Thomas Jefferson University

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Wiest, David
One or more keywords matched the following items that are connected to Wiest, David
Item TypeName
Concept Antigen-Presenting Cells
Concept Histocompatibility Antigens Class II
Concept Receptors, Antigen, B-Cell
Concept Receptors, Antigen, T-Cell
Concept Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Receptor-CD3 Complex, Antigen, T-Cell
Concept Antigen Presentation
Concept T-Cell Antigen Receptor Specificity
Concept CD24 Antigen
Grant Analysis of pre-TCR Structure and Function
Grant DEVELOPMENTAL CONTROL OF TCR EXPRESSION IN THYMOCYTES
Academic Article Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.
Academic Article Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage.
Academic Article Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.
Academic Article Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.
Academic Article Origins of ?d T cell effector subsets: a riddle wrapped in an enigma.
Academic Article Enforcement of ?d-lineage commitment by the pre-T-cell receptor in precursors with weak ?d-TCR signals.
Academic Article The TCR ligand-inducible expression of CD73 marks ?d lineage commitment and a metastable intermediate in effector specification.
Academic Article Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.
Academic Article Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation.
Academic Article High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.
Academic Article The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells.
Academic Article Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.
Academic Article HEB is required for the specification of fetal IL-17-producing ?d T cells.
Academic Article Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.
Academic Article Development of ?d T Cells, the Special-Force Soldiers of the Immune System.
Academic Article Development of ?d T Cells: Soldiers on the Front Lines of Immune Battles.
Academic Article Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Academic Article Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.
Academic Article Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
Academic Article Early growth response genes regulate B cell development, proliferation, and immune response.
Academic Article T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.
Academic Article Cutting edge: Intrinsic programming of thymic ?dT cells for specific peripheral tissue localization.
Academic Article Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.
Academic Article A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
Academic Article Egr2 is required for Bcl-2 induction during positive selection.
Academic Article Rpl22 Loss Selectively Impairs a? T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.
Academic Article Id3 Restricts ?d NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.
Academic Article Integration of T-cell receptor, Notch and cytokine signals programs mouse ?d T-cell effector differentiation.
Academic Article Noncanonical mode of ERK action controls alternative a? and ?d T cell lineage fates.
Academic Article Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
Academic Article The E protein-TCF1 axis controls ?d T?cell development and effector fate.
Academic Article Identification of the last cog in a ligand-independent signaling machine?
Academic Article TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.
Academic Article Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.
Academic Article Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes ?d T-cell commitment by enhancing TCR signal strength.
Academic Article Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.
Academic Article Role of a selecting ligand in shaping the murine ?d-TCR repertoire.
Academic Article Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.
Academic Article Pre-TCR-induced beta-catenin facilitates traversal through beta-selection.
Academic Article Reply to Chien: Clarification of the effect of ligand on ?d-TCR repertoire selection.
Academic Article Ontogenic timing, T?cell receptor signal strength, and Notch signaling direct ?d T?cell functional differentiation in?vivo.
Academic Article Recent insights into the signals that control alphabeta/gammadelta-lineage fate.
Academic Article E proteins control the development of NK?dT cells through their invariant T cell receptor.
Academic Article TCF1 dosage determines cell fate during T cell development.
Academic Article Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
Academic Article TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck.
Academic Article Activation-induced ubiquitination of the T cell antigen receptor.
Academic Article Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR.
Academic Article The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.
Academic Article On the dynamics of TCR:CD3 complex cell surface expression and downmodulation.
Academic Article ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).
Academic Article Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.
Academic Article Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.
Academic Article Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
Academic Article Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.
Academic Article Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection.
Academic Article Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
Academic Article The expression of membrane and secreted immunoglobulin during the in vitro differentiation of the murine B cell lymphoma CH12.
Academic Article Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro.
Academic Article Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.
Academic Article Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement.
Academic Article Identification of a novel pre-TCR isoform in which the accessibility of the TCR beta subunit is determined by occupancy of the 'missing' V domain of pre-T alpha.
Academic Article Transmembrane polar residues of TCR beta chain are required for signal transduction.
Academic Article A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly.
Academic Article A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.
Academic Article Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.
Academic Article Branching out to gain control: how the pre-TCR is linked to multiple functions.
Academic Article Regulation of lineage commitment distinct from positive selection.
Academic Article Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.
Academic Article The connecting peptide domain of pT alpha dictates weak association of the pre-T cell receptor with the TCR zeta subunit.
Academic Article Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?
Academic Article Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.
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  • Histocompatibility Antigens Class II