Cystine

"Cystine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.

Descriptor ID	D003553
MeSH Number(s)	D01.248.497.158.874.390.369 D01.875.350.850.150.369 D02.886.030.230.369 D02.886.520.150.087 D12.125.095.369 D12.125.119.369 D12.125.166.230.369
Concept/Terms	Cystine Cystine L-Cystine L Cystine Copper Cystinate Copper Cystinate

Below are MeSH descriptors whose meaning is more general than "Cystine".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Electrolytes [D01.248]
Ions [D01.248.497]
Anions [D01.248.497.158]
Sulfides [D01.248.497.158.874]
Disulfides [D01.248.497.158.874.390]
Cystine [D01.248.497.158.874.390.369]
Sulfur Compounds [D01.875]
Hydrogen Sulfide [D01.875.350]
Sulfides [D01.875.350.850]
Disulfides [D01.875.350.850.150]
Cystine [D01.875.350.850.150.369]
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Amino Acids, Sulfur [D02.886.030]
Cysteine [D02.886.030.230]
Cystine [D02.886.030.230.369]
Sulfides [D02.886.520]
Disulfides [D02.886.520.150]
Cystine [D02.886.520.150.087]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Diamino [D12.125.095]
Cystine [D12.125.095.369]
Amino Acids, Dicarboxylic [D12.125.119]
Cystine [D12.125.119.369]
Amino Acids, Sulfur [D12.125.166]
Cysteine [D12.125.166.230]
Cystine [D12.125.166.230.369]

Below are MeSH descriptors whose meaning is related to "Cystine".

Below are MeSH descriptors whose meaning is more specific than "Cystine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cystine" by people in this website by year, and whether "Cystine" was a major or minor topic of these publications.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1994 and 2003 and 2007 and 2008 and 2013 and 2015 and 2016 and 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
2003	1	0	1
2007	1	0	1
2008	1	0	1
2013	0	1	1
2015	0	1	1
2016	1	0	1
2018	1	0	1
2019	1	0	1

Below are the most recent publications written about "Cystine" by people in Profiles.

Watson WH, Ritzenthaler JD, Peyrani P, Wiemken TL, Furmanek S, Reyes Vega AM, Burke TJ, Zheng Y, Ramirez JA, Roman J. Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients. Free Radic Biol Med. 2019 11 01; 143:55-61.

View in: PubMed
Zheng Y, Ritzenthaler JD, Burke TJ, Otero J, Roman J, Watson WH. Age-dependent oxidation of extracellular cysteine/cystine redox state (Eh(Cys/CySS)) in mouse lung fibroblasts is mediated by a decline in Slc7a11 expression. Free Radic Biol Med. 2018 04; 118:13-22.

View in: PubMed
Watson WH, Burke TJ, Zelko IN, Torres-González E, Ritzenthaler JD, Roman J. Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice. Oxid Med Cell Longev. 2016; 2016:1561305.

View in: PubMed
Stephenson ST, Brown LA, Helms MN, Qu H, Brown SD, Brown MR, Fitzpatrick AM. Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma. J Allergy Clin Immunol. 2015 Aug; 136(2):454-61.e9.

View in: PubMed
Lee GB, Brandt EB, Xiao C, Gibson AM, Le Cras TD, Brown LA, Fitzpatrick AM, Khurana Hershey GK. Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma. PLoS One. 2013; 8(3):e60632.

View in: PubMed
Iyer SS, Ramirez AM, Ritzenthaler JD, Torres-Gonzalez E, Roser-Page S, Mora AL, Brigham KL, Jones DP, Roman J, Rojas M. Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis. . 2009 Jan; 296(1):L37-45.

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Ramirez A, Ramadan B, Ritzenthaler JD, Rivera HN, Jones DP, Roman J. Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L972-81.

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Raje S, Thorpe C. Inter-domain redox communication in flavoenzymes of the quiescin/sulfhydryl oxidase family: role of a thioredoxin domain in disulfide bond formation. Biochemistry. 2003 Apr 22; 42(15):4560-8.

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Charnas LR, Luciano CA, Dalakas M, Gilliatt RW, Bernardini I, Ishak K, Cwik VA, Fraker D, Brushart TA, Gahl WA. Distal vacuolar myopathy in nephropathic cystinosis. Ann Neurol. 1994 Feb; 35(2):181-8.

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Gahl WA, Charnas L, Markello TC, Bernardini I, Ishak KG, Dalakas MC. Parenchymal organ cystine depletion with long-term cysteamine therapy. Biochem Med Metab Biol. 1992 Dec; 48(3):275-85.

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