Item Type | Name |
Concept
|
Allosteric Regulation
|
Concept
|
Amino Acid Sequence
|
Concept
|
Base Sequence
|
Concept
|
Binding Sites
|
Concept
|
Binding, Competitive
|
Concept
|
Carcinoma, Renal Cell
|
Concept
|
DNA Repair
|
Concept
|
DNA Replication
|
Concept
|
DNA Helicases
|
Concept
|
DNA, Single-Stranded
|
Concept
|
Dihydroxyphenylalanine
|
Concept
|
Escherichia coli
|
Concept
|
Humans
|
Concept
|
Mammals
|
Concept
|
Mice, Inbred C57BL
|
Concept
|
Nucleic Acid Hybridization
|
Concept
|
Poly Adenosine Diphosphate Ribose
|
Concept
|
Poly(ADP-ribose) Polymerases
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Protein Binding
|
Concept
|
Protein Conformation
|
Concept
|
Saccharomyces cerevisiae
|
Concept
|
Spectrometry, Fluorescence
|
Concept
|
Structure-Activity Relationship
|
Concept
|
Transcription, Genetic
|
Concept
|
Translocation, Genetic
|
Concept
|
Apoptosis
|
Concept
|
Mice, Knockout
|
Concept
|
Crystallography, X-Ray
|
Concept
|
BRCA1 Protein
|
Concept
|
DNA Polymerase beta
|
Concept
|
Catalytic Domain
|
Concept
|
Cryoelectron Microscopy
|
Concept
|
3' Untranslated Regions
|
Concept
|
Electrophoretic Mobility Shift Assay
|
Concept
|
Genes, BRCA2
|
Concept
|
BRCA2 Protein
|
Concept
|
RNA, Small Interfering
|
Concept
|
Cell Line, Tumor
|
Concept
|
Cell Proliferation
|
Concept
|
Mice
|
Concept
|
HEK293 Cells
|
Concept
|
DNA End-Joining Repair
|
Concept
|
Recombinational DNA Repair
|
Academic Article
|
Template misalignment in multisubunit RNA polymerases and transcription fidelity.
|
Academic Article
|
A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment.
|
Concept
|
Poly (ADP-Ribose) Polymerase-1
|
Concept
|
Poly(ADP-ribose) Polymerase Inhibitors
|
Concept
|
Poly ADP Ribosylation
|
Academic Article
|
DNA polymerases are error-prone at RecA-mediated recombination intermediates.
|
Academic Article
|
DNA polymerase ? specializes in incorporating synthetic expanded-size (xDNA) nucleotides.
|
Academic Article
|
Modification of 3' Terminal Ends of DNA and RNA Using DNA Polymerase ? Terminal Transferase Activity.
|
Academic Article
|
How RNA transcripts coordinate DNA recombination and repair.
|
Academic Article
|
Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Pol?.
|
Academic Article
|
Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication.
|
Academic Article
|
PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter.
|
Academic Article
|
Molecular basis of microhomology-mediated end-joining by purified full-length Pol?.
|
Academic Article
|
The helicase domain of Pol? counteracts RPA to promote alt-NHEJ.
|
Academic Article
|
Pol? promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining.
|
Academic Article
|
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
|
Academic Article
|
Polymerase ? is a robust terminal transferase that oscillates between three different mechanisms during end-joining.
|
Academic Article
|
Polymerase ?-helicase efficiently unwinds DNA and RNA-DNA hybrids.
|
Academic Article
|
DNA Polymerase ?: A Cancer Drug Target with Reverse Transcriptase Activity.
|
Academic Article
|
Pol? promotes microhomology-mediated end-joining.
|
Academic Article
|
Author Correction: Pol? promotes microhomology-mediated end-joining.
|
Academic Article
|
Correction: Candidate variants in?DNA replication and?repair genes in?early-onset renal cell carcinoma patients referred for?germline testing.
|
Academic Article
|
Genetic separation of Brca1 functions reveal mutation-dependent Pol? vulnerabilities.
|
Academic Article
|
Discovery of a small-molecule inhibitor that traps Pol? on DNA and synergizes with PARP inhibitors.
|
Academic Article
|
PARG is essential for Pol?-mediated DNA end-joining by removing repressive poly-ADP-ribose marks.
|
Academic Article
|
Structural basis for a Pol? helicase small-molecule inhibitor revealed by cryo-EM.
|
Academic Article
|
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.
|