Item Type | Name |
Concept
|
Adenocarcinoma
|
Concept
|
Cyclic AMP
|
Concept
|
Alcian Blue
|
Concept
|
Alcohol Dehydrogenase
|
Concept
|
Amino Acid Sequence
|
Concept
|
Anthraquinones
|
Concept
|
Antibodies
|
Concept
|
Asthma
|
Concept
|
Autophagy
|
Concept
|
Base Sequence
|
Concept
|
Body Weight
|
Concept
|
Bone Development
|
Concept
|
Bromates
|
Concept
|
Butylhydroxybutylnitrosamine
|
Concept
|
Capillaries
|
Concept
|
Carcinoma, Squamous Cell
|
Concept
|
Carcinoma, Transitional Cell
|
Concept
|
Cartilage, Articular
|
Concept
|
Cell Division
|
Concept
|
Chemotaxis
|
Concept
|
Chemotaxis, Leukocyte
|
Concept
|
Chromatography, Gel
|
Concept
|
Cicatrix
|
Concept
|
Cross-Linking Reagents
|
Concept
|
Culture Media
|
Concept
|
Cytoskeleton
|
Concept
|
Decidua
|
Concept
|
Diabetes Mellitus, Experimental
|
Concept
|
Diabetes Mellitus, Type 1
|
Concept
|
Diabetic Nephropathies
|
Concept
|
Dipeptides
|
Concept
|
Disulfides
|
Concept
|
Drug Synergism
|
Concept
|
Dystocia
|
Concept
|
Ehlers-Danlos Syndrome
|
Concept
|
Elastin
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
Concept
|
Endocytosis
|
Concept
|
Endometrium
|
Concept
|
Endoplasmic Reticulum
|
Concept
|
Endothelium, Corneal
|
Concept
|
Endothelium, Vascular
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
Concept
|
Epidermal Growth Factor
|
Concept
|
Epithelial Cells
|
Concept
|
Estrogens
|
Concept
|
Eye Burns
|
Concept
|
Fetal Membranes, Premature Rupture
|
Concept
|
Fibroblast Growth Factors
|
Concept
|
Fibronectins
|
Concept
|
Fluorescent Antibody Technique
|
Concept
|
Foreign-Body Reaction
|
Concept
|
Glomerular Mesangium
|
Concept
|
Glucuronidase
|
Concept
|
Glutaral
|
Concept
|
Glycoproteins
|
Concept
|
Growth Inhibitors
|
Concept
|
HeLa Cells
|
Concept
|
Heparin
|
Concept
|
Heparitin Sulfate
|
Concept
|
Homeostasis
|
Concept
|
Humans
|
Concept
|
Hypochlorous Acid
|
Concept
|
Immunity, Innate
|
Concept
|
Immunoenzyme Techniques
|
Concept
|
Immunohistochemistry
|
Concept
|
Incisor
|
Concept
|
Indicators and Reagents
|
Concept
|
Insulin
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Insulin-Like Growth Factor II
|
Concept
|
Intestinal Mucosa
|
Concept
|
Intestinal Neoplasms
|
Concept
|
Kidney Diseases
|
Concept
|
Kidney Glomerulus
|
Concept
|
Kidney Tubules
|
Concept
|
Leucine
|
Concept
|
Ligands
|
Concept
|
Lipase
|
Concept
|
Litter Size
|
Concept
|
Lung
|
Concept
|
Lung Compliance
|
Concept
|
Lung Volume Measurements
|
Concept
|
Lyme Disease
|
Concept
|
Lymphokines
|
Concept
|
Lysosomes
|
Concept
|
Mammary Neoplasms, Experimental
|
Concept
|
Metalloendopeptidases
|
Concept
|
Mice, Inbred BALB C
|
Concept
|
Mice, Inbred C3H
|
Concept
|
Mice, Inbred C57BL
|
Concept
|
Mice, Inbred Strains
|
Concept
|
Microscopy, Electron
|
Concept
|
Microscopy, Electron, Scanning
|
Concept
|
Microscopy, Fluorescence
|
Concept
|
Mitochondria
|
Concept
|
Molecular Sequence Data
|
Concept
|
Neoplasms, Experimental
|
Concept
|
Neutrophils
|
Concept
|
Terminology as Topic
|
Concept
|
Organ Culture Techniques
|
Concept
|
Organ Size
|
Concept
|
Osteogenesis
|
Concept
|
Oxytocin
|
Concept
|
Pepsin A
|
Concept
|
Physical Conditioning, Animal
|
Concept
|
