresh human blood lymphocytes--towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening. J Exp Clin Cancer Res. 2011 Oct 21; 30:100.

View in: PubMed
Manne SL, Meropol NJ, Weinberg DS, Vig H, Ali-Khan Catts Z, Manning C, Ross E, Shannon K, Chung DC. Facilitating informed decisions regarding microsatellite instability testing among high-risk individuals diagnosed with colorectal cancer. J Clin Oncol. 2010 Mar 10; 28(8):1366-72.

View in: PubMed
Fields JZ, Gao Z, Gao Z, Lewis M, Maimonis P, Harvey J, Lynch HT, Boman BM. Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancer. J Lab Clin Med. 2004 Jan; 143(1):59-66.

View in: PubMed
Cutler NS, Graves-Deal R, LaFleur BJ, Gao Z, Boman BM, Whitehead RH, Terry E, Morrow JD, Coffey RJ. Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. Cancer Res. 2003 Apr 15; 63(8):1748-51.

View in: PubMed
Palazzo JP, Edmonston TB, Chaille-Arnold LM, Burkholder S. Invasive papillary adenocarcinoma of the colon. Hum Pathol. 2002 Mar; 33(3):372-5.

View in: PubMed
Müller A, Edmonston TB, Corao DA, Rose DG, Palazzo JP, Becker H, Fry RD, Rueschoff J, Fishel R. Exclusion of breast cancer as an integral tumor of hereditary nonpolyposis colorectal cancer. Cancer Res. 2002 Feb 15; 62(4):1014-9.

View in: PubMed
Lee JS, Petrelli NJ, Rodriguez-Bigas MA. Rectal cancer in hereditary nonpolyposis colorectal cancer. Am J Surg. 2001 Mar; 181(3):207-10.

View in: PubMed
Weber TK, Chin HM, Rodriguez-Bigas M, Keitz B, Gilligan R, O'Malley L, Urf E, Diba N, Pazik J, Petrelli NJ. Novel hMLH1 and hMSH2 germline mutations in African Americans with colorectal cancer. JAMA. 1999 Jun 23-30; 281(24):2316-20.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement