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Colman, Roberta
One or more keywords matched the following items that are connected to Colman, Roberta
Item TypeName
Concept Kinetics
Academic Article Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function.
Academic Article Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts.
Academic Article In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes.
Academic Article A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis.
Academic Article Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required.
Academic Article A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase.
Academic Article Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase.
Academic Article Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase.
Academic Article Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism.
Academic Article Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role.
Academic Article The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies.
Academic Article Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.
Academic Article Monobromobimane occupies a distinct xenobiotic substrate site in glutathione S-transferase pi.
Academic Article Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis.
Academic Article Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium.
Academic Article Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis.
Academic Article Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL.
Academic Article Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase.
Academic Article Adenosine 2'-monophosphate, 5'-O-[S-(4-succinimidylbenzophenone)-thiophosphate]: a new photoaffinity label for the coenzyme site of porcine NADP-specific isocitrate dehydrogenase.
Academic Article Communication between the two active sites of glutathione S-transferase A1-1, probed using wild-type-mutant heterodimers.
Academic Article Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase.
Academic Article Delineation of xenobiotic substrate sites in rat glutathione S-transferase M1-1.
Academic Article Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes.
Academic Article Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1.
Academic Article Catalytically active monomer of class mu glutathione transferase from rat.
Academic Article Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase.
Academic Article Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.
Academic Article Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase.
Academic Article Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi.
Academic Article Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase.
Academic Article Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin.
Academic Article Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens.
Academic Article Catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits.
Academic Article Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants.
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