Polyvinyl Alcohol
|
Concept
|
Positive-Pressure Respiration
|
Concept
|
Precipitin Tests
|
Concept
|
Progesterone
|
Concept
|
Prostatic Neoplasms
|
Concept
|
Radioisotopes
|
Concept
|
Random Allocation
|
Concept
|
Rats, Inbred SHR
|
Concept
|
Receptors, Androgen
|
Concept
|
Receptors, Cell Surface
|
Concept
|
Receptor, Epidermal Growth Factor
|
Concept
|
Receptor, Insulin
|
Concept
|
Receptors, Purinergic
|
Concept
|
RNA
|
Concept
|
RNA, Messenger
|
Concept
|
Sensitivity and Specificity
|
Concept
|
Severity of Illness Index
|
Concept
|
Sodium Hydroxide
|
Concept
|
Somatomedins
|
Concept
|
Streptozocin
|
Concept
|
Tumor Stem Cell Assay
|
Concept
|
Uterine Contraction
|
Concept
|
Zebrafish
|
Concept
|
Immunoblotting
|
Concept
|
Blotting, Northern
|
Concept
|
Blotting, Western
|
Concept
|
Colorectal Neoplasms
|
Concept
|
Protein Engineering
|
Concept
|
Reproducibility of Results
|
Concept
|
Genetic Therapy
|
Concept
|
Molecular Structure
|
Concept
|
Bone Density
|
Concept
|
Keratinocytes
|
Concept
|
Interleukin-6
|
Concept
|
Integrins
|
Concept
|
Genes, Tumor Suppressor
|
Concept
|
Cytokines
|
Concept
|
Transforming Growth Factor beta
|
Concept
|
Fibroblast Growth Factor 1
|
Concept
|
Fibroblast Growth Factor 2
|
Concept
|
Endothelial Growth Factors
|
Concept
|
Mutagenesis, Site-Directed
|
Concept
|
Oligonucleotides, Antisense
|
Concept
|
Interleukin-10
|
Concept
|
Culture Media, Conditioned
|
Concept
|
In Situ Hybridization
|
Concept
|
Receptors, Fibroblast Growth Factor
|
Concept
|
Receptor, IGF Type 1
|
Concept
|
Macrophages, Peritoneal
|
Concept
|
Patellar Ligament
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
Concept
|
Genes, Reporter
|
Concept
|
DNA Primers
|
Concept
|
Receptors, Growth Factor
|
Concept
|
DNA, Complementary
|
Concept
|
Mice, Knockout
|
Concept
|
Microscopy, Atomic Force
|
Concept
|
Receptor, ErbB-2
|
Concept
|
Intercellular Adhesion Molecule-1
|
Concept
|
Sepsis
|
Concept
|
Carcinoma, Lewis Lung
|
Concept
|
Antibodies, Blocking
|
Concept
|
Bone Morphogenetic Proteins
|
Concept
|
Tissue Inhibitor of Metalloproteinase-1
|
Concept
|
Guanidine
|
Concept
|
Heparan Sulfate Proteoglycans
|
Concept
|
Proto-Oncogene Proteins c-met
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
Concept
|
Caspases
|
Concept
|
Surface Plasmon Resonance
|
Concept
|
Angiogenesis Inhibitors
|
Concept
|
rhoA GTP-Binding Protein
|
Concept
|
Matrix Metalloproteinases
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
Concept
|
Enterocytes
|
Concept
|
Mitogen-Activated Protein Kinases
|
Concept
|
MAP Kinase Signaling System
|
Concept
|
Tissue Engineering
|
Concept
|
Collagen Type V
|
Concept
|
Collagen Type IV
|
Concept
|
Borrelia burgdorferi
|
Concept
|
Feedback, Physiological
|
Concept
|
RNA, Small Interfering
|
Concept
|
MicroRNAs
|
Concept
|
Receptor, EphA2
|
Concept
|
Parturition
|
Concept
|
Calreticulin
|
Concept
|
Organogenesis
|
Concept
|
Integrin alpha2beta1
|
Concept
|
Integrin alpha1beta1
|
Concept
|
Integrin alpha1
|
Concept
|
Vascular Endothelial Growth Factor Receptor-1
|
Concept
|
Vascular Endothelial Growth Factor Receptor-2
|
Concept
|
Vascular Endothelial Growth Factors
|
Concept
|
