Thomas Jefferson University

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Alnemri, Emad
One or more keywords matched the following items that are connected to Alnemri, Emad
Item TypeName
Concept Bacterial Proteins
Concept Calcium-Binding Proteins
Concept Carrier Proteins
Concept Cytoskeletal Proteins
Concept DNA-Binding Proteins
Concept Heat-Shock Proteins
Concept Luminescent Proteins
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Neoplasm Proteins
Concept Nuclear Proteins
Concept Plant Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Protein Kinase C
Concept Protein Kinases
Concept Protein Precursors
Concept Protein Processing, Post-Translational
Concept Protein Synthesis Inhibitors
Concept Protein-Tyrosine Kinases
Concept Proteins
Concept Proto-Oncogene Proteins
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Protein Biosynthesis
Concept Viral Proteins
Concept Helminth Proteins
Concept Tumor Suppressor Protein p53
Concept Protein-Serine-Threonine Kinases
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Adenovirus E1A Proteins
Concept HSP70 Heat-Shock Proteins
Concept HSP90 Heat-Shock Proteins
Concept GTP-Binding Proteins
Concept Proto-Oncogene Proteins c-bcl-2
Concept Insect Proteins
Concept Proto-Oncogene Proteins c-raf
Concept Protein Isoforms
Concept Protein Transport
Concept Tacrolimus Binding Proteins
Concept Mitochondrial Proteins
Concept Membrane Transport Proteins
Concept Arabidopsis Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Drosophila Proteins
Concept Caenorhabditis elegans Proteins
Concept Mitochondrial Membrane Transport Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Ubiquitin-Protein Ligases
Concept Protein Kinase Inhibitors
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Green Fluorescent Proteins
Concept bcl-2 Homologous Antagonist-Killer Protein
Concept Apoptosis Regulatory Proteins
Concept bcl-X Protein
Concept BH3 Interacting Domain Death Agonist Protein
Concept bcl-Associated Death Protein
Concept bcl-2-Associated X Protein
Concept Inhibitor of Apoptosis Proteins
Concept X-Linked Inhibitor of Apoptosis Protein
Concept Protein Kinase C-delta
Concept DNA-Activated Protein Kinase
Concept Pore Forming Cytotoxic Proteins
Concept Fas-Associated Death Domain Protein
Concept Fas Ligand Protein
Concept CRADD Signaling Adaptor Protein
Concept Receptor-Interacting Protein Serine-Threonine Kinases
Concept CASP8 and FADD-Like Apoptosis Regulating Protein
Concept CARD Signaling Adaptor Proteins
Concept Protein Multimerization
Concept GPI-Linked Proteins
Academic Article Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 identified in an atypical autoinflammatory disorder.
Academic Article Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells.
Academic Article The AIM2 inflammasome is critical for innate immunity to Francisella tularensis.
Academic Article Sensing cytoplasmic danger signals by the inflammasome.
Academic Article Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes.
Academic Article FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
Academic Article Overexpression and characterization of the human mineralocorticoid receptor.
Academic Article Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence.
Academic Article Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
Academic Article Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Academic Article The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.
Academic Article Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
Academic Article IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
Academic Article Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits.
Academic Article The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts.
Academic Article Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.
Academic Article Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance.
Academic Article Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Academic Article Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Academic Article Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.
Academic Article Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Academic Article E1A-induced processing of procaspase-8 can occur independently of FADD and is inhibited by Bcl-2.
Academic Article Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells.
Academic Article Calpain activation is upstream of caspases in radiation-induced apoptosis.
Academic Article Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
Academic Article Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis.
Academic Article Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
Academic Article Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.
Academic Article Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
Academic Article CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
Academic Article Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Academic Article Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.
Academic Article Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile.
Academic Article Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Academic Article Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome.
Academic Article Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells.
Academic Article Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II.
Academic Article Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor.
Academic Article TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis.
Academic Article Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
Academic Article Negative regulation of the Apaf-1 apoptosome by Hsp70.
Academic Article Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90.
Academic Article Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Academic Article Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
Academic Article CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
Academic Article vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
Academic Article Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
Academic Article A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Academic Article Structural basis of caspase-7 inhibition by XIAP.
Academic Article Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
Academic Article Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3.
Academic Article CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Academic Article Caspase cleavage enhances the apoptosis-inducing effects of BAD.
Academic Article Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
Academic Article FGF induces a switch in death receptor pathways in neuronal cells.
Academic Article Cell-free synthesis of rat glucocorticoid receptor in rabbit reticulocyte lysate. In vitro synthesis of receptor in Mr 90,000 heat shock protein-depleted lysate.
Academic Article c-IAP1 blocks TNFalpha-mediated cytotoxicity upstream of caspase-dependent and -independent mitochondrial events in human leukemic cells.
Academic Article Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
Academic Article Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Academic Article Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.
Academic Article Characterization and purification of a functional rat glucocorticoid receptor overexpressed in a baculovirus system.
Academic Article The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.
Academic Article sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
Academic Article Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.
Academic Article Mechanism of XIAP-mediated inhibition of caspase-9.
Academic Article Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
Academic Article Role of Smac in human leukaemic cell apoptosis and proliferation.
Academic Article Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Academic Article Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
Academic Article The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
Academic Article Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Academic Article Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Academic Article Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis.
Academic Article Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
Academic Article Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils.
Academic Article The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
Academic Article Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.
Academic Article Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.
Academic Article Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Academic Article Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Academic Article FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex.
Academic Article Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.
Academic Article CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
Academic Article The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.
Academic Article Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter.
Academic Article Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.
Academic Article Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.
Academic Article HtrA2 and Parkinson's disease: think PINK?
Academic Article Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein.
Academic Article The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors.
Academic Article Mutations in NALP12 cause hereditary periodic fever syndromes.
Academic Article The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.
Academic Article The NLR gene family: a standard nomenclature.
Academic Article Assembly, purification, and assay of the activity of the ASC pyroptosome.
Academic Article DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
Academic Article Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Academic Article X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Academic Article In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Academic Article AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Academic Article Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
Academic Article Human ICE/CED-3 protease nomenclature.
Academic Article Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Academic Article The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
Academic Article THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
Academic Article Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis.
Academic Article Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.
Academic Article Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35.
Academic Article Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases.
Academic Article Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
Academic Article CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
Academic Article Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide.
Academic Article Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
Academic Article Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.
Academic Article FLIP is expressed in mouse testis and protects germ cells from apoptosis.
Academic Article Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
Academic Article The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity.
Academic Article Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.
Academic Article Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells.
Academic Article An immunophilin is a component of the insect ecdysone receptor (EcR) complex.
Academic Article Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP.
Academic Article Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation.
Academic Article Gasdermins: novel mitochondrial pore-forming proteins.
Concept Protein Domains
Concept WNK Lysine-Deficient Protein Kinase 1
Concept NLR Family, Pyrin Domain-Containing 3 Protein
Academic Article Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
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  • GTP Binding Proteins