"Complement C5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003182
|
| MeSH Number(s) |
D12.776.124.486.274.450
|
| Concept/Terms |
Complement C5- Complement C5
- C5, Complement
- C5 Complement
- Complement, C5
- Complement 5
- Complement Component 5
- Component 5, Complement
Complement C5, Precursor- Complement C5, Precursor
- C5, Precursor Complement
- Precursor Complement C5
- Pro-C5
- Pro C5
- Pro-complement 5
- Pro complement 5
- Precursor C5
- C5, Precursor
|
Below are MeSH descriptors whose meaning is more general than "Complement C5".
Below are MeSH descriptors whose meaning is more specific than "Complement C5".
This graph shows the total number of publications written about "Complement C5" by people in this website by year, and whether "Complement C5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C5" by people in Profiles.
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Inan S, Ward SJ, Baltazar CT, Peruggia GA, Javed E, Nayak AP. Epicutaneous Sensitization to the Phytocannabinoid ?-Caryophyllene Induces Pruritic Inflammation. Int J Mol Sci. 2023 Sep 20; 24(18).
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Mahmoudzadeh R, Hinkle JW, Hsu J, Garg SJ. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 01; 32(3):294-300.
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Kerepesi LA, Hess JA, Nolan TJ, Schad GA, Abraham D. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol. 2006 Apr 1; 176(7):4315-22.
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Yancey KB, Bielory L, Wright R, Young N, Frank MM, Lawley TJ. Patients with bone marrow failure demonstrate decreased cutaneous reactivity to human C5a. J Invest Dermatol. 1987 Apr; 88(4):388-92.