Vascular Endothelial Growth Factor A
|
Concept
|
Endothelial Cells
|
Concept
|
Angiostatic Proteins
|
Concept
|
Endostatins
|
Concept
|
Collagen Type XVIII
|
Concept
|
Culture Techniques
|
Concept
|
Microscopy, Electron, Transmission
|
Concept
|
beta-Cyclodextrins
|
Concept
|
Premature Birth
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
Concept
|
Mitogen-Activated Protein Kinase 3
|
Concept
|
Cell Growth Processes
|
Concept
|
Cell Proliferation
|
Concept
|
Proto-Oncogene Proteins c-cbl
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
Concept
|
Apoptosis Regulatory Proteins
|
Concept
|
Proto-Oncogene Proteins c-akt
|
Concept
|
Toll-Like Receptors
|
Concept
|
Toll-Like Receptor 2
|
Concept
|
Toll-Like Receptor 4
|
Concept
|
Caveolin 1
|
Concept
|
Focal Adhesion Protein-Tyrosine Kinases
|
Concept
|
Focal Adhesion Kinase 1
|
Concept
|
Paxillin
|
Concept
|
Receptor, Fibroblast Growth Factor, Type 1
|
Concept
|
Receptor, Fibroblast Growth Factor, Type 2
|
Concept
|
Fibroblast Growth Factor 7
|
Concept
|
Caspase 3
|
Concept
|
Caspase 8
|
Concept
|
Matrix Metalloproteinases, Secreted
|
Concept
|
Leukemia Inhibitory Factor
|
Concept
|
Aggrecans
|
Concept
|
Versicans
|
Concept
|
Transforming Growth Factor beta1
|
Concept
|
Transforming Growth Factor beta2
|
Concept
|
Protein Tyrosine Phosphatase, Non-Receptor Type 6
|
Concept
|
Tolloid-Like Metalloproteinases
|
Concept
|
Bone Morphogenetic Protein 1
|
Concept
|
Insulin Receptor Substrate Proteins
|
Concept
|
Cathepsin L
|
Concept
|
HEK293 Cells
|
Concept
|
TOR Serine-Threonine Kinases
|
Concept
|
Human Umbilical Vein Endothelial Cells
|
Academic Article
|
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.
|
Academic Article
|
Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.
|
Academic Article
|
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans.
|
Academic Article
|
Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice.
|
Academic Article
|
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
|
Academic Article
|
Endorepellin, the angiostatic module of perlecan, interacts with both the a2ß1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
|
Academic Article
|
Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.
|
Academic Article
|
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
|
Academic Article
|
Thrombospondins in physiology and disease: new tricks for old dogs.
|
Academic Article
|
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A.
|
Academic Article
|
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation.
|
Academic Article
|
The biology of small leucine-rich proteoglycans in bone pathophysiology.
|
Academic Article
|
Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways: TRANSCRIPTIONAL REPRESSION OF HYPOXIA-INDUCIBLE FACTOR 1a AND VEGFA AND CONCURRENT INHIBITION OF NUCLEAR FACTOR OF ACTIVATED T CELL 1 (NFAT1) ACTIVATION.
|
Academic Article
|
Biological interplay between proteoglycans and their innate immune receptors in inflammation.
|
Academic Article
|
Dichotomy of decorin activity on the insulin-like growth factor-I system.
|
Academic Article
|
Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells.
