Thomas Jefferson University

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Benovic, Jeffrey
One or more keywords matched the following items that are connected to Benovic, Jeffrey
Item TypeName
Concept Adenosine Triphosphatases
Concept Haloperidol
Concept HeLa Cells
Concept Humans
Concept Hydroxyindoleacetic Acid
Concept Immunohistochemistry
Concept Insect Hormones
Concept Kidney
Concept Kinetics
Concept Protein Kinase C
Concept Protein Kinases
Concept Receptors, Histamine H1
Concept NF-kappa B
Concept Protein-Serine-Threonine Kinases
Concept Sequence Homology, Amino Acid
Concept In Situ Hybridization
Concept Cyclic AMP-Dependent Protein Kinases
Concept HSP90 Heat-Shock Proteins
Concept HL-60 Cells
Concept src-Family Kinases
Concept Mitogen-Activated Protein Kinase 1
Concept K562 Cells
Concept Guanine Nucleotide Exchange Factors
Concept I-kappa B Proteins
Concept Receptor Protein-Tyrosine Kinases
Concept EF Hand Motifs
Concept MAP Kinase Signaling System
Concept Heterotrimeric GTP-Binding Proteins
Concept Mammary Glands, Human
Concept Receptors, Serotonin, 5-HT2
Concept Receptors, Serotonin, 5-HT4
Concept Casein Kinase II
Concept Protein Kinase Inhibitors
Concept Extracellular Signal-Regulated MAP Kinases
Concept Mitogen-Activated Protein Kinase 3
Concept I-kappa B Kinase
Concept beta-Adrenergic Receptor Kinases
Concept NF-kappa B p50 Subunit
Concept G-Protein-Coupled Receptor Kinases
Concept G-Protein-Coupled Receptor Kinase 2
Concept G-Protein-Coupled Receptor Kinase 3
Concept G-Protein-Coupled Receptor Kinase 5
Concept Gene Knockdown Techniques
Concept Gene Knockout Techniques
Concept HEK293 Cells
Academic Article Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.
Academic Article Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.
Academic Article Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
Academic Article Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.
Academic Article Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but ß-arrestin-independent pathways.
Academic Article Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Academic Article Differential expression of arrestins is a predictor of breast cancer progression and survival.
Academic Article G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.
Academic Article Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.
Academic Article G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.
Academic Article Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.
Academic Article G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.
Academic Article Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic Acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.
Academic Article Identification of phosphorylation sites in the COOH-terminal tail of the µ-opioid receptor.
Academic Article ß-Arrestins and G Protein-Coupled Receptor Trafficking.
Academic Article G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation.
Academic Article Fluorescence microscopy techniques for the study of G protein-coupled receptor trafficking.
Academic Article Characterization of G protein-coupled receptor kinases.
Academic Article Characterization of arrestin expression and function.
Academic Article Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2.
Academic Article Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis.
Academic Article Regulation of arrestin-3 phosphorylation by casein kinase II.
Academic Article Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking.
Academic Article Biological actions of formoterol isomers.
Academic Article The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction.
Academic Article G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.
Academic Article Novel beta2-adrenergic receptor signaling pathways.
Academic Article The ins and outs of G protein-coupled receptor trafficking.
Academic Article Differential interaction of GRK2 with members of the G alpha q family.
Academic Article Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation.
Academic Article Mapping the arrestin-receptor interface. Structural elements responsible for receptor specificity of arrestin proteins.
Academic Article G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation.
Academic Article The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
Academic Article Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin.
Academic Article A predicted amphipathic helix mediates plasma membrane localization of GRK5.
Academic Article Characterization of the GRK2 binding site of Galphaq.
Academic Article Analysis of G-protein-coupled receptor kinase RGS homology domains.
Academic Article A new key in breast cancer metastasis.
Academic Article Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2.
Academic Article Arrestin2 expression selectively increases during neural differentiation.
Academic Article Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.
Academic Article Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2.
Academic Article P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.
Academic Article Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery.
Academic Article Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.
Academic Article Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding.
Academic Article The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.
Academic Article Distinct clathrin-coated pits sort different G protein-coupled receptor cargo.
Academic Article Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.
Academic Article Regulation of receptor trafficking by GRKs and arrestins.
Academic Article Regulation of CXCR4 signaling.
Academic Article Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.
Academic Article Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.
Academic Article Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment.
Academic Article Regulation of heterotrimeric G protein signaling in airway smooth muscle.
Academic Article Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation.
Academic Article M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms.
Academic Article beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation.
Academic Article Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori.
Academic Article Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer.
Academic Article Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2.
Academic Article Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
Academic Article Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking.
Academic Article Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.
Academic Article G-protein-coupled-receptor kinases mediate TNFa-induced NF?B signalling via direct interaction with and phosphorylation of I?Ba.
Academic Article ß-Arrestins and G Protein-Coupled Receptor Trafficking.
Academic Article Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Academic Article Call for Papers! A Special Thematic Compilation/Special Issue Crossover with ACS Chemical Biology, ACS Medicinal Chemistry Letters, and the Journal of Medicinal Chemistry Focused on New Frontiers in Kinases.
Academic Article Role of ß-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.
Academic Article Development and Characterization of Pepducins as Gs-biased Allosteric Agonists