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One or more keywords matched the following items that are connected to Alnemri, Emad
Item TypeName
Concept Enzyme Activation
Academic Article Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells.
Academic Article Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.
Academic Article Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Academic Article IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
Academic Article Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance.
Academic Article Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Academic Article Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.
Academic Article Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Academic Article Calpain activation is upstream of caspases in radiation-induced apoptosis.
Academic Article Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae.
Academic Article Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
Academic Article Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
Academic Article Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Academic Article Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile.
Academic Article B cell apoptosis triggered by antigen receptor ligation proceeds via a novel caspase-dependent pathway.
Academic Article Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Academic Article Negative regulation of the Apaf-1 apoptosome by Hsp70.
Academic Article Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90.
Academic Article Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Academic Article Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
Academic Article Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
Academic Article A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Academic Article Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3.
Academic Article Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
Academic Article c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells.
Academic Article Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Academic Article The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.
Academic Article Mechanism of XIAP-mediated inhibition of caspase-9.
Academic Article Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
Academic Article Role of Smac in human leukaemic cell apoptosis and proliferation.
Academic Article Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
Academic Article The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
Academic Article The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
Academic Article Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Academic Article The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
Academic Article Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
Academic Article In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Academic Article AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Academic Article Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
Academic Article The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
Academic Article Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Academic Article Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.
Academic Article Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
Academic Article Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases.
Academic Article Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
Academic Article FLIP is expressed in mouse testis and protects germ cells from apoptosis.
Academic Article Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
Academic Article The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity.
Academic Article Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth.
Academic Article Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells.
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