Item Type | Name |
Concept
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Melanoma
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Concept
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Melanoma, Experimental
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Concept
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Melanoma-Specific Antigens
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Academic Article
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alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.
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Academic Article
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FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells.
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Academic Article
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The wrath of RAFs: rogue behavior of B-RAF kinase inhibitors.
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Academic Article
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Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.
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Academic Article
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CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway.
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Academic Article
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Paying "particle" attention to novel melanoma treatment strategies.
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Academic Article
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Mind the BAP.
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Academic Article
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FOXD3 regulates migration properties and Rnd3 expression in melanoma cells.
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Academic Article
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Mechanisms of resistance to RAF inhibitors in melanoma.
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Academic Article
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Finding the root of the problem: the quest to identify melanoma stem cells.
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Academic Article
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Axl of evil?
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Academic Article
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Meeting report from the 2011 International Melanoma Congress, Tampa, Florida.
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Academic Article
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The Yin-Yang of RAF inhibitors.
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Academic Article
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TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells.
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Academic Article
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Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells.
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Academic Article
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Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells.
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Academic Article
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Meeting report: The future of preclinical mouse models in melanoma treatment is now.
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Academic Article
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Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.
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Academic Article
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A STATement on Vemurafenib-Resistant Melanoma.
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Academic Article
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Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells.
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Academic Article
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Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling.
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Academic Article
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Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progression.
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Academic Article
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Melanocyte receptors: clinical implications and therapeutic relevance.
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Academic Article
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B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization.
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Academic Article
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Skp2 regulates G2/M progression in a p53-dependent manner.
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Academic Article
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Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
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Academic Article
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Mcl-1 is required for melanoma cell resistance to anoikis.
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Academic Article
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Hippo: hungry, hungry for melanoma invasion.
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Academic Article
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Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.
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Academic Article
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Beneficial Effects of RAF Inhibitor in Mutant BRAF Splice Variant-Expressing Melanoma.
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Academic Article
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FOXD3 Modulates Migration through Direct Transcriptional Repression of TWIST1 in Melanoma.
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Academic Article
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Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma.
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Academic Article
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Adaptive resistance to RAF inhibitors in melanoma.
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Academic Article
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Unmet needs in melanoma research.
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Academic Article
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Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells.
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Academic Article
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What shall we do this year?
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Academic Article
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Game of isoforms: PI3K ß-sparing inhibitor is coming.
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Academic Article
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The value of thesis advisers.
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Academic Article
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Animal experimentation - questioned again!
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Academic Article
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NF-?B Regulation of c-FLIP Promotes TNFa-Mediated RAF Inhibitor Resistance in Melanoma.
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Academic Article
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The value of thesis advisers.
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Academic Article
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Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma.
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Academic Article
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RAC1 P29S regulates PD-L1 expression in melanoma.
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Academic Article
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ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas.
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Academic Article
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PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma.
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Academic Article
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Fibroblast-derived Neuregulin 1 Promotes Compensatory ErbB3 Receptor Signaling in Mutant BRAF Melanoma.
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Academic Article
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Welcome to the New Year!
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Academic Article
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Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization.
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Academic Article
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MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.
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Academic Article
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Of Mice and Melanoma: PDX System for Modeling Personalized Medicine.
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Academic Article
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Targeting mutant NRAS signaling pathways in melanoma.
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Academic Article
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The state of melanoma: challenges and opportunities.
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Academic Article
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The melanoma field with dendritic roots.
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Academic Article
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An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma.
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Academic Article
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Triple jeopardy for people with albinism.
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Grant
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Targeted therapies in cutaneous melanoma
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Grant
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ADHESION AND ERK SIGNALING IN MELANOMA
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Grant
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Mutant BRAF-regulated transcription factors in melanoma progression
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Grant
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FOXD3 up-regulation and ERBB3 signaling as an adaptive response to BRAF inhibitors in melanoma
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Grant
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B-RAF Regulation of the Cell Cycle in Melanoma
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Academic Article
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Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma.
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Academic Article
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Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis.
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Academic Article
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Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.
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Academic Article
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Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho.
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Academic Article
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The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells.
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Academic Article
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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.
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Academic Article
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Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo.
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Academic Article
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A pre-existing rare PIK3CAE545K subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling.
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Academic Article
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ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
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Academic Article
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"If you want to go far, go together".
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Academic Article
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Novel therapeutic strategies and targets in advanced uveal melanoma.
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Academic Article
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Running INTERFERONce on immunotherapy.
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Academic Article
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Publisher Correction: ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
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Academic Article
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Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
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Academic Article
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Playing the melanoma endgame.
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Academic Article
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ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma.
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Academic Article
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Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma.
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Academic Article
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Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma.
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Academic Article
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BET inhibition modifies melanoma infiltrating T cells and enhances response to PD-L1 blockade.
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Academic Article
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Inhibition of NF-?B-dependent signaling enhances sensitivity and overcomes resistance to BET inhibition in uveal melanoma.
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Academic Article
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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
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Academic Article
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The next generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
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Academic Article
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Murine cytomegalovirus infection of melanoma lesions delays tumor growth by recruiting and re-polarizing monocytic phagocytes in the tumor.
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Academic Article
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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
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Academic Article
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C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo.
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Academic Article
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In vivo ERK1/2 reporter predictively models response and resistance to combined BRAF and MEK inhibitors in melanoma.
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Academic Article
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PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves BET inhibitor efficacy in melanoma.
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Academic Article
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Decitabine limits escape from MEK inhibition in uveal melanoma.
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Academic Article
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FOXD3 Regulates VISTA Expression in Melanoma.
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Academic Article
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Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma.
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Academic Article
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Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma.
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Academic Article
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Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma.
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Academic Article
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Targeting PHGDH upregulation reduces glutathione levels and re-sensitizes resistant NRAS mutant melanoma to MEK inhibition.
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Academic Article
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The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019).
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Academic Article
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Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
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Academic Article
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BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
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Grant
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Mechanisms of uveal melanoma dormancy and targeted therapy tolerance
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Grant
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Targeting Systems Vulnerabilities in the G?q/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
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Academic Article
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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
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Academic Article
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Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma.
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Academic Article
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Melanoma models for the next generation of therapies.
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Academic Article
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Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
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Grant
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Mechanisms of cell death in cutaneous melanoma
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Academic Article
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Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.
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Academic Article
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Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
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Academic Article
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The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.
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Academic Article
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Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma.
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Academic Article
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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects.
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Academic Article
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Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.
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