Drug Evaluation, Preclinical

"Drug Evaluation, Preclinical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

Descriptor ID	D004353
MeSH Number(s)	E05.295.750 E05.337.550
Concept/Terms	Drug Evaluation, Preclinical Drug Evaluation, Preclinical Drug Evaluations, Preclinical Drug Screening Drug Screenings Screening, Drug Screenings, Drug Evaluation Studies, Drug, Pre-Clinical Preclinical Drug Evaluations Evaluation, Preclinical Drug Evaluations, Preclinical Drug Preclinical Drug Evaluation Drug Evaluation Studies, Preclinical Evaluation Studies, Drug, Preclinical Medicinal Plants Testing, Preclinical Medicinal Plants Testing, Preclinical

Below are MeSH descriptors whose meaning is more general than "Drug Evaluation, Preclinical".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Drug Discovery [E05.295]
Drug Evaluation, Preclinical [E05.295.750]
Evaluation Studies as Topic [E05.337]
Drug Evaluation, Preclinical [E05.337.550]

Below are MeSH descriptors whose meaning is related to "Drug Evaluation, Preclinical".

Below are MeSH descriptors whose meaning is more specific than "Drug Evaluation, Preclinical".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Drug Evaluation, Preclinical" by people in this website by year, and whether "Drug Evaluation, Preclinical" was a major or minor topic of these publications.

Bar chart showing 50 publications over 15 distinct years, with a maximum of 9 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	1	1
2004	0	4	4
2005	0	2	2
2006	0	5	5
2007	1	2	3
2008	2	5	7
2009	2	3	5
2010	2	7	9
2011	2	3	5
2012	0	1	1
2013	1	1	2
2015	1	2	3
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "Drug Evaluation, Preclinical" by people in Profiles.

Ott CA, Baljinnyam B, Zakharov AV, Jadhav A, Simeonov A, Zhuang Z. Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol. 2017 09 15; 12(9):2399-2407.

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Oppermann S, Ylanko J, Shi Y, Hariharan S, Oakes CC, Brauer PM, Zúñiga-Pflücker JC, Leber B, Spaner DE, Andrews DW. High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells. Blood. 2016 08 18; 128(7):934-47.

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Chen X, Walther FJ, Sengers RM, Laghmani el H, Salam A, Folkerts G, Pera T, Wagenaar GT. Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 01; 309(3):L262-70.

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Lakkaraju SK, Yu W, Raman EP, Hershfeld AV, Fang L, Deshpande DA, MacKerell AD. Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors. J Chem Inf Model. 2015 Mar 23; 55(3):700-8.

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Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL. Characterization of a novel small molecule that potentiates ß-lactam activity against gram-positive and gram-negative pathogens. Antimicrob Agents Chemother. 2015 Apr; 59(4):1876-85.

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Sorna V, Theisen ER, Stephens B, Warner SL, Bearss DJ, Vankayalapati H, Sharma S. High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors. J Med Chem. 2013 Dec 12; 56(23):9496-508.

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Maurer B, Distler A, Dees C, Khan K, Denton CP, Abraham D, Gay RE, Michel BA, Gay S, Hw Distler J, Distler O. Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis. 2013 Dec; 72(12):2039-46.

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Ji C, Lin W, Moraski GC, Thanassi JA, Pucci MJ, Franzblau SG, Möllmann U, Miller MJ. Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction. Bioorg Med Chem. 2012 Jun 1; 20(11):3422-8.

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Tan GS, Chiu CH, Garchow BG, Metzler D, Diamond SL, Kiriakidou M. Small molecule inhibition of RISC loading. ACS Chem Biol. 2012 Feb 17; 7(2):403-10.

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Jones KB, Haldar M, Schiffman JD, Cannon-Albright L, Lessnick SL, Sharma S, Capecchi MR, Randall RL. Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. Cancer Control. 2011 Jul; 18(3):196-203.

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