Dactinomycin

"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Descriptor ID	D003609
MeSH Number(s)	D03.633.300.200 D04.345.566.252 D12.644.641.252
Concept/Terms	Dactinomycin Dactinomycin Meractinomycin Actinomycin D Actinomycin Actinomycin Cosmegen Cosmegen Cosmegen Lyovac Lyovac, Cosmegen Lyovac-Cosmegen Lyovac Cosmegen LyovacCosmegen

Below are MeSH descriptors whose meaning is more general than "Dactinomycin".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 3-Ring [D03.633.300]
Dactinomycin [D03.633.300.200]
Polycyclic Compounds [D04]
Macrocyclic Compounds [D04.345]
Peptides, Cyclic [D04.345.566]
Dactinomycin [D04.345.566.252]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptides, Cyclic [D12.644.641]
Dactinomycin [D12.644.641.252]

Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1999 and 2003 and 2004 and 2007 and 2009 and 2012 and 2014 and 2022

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1999	1	1
2003	1	1
2004	1	1
2007	1	1
2009	1	1
2012	1	1
2014	1	1
2022	1	1

Below are the most recent publications written about "Dactinomycin" by people in Profiles.

Kube P, Parisio K, Mangum DS, Powell J. Fusion-negative rhabdomyosarcoma with diffuse bony metastases and remarkable chemosensitivity. BMJ Case Rep. 2022 Aug 29; 15(8).

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Ashton E, Szutowska M, Shafer A, Hoffman J. Attempted conservative management of a placental site trophoblastic tumor: a case report. Conn Med. 2014 Sep; 78(8):475-7.

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Schmidt J, Barthel K, Zschüntzsch J, Muth IE, Swindle EJ, Hombach A, Sehmisch S, Wrede A, Lühder F, Gold R, Dalakas MC. Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1ß-induced accumulation of ß-amyloid and cell death. Brain. 2012 Apr; 135(Pt 4):1102-14.

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Arndt CA, Stoner JA, Hawkins DS, Rodeberg DA, Hayes-Jordan AA, Paidas CN, Parham DM, Teot LA, Wharam MD, Breneman JC, Donaldson SS, Anderson JR, Meyer WH. Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803. J Clin Oncol. 2009 Nov 01; 27(31):5182-8.

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Golkar L, Ding XZ, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, Fought AJ, Bentrem DJ, Talamonti MS, Bell RH, Adrian TE. Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1. J Surg Res. 2007 Apr; 138(2):163-9.

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Suon S, Jin H, Donaldson AE, Caterson EJ, Tuan RS, Deschennes G, Marshall C, Iacovitti L. Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms. Stem Cells Dev. 2004 Dec; 13(6):625-35.

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Blakely ML, Andrassy RJ, Raney RB, Anderson JR, Wiener ES, Rodeberg DA, Paidas CN, Lobe TE, Crist WM. Prognostic factors and surgical treatment guidelines for children with rhabdomyosarcoma of the perineum or anus: a report of Intergroup Rhabdomyosarcoma Studies I through IV, 1972 through 1997. J Pediatr Surg. 2003 Mar; 38(3):347-53.

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Moran J, Itoh T, Reddy UR, Chen M, Alnemri ES, Pleasure D. Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP. J Neurochem. 1999 Aug; 73(2):568-77.

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