"Dantrolene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
| Descriptor ID |
D003620
|
| MeSH Number(s) |
D03.383.129.308.432.555.287
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dantrolene".
Below are MeSH descriptors whose meaning is more specific than "Dantrolene".
This graph shows the total number of publications written about "Dantrolene" by people in this website by year, and whether "Dantrolene" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dantrolene" by people in Profiles.
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Vera R, Hong N, Jiang B, Liang G, Eckenhoff MF, Kincaid HJ, Browne V, Chellaraj V, Gisewhite D, Greenberg M, Ranjan S, Zhu G, Wei H. Effects of Intranasal Dantrolene Nanoparticles on Brain Concentration and Behavior in PS19 Tau Transgenic Mice. J Alzheimers Dis. 2024; 98(2):549-562.
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Robinson VM, Alsalahat I, Freeman S, Antzelevitch C, Barajas-Martinez H, Venetucci L. A carvedilol analogue, VK-II-86, prevents hypokalaemia-induced ventricular arrhythmia through novel multi-channel effects. Br J Pharmacol. 2022 06; 179(11):2713-2732.
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Litman RS, Smith VI, Larach MG, Mayes L, Shukry M, Theroux MC, Watt S, Wong CA. Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia. Anesth Analg. 2019 04; 128(4):652-659.
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Delfiner MS, Nofi C, Li Y, Gerdes AM, Zhang Y. Failing Hearts Are More Vulnerable to Sympathetic, but Not Vagal Stimulation-Induced, Atrial Fibrillation-Ameliorated with Dantrolene Treatment. J Card Fail. 2018 Jul; 24(7):460-469.
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MacKay EJ, Wilkerson C, Kraeva N, Rosenberg H, Kennedy T. A rare genetic variant of the ryanodine receptor in a suspected malignant hyperthermia susceptible patient. J Clin Anesth. 2016 Sep; 33:144-6.
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Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 Jul 11; 575:7-12.
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Schreiber AL, Vasudevan JM, Fetouh SK, Ankam NS, Hussain A, Rakocevic G. Atypical clinically diagnosed stiff-person syndrome response to dantrolene--a refractory case. Muscle Nerve. 2012 Mar; 45(3):454-5.
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Whyte J, Katz D, Long D, DiPasquale MC, Polansky M, Kalmar K, Giacino J, Childs N, Mercer W, Novak P, Maurer P, Eifert B. Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study. Arch Phys Med Rehabil. 2005 Mar; 86(3):453-62.