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Lee, Kelvin
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full name Kelvin H Lee
label Lee, Kelvin
last name Lee
One or more keywords matched the following items that are connected to Lee, Kelvin
Item TypeName
Concept Adult
Concept Aged
Concept Aged, 80 and over
Concept Algorithms
Concept Amino Acid Sequence
Concept Animals
Concept Bacteria
Concept Base Sequence
Concept Cattle
Concept Cell Adhesion
Concept Cell Differentiation
Concept Cell Line, Transformed
Concept Cell Survival
Concept Cells, Cultured
Concept Chromatography, Liquid
Concept Computer Simulation
Concept Cricetulus
Concept Drosophila melanogaster
Concept Herpesvirus 4, Human
Concept Escherichia coli
Concept Feedback
Concept Poaceae
Concept Cricetinae
Concept Humans
Concept Image Processing, Computer-Assisted
Concept Longitudinal Studies
Concept Mammals
Concept Mentors
Concept Mice, Transgenic
Concept Middle Aged
Concept Molecular Sequence Data
Concept Research Design
Concept Software
Concept Staining and Labeling
Concept Stem Cells
Concept Students
Concept Teaching
Concept Vocabulary
Concept Human T-lymphotropic virus 1
Concept HIV-1
Concept CHO Cells
Concept Cell Death
Concept Rats, Wistar
Concept Arabidopsis
Concept Systems Integration
Concept Plant Roots
Concept Cell Culture Techniques
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Computational Biology
Concept Databases, Genetic
Concept Databases, Nucleic Acid
Concept Databases, Protein
Concept Endothelial Cells
Concept Thermotoga neapolitana
Concept Cell Proliferation
Concept Mice
Concept Rats
Concept Limit of Detection
Concept HEK293 Cells
Academic Article The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed -1 ribosomal frameshifting.
Academic Article Murine in vitro model of the blood-brain barrier for evaluating drug transport.
Academic Article Recent cerebrospinal fluid biomarker studies of Alzheimer's disease.
Academic Article Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology.
Academic Article Proteomic assessment of a cell model of spinal muscular atrophy.
Academic Article Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A.
Academic Article The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.
Academic Article RNA interference of cofilin in Chinese hamster ovary cells improves recombinant protein productivity.
Academic Article Proteomic and physiological experiments to test Thermotoga neapolitana constraint-based model hypotheses of carbon source utilization.
Academic Article Genomics in mammalian cell culture bioprocessing.
Academic Article Optimization of endothelial cell growth in a murine in vitro blood-brain barrier model.
Academic Article Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org.
Academic Article Profiling conserved microRNA expression in recombinant CHO cell lines using Illumina sequencing.
Academic Article A single nucleotide polymorphism in ycdC alters tRNA synthetase expression and results in hypersecretion in Escherichia coli.
Academic Article Optimization of protein sample preparation for two-dimensional electrophoresis.
Academic Article Longitudinal analysis of novel Alzheimer's disease proteomic cerebrospinal fluid biomarkers during intravenous immunoglobulin therapy.
Academic Article Serine Phosphorylation Is Critical for the Activation of Ubiquitin-Specific Protease 1 and Its Interaction with WD40-Repeat Protein UAF1.
Academic Article Membrane configuration optimization for a murine in vitro blood-brain barrier model.
Academic Article Workflow for quantitative proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags.
Academic Article Targeted human cerebrospinal fluid proteomics for the validation of multiple Alzheimer's disease biomarker candidates.
Academic Article Jay Bailey as mentor--the students' perspective.
Academic Article Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease.
Academic Article Studies of potential cerebrospinal fluid molecular markers for Alzheimer's disease.
Academic Article Quantitative and qualitative measure of intralaboratory two-dimensional protein gel reproducibility and the effects of sample preparation, sample load, and image analysis.
Academic Article Comparison of automated in-gel digest methods for femtomole level samples.
Academic Article Escherichia coli--a model system that benefits from and contributes to the evolution of proteomics.
Academic Article Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations.
Academic Article Insights into the relation between mrna and protein expression patterns: II. Experimental observations in Escherichia coli.
Academic Article Functional genomics and proteomics as a foundation for systems biology.
Academic Article A two-dimensional electrophoresis map of Chinese hamster ovary cell proteins based on fluorescence staining.
Academic Article Towards two-dimensional electrophoresis mapping of the cerebrospinal fluid proteome from a single individual.
Academic Article Engineering HlyA hypersecretion in Escherichia coli based on proteomic and microarray analyses.
Academic Article Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells.
Academic Article Isoelectric focusing in cyclic olefin copolymer microfluidic channels coated by polyacrylamide using a UV photografting method.
Academic Article Quantitative analysis of protein expression using amine-specific isobaric tags in Escherichia coli cells expressing rhsA elements.
Academic Article Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease.
Academic Article A comparison of the consistency of proteome quantitation using two-dimensional electrophoresis and shotgun isobaric tagging in Escherichia coli cells.
Academic Article Coupling on-chip solid-phase extraction to electrospray mass spectrometry through an integrated electrospray tip.
Academic Article Improved understanding of gene expression regulation using systems biology.
Academic Article Alzheimer's disease cerebrospinal fluid biomarker discovery: a proteomics approach.
Academic Article Shotgun proteomics using the iTRAQ isobaric tags.
Academic Article Two-dimensional protein electrophoresis: from molecular pathway discovery to biomarker discovery in neurological disorders.
Academic Article Proteomic analysis of cerebrospinal fluid changes related to postmortem interval.
Academic Article Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1.
Academic Article Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease.
Academic Article Genomics and proteomics in process development: opportunities and challenges.
Academic Article PERIOD-TIMELESS interval timer may require an additional feedback loop.
Academic Article 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease.
Academic Article iTRAQPak: an R based analysis and visualization package for 8-plex isobaric protein expression data.
Academic Article Silent mutations result in HlyA hypersecretion by reducing intracellular HlyA protein aggregates.
Academic Article Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue.
Academic Article FSscan: a mechanism-based program to identify +1 ribosomal frameshift hotspots.
Academic Article Phragmites australis root secreted phytotoxin undergoes photo-degradation to execute severe phytotoxicity.
Academic Article Synthesis and characterization of high-throughput nanofabricated poly(4-hydroxy styrene) membranes for in vitro models of barrier tissue.
Academic Article The effect of astrocytes on the induction of barrier properties in aortic endothelial cells.
Academic Article Recovery of Chinese hamster ovary host cell proteins for proteomic analysis.
Academic Article Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing.
Academic Article Effects of copper on CHO cells: Insights from gene expression analyses.
Academic Article miRNA Expression in CHO: Nature knows best.
Academic Article Amyloid-ß concentration and structure influences the transport and immunomodulatory effects of IVIG.
Academic Article Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome.
Academic Article Toward product attribute control: developments from genome sequencing.
Academic Article Editorial overview: Nanobiotechnology.
Academic Article Sequencing technologies for animal cell culture research.
Academic Article Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.
Academic Article Applications of affinity chromatography in proteomics.
Academic Article CHOgenome.org 2.0: Genome resources and website updates.
Academic Article Improved protease digestion conditions for membrane protein detection.
Academic Article Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum.
Academic Article Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease.
Academic Article Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification.
Academic Article Toward improved host cell protein impurity assessment.
Academic Article Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels.
Academic Article Chlorobaculum tepidum Modulates Amino Acid Composition in Response to Energy Availability, as Revealed by a Systematic Exploration of the Energy Landscape of Phototrophic Sulfur Oxidation.
Academic Article CHO Cells Can Make More Protein.
Academic Article A framework to quantify karyotype variation associated with CHO production instability.
Academic Article Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood-Brain Barrier Model.
Grant Proteome Markers for Alzheimer's Disease Diagnosis
Academic Article Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations.
Academic Article Growth Rate Changes in CHO Host Cells Are Associated with Karyotypic Heterogeneity.
Academic Article Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices.
Academic Article Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels.
Academic Article Glyco-Mapper: A Chinese hamster ovary (CHO) genome-specific glycosylation prediction tool.
Academic Article Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.
Academic Article A reference genome of the Chinese hamster based on a hybrid assembly strategy.
Academic Article Mechanisms of precipitate formation during the purification of an Fc-fusion protein.
