Thomas Jefferson University

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Aplin, Andrew
One or more keywords matched the following items that are connected to Aplin, Andrew
Item TypeName
Concept Melanoma
Concept Melanoma, Experimental
Concept Melanoma-Specific Antigens
Academic Article alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.
Academic Article FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells.
Academic Article The wrath of RAFs: rogue behavior of B-RAF kinase inhibitors.
Academic Article Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.
Academic Article CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway.
Academic Article Paying "particle" attention to novel melanoma treatment strategies.
Academic Article Mind the BAP.
Academic Article FOXD3 regulates migration properties and Rnd3 expression in melanoma cells.
Academic Article Mechanisms of resistance to RAF inhibitors in melanoma.
Academic Article Finding the root of the problem: the quest to identify melanoma stem cells.
Academic Article Axl of evil?
Academic Article Meeting report from the 2011 International Melanoma Congress, Tampa, Florida.
Academic Article The Yin-Yang of RAF inhibitors.
Academic Article TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells.
Academic Article Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells.
Academic Article Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells.
Academic Article Meeting report: The future of preclinical mouse models in melanoma treatment is now.
Academic Article Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.
Academic Article A STATement on Vemurafenib-Resistant Melanoma.
Academic Article Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells.
Academic Article Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling.
Academic Article Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progression.
Academic Article Melanocyte receptors: clinical implications and therapeutic relevance.
Academic Article B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization.
Academic Article Skp2 regulates G2/M progression in a p53-dependent manner.
Academic Article Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
Academic Article Mcl-1 is required for melanoma cell resistance to anoikis.
Academic Article Hippo: hungry, hungry for melanoma invasion.
Academic Article Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.
Academic Article Beneficial Effects of RAF Inhibitor in Mutant BRAF Splice Variant-Expressing Melanoma.
Academic Article FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma.
Academic Article Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma.
Academic Article Adaptive resistance to RAF inhibitors in melanoma.
Academic Article Unmet needs in melanoma research.
Academic Article Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells.
Academic Article What shall we do this year?
Academic Article Game of isoforms: PI3K ß-sparing inhibitor is coming.
Academic Article The value of thesis advisers.
Academic Article Animal experimentation - questioned again!
Academic Article NF-?B Regulation of c-FLIP Promotes TNFa-Mediated RAF Inhibitor Resistance in Melanoma.
Academic Article The value of thesis advisers.
Academic Article Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma.
Academic Article RAC1 P29S regulates PD-L1 expression in melanoma.
Academic Article ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas.
Academic Article PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma.
Academic Article Fibroblast-derived Neuregulin 1 Promotes Compensatory ErbB3 Receptor Signaling in Mutant BRAF Melanoma.
Academic Article Welcome to the New Year!
Academic Article Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization.
Academic Article MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.
Academic Article Of Mice and Melanoma: PDX System for Modeling Personalized Medicine.
Academic Article Targeting mutant NRAS signaling pathways in melanoma.
Academic Article The state of melanoma: challenges and opportunities.
Academic Article The melanoma field with dendritic roots.
Academic Article An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma.
Academic Article Triple jeopardy for people with albinism.
Grant Targeted therapies in cutaneous melanoma
Grant ADHESION AND ERK SIGNALING IN MELANOMA
Grant Mutant BRAF-regulated transcription factors in melanoma progression
Grant FOXD3 up-regulation and ERBB3 signaling as an adaptive response to BRAF inhibitors in melanoma
Grant B-RAF Regulation of the Cell Cycle in Melanoma
Academic Article Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma.
Academic Article Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis.
Academic Article Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.
Academic Article Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho.
Academic Article The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells.
Academic Article A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.
Academic Article Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo.
Academic Article A pre-existing rare PIK3CAE545K subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling.
Academic Article ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
Academic Article "If you want to go far, go together".
Academic Article Novel therapeutic strategies and targets in advanced uveal melanoma.
Academic Article Running INTERFERONce on immunotherapy.
Academic Article Publisher Correction: ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
Academic Article Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article Playing the melanoma endgame.
Academic Article ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma.
Academic Article Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma.
Academic Article Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma.
Academic Article BET inhibition modifies melanoma infiltrating T cells and enhances response to PD-L1 blockade.
Academic Article Inhibition of NF-?B-dependent signaling enhances sensitivity and overcomes resistance to BET inhibition in uveal melanoma.
Academic Article Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Academic Article The next generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
Academic Article Murine cytomegalovirus infection of melanoma lesions delays tumor growth by recruiting and re-polarizing monocytic phagocytes in the tumor.
Academic Article m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo.
Academic Article In vivo ERK1/2 reporter predictively models response and resistance to combined BRAF and MEK inhibitors in melanoma.
Academic Article PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves BET inhibitor efficacy in melanoma.
Academic Article Decitabine limits escape from MEK inhibition in uveal melanoma.
Academic Article FOXD3 Regulates VISTA Expression in Melanoma.
Academic Article Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma.
Academic Article Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma.
Academic Article Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma.
Academic Article Targeting PHGDH upregulation reduces glutathione levels and re-sensitizes resistant NRAS mutant melanoma to MEK inhibition.
Academic Article The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019).
Academic Article Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
Academic Article BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
Grant Mechanisms of uveal melanoma dormancy and targeted therapy tolerance
Grant Targeting Systems Vulnerabilities in the G?q/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
Academic Article Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Academic Article Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma.
Academic Article Melanoma models for the next generation of therapies.
Academic Article Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
Grant Mechanisms of cell death in cutaneous melanoma
Academic Article Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.
Academic Article Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Academic Article The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.
Academic Article Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma.
Academic Article SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects.
Academic Article Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.
Academic Article Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma.
Academic Article The future of targeted kinase inhibitors in melanoma.
Academic Article Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.
Academic Article A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma.
Search Criteria
  • Melanoma