|
Academic Article
|
Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis.
|
Academic Article
|
Decorin suppresses tumor cell-mediated angiogenesis.
|
Academic Article
|
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope.
|
Academic Article
|
Androgen receptor expression induces FGF2, FGF-binding protein production, and FGF2 release in prostate carcinoma cells: role of FGF2 in growth, survival, and androgen receptor down-modulation.
|
Academic Article
|
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan.
|
Academic Article
|
In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer.
|
Academic Article
|
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.
|
Academic Article
|
The role of decorin in collagen fibrillogenesis and skin homeostasis.
|
Academic Article
|
Biologically active decorin is a monomer in solution.
|
Academic Article
|
Decorin deficiency leads to impaired angiogenesis in injured mouse cornea.
|
Academic Article
|
Decorin prevents metastatic spreading of breast cancer.
|
Academic Article
|
Decorin, a novel player in the insulin-like growth factor system.
|
Academic Article
|
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
|
Academic Article
|
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development.
|
Academic Article
|
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation.
|
Academic Article
|
Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation.
|
Academic Article
|
A role for decorin in cutaneous wound healing and angiogenesis.
|
Academic Article
|
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism.
|
Academic Article
|
Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice.
|
Academic Article
|
Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor.
|
Academic Article
|
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.
|
Academic Article
|
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis.
|
Academic Article
|
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices.
|
Academic Article
|
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity.
|
Academic Article
|
Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis.
|
Academic Article
|
Novel interactions of perlecan: unraveling perlecan's role in angiogenesis.
|
Academic Article
|
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation.
|
Academic Article
|
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
|
Academic Article
|
An antimetastatic role for decorin in breast cancer.
|
Academic Article
|
Diverse cell signaling events modulated by perlecan.
|
Academic Article
|
Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.
|
Academic Article
|
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
|
Academic Article
|
Decorin is a novel antagonistic ligand of the Met receptor.
|
Academic Article
|
Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.
|
Academic Article
|
A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.
|
Academic Article
|
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
|
Academic Article
|
The Tendon Injury Response is Influenced by Decorin and Biglycan.
|
Academic Article
|
Decorin Induces Mitophagy in Breast Carcinoma Cells via Peroxisome Proliferator-activated Receptor ? Coactivator-1a (PGC-1a) and Mitostatin.
|
Academic Article
|
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
|
Academic Article
|
Decorin differentially modulates the activity of insulin receptor isoform A ligands.
|
Academic Article
|
De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways.
|
Academic Article
|
Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
|
Academic Article
|
Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.
|
Academic Article
|
Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function.
|
Academic Article
|
The avß6 Integrin Is Transferred Intercellularly via Exosomes.
|
Academic Article
|
Cosmetics for the matrix: An attractive new style for Matrix Biology.
|
Academic Article
|
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.
|
Academic Article
|
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors.
|
Academic Article
|
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.
|
Academic Article
|
Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept.
|
Academic Article
|
Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1ß synthesis.
|
Academic Article
|
avß6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.
|
Academic Article
|
c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.
|
Grant
|
Natural EGFR Antagonists and Cancer
|
Grant
|
Altered Proteoglycan Gene Expression and Cancer
|
Grant
|
The Biology of Perlecan in Cancer and Angiogenesis
|
Academic Article
|
EphA2 is a functional receptor for the growth factor progranulin.
|
Academic Article
|
Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.
|
Academic Article
|
A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.
|
Academic Article
|
The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.
|
Academic Article
|
Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke.
|
Academic Article
|
Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.
|
Academic Article
|
Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin.
|
Academic Article
|
Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.
|
Academic Article
|
Extracellular matrix: the gatekeeper of tumor angiogenesis.
|
Concept
|
Beclin-1
|
Concept
|
Corneal Injuries
|
Grant
|
Proteoglycan regulation of tumor angiogenesis and endothelial cell autophagy
|
Academic Article
|
Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology.
|
Academic Article
|
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
|
Academic Article
|
Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer.
|
Academic Article
|
The functional role of decorin in corneal neovascularization in vivo.
|
Academic Article
|
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways.
|