Academic Article A differentiating neural stem cell-derived astrocytic population mitigates the inflammatory effects of TNF-a and IL-6 in an iPSC-based blood-brain barrier model.
Academic Article Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood-Brain Barrier Model.
Academic Article The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem.
Academic Article Bioinformatic analysis of Chinese hamster ovary host cell protein lipases.
Academic Article IgG transport increases in an in vitro blood-brain barrier model with Amyloid-ß and with neuroinflammatory cytokines.
Academic Article Site-specific Integration Ushers in a New Era of Precise CHO Cell Line Engineering.
Academic Article Cyberbiosecurity for Biopharmaceutical Products.
Concept Machine Learning
Academic Article NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.
Academic Article Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn.
Academic Article A Site-Specific Integration Reporter System That Enables Rapid Evaluation of CRISPR/Cas9-Mediated Genome Editing Strategies in CHO Cells.
Academic Article Chromosome-scale scaffolds for the Chinese hamster reference genome assembly to facilitate the study of the CHO epigenome.
Academic Article NIIMBL-facilitated Active Listening Meeting between industry and FDA identifies common challenges for adoption of new biopharmaceutical manufacturing technologies.
Academic Article Summary from Advanced Manufacturing Technology Workshop held at 6th Accelerating Biopharmaceutical Development Meeting.
Academic Article Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach.
Academic Article Adsorptive-Mediated Endocytosis of Sulfo-Cy5-Labeled IgG Causes Aberrant IgG Processing by Brain Endothelial-Like Cells.
Academic Article Systematic identification of safe harbor regions in the CHO genome through a comprehensive epigenome analysis.
Academic Article DNA Double-Strand Breaks Affect Chromosomal Rearrangements during Methotrexate-Mediated Gene Amplification in Chinese Hamster Ovary Cells.
Academic Article k-mer-Based Metagenomics Tools Provide a Fast and Sensitive Approach for the Detection of Viral Contaminants in Biopharmaceutical and Vaccine Manufacturing Applications Using Next-Generation Sequencing.
Academic Article Analytical methods to characterize recombinant adeno-associated virus vectors and the benefit of standardization and reference materials.
Academic Article Rapid Development and Validation of a Novel Laboratory-Derived Test for the Detection of SARS-CoV-2.
Academic Article Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.
Academic Article Creation of monoclonal antibody expressing CHO cell lines grown with sodium butyrate and characterization of resulting antibody glycosylation.
Academic Article Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells.
Academic Article Method to transfer Chinese hamster ovary (CHO) batch shake flask experiments to large-scale, computer-controlled fed-batch bioreactors.
Academic Article EvalDNA: a machine learning-based tool for the comprehensive evaluation of mammalian genome assembly quality.
Academic Article Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions.
Academic Article Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines.
Academic Article Bioindustrial manufacturing readiness levels (BioMRLs) as a shared framework for measuring and communicating the maturity of bioproduct manufacturing processes.
Academic Article Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.
Academic Article Biomanufacturing readiness levels [BRL]-A shared vocabulary for biopharmaceutical technology development and commercialization.
Academic Article Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing.
Academic Article Comparison of vector elements and process conditions in transient and stable suspension HEK293 platforms using SARS-CoV-2 receptor binding domain as a model protein.
Academic Article High-efficiency and multilocus targeted integration in CHO cells using CRISPR-mediated donor nicking and DNA repair inhibitors.
Academic Article Analytical characterization of host-cell-protein-rich aggregates in monoclonal antibody solutions.
Academic Article Driving adoption of new technologies in biopharmaceutical manufacturing.
Academic Article A compendium of stable hotspots in the CHO genome.
Academic Article Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography.
Academic Article Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing.
Academic Article Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.
Academic Article NIIMBL's viral vector program: A cross-gene therapy community collaboration to transform viral vector development and manufacturing.
Academic Article Prediction of CHO cell line stability using expression of DNA repair genes.
Academic Article Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.
Academic Article A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system.
Academic Article Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development.
Academic Article Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese Hamster Ovary (CHO) cell metabolism and N-linked glycosylation in the Fab and Fc regions of the produced IgG.
Academic Article A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells.
Academic Article Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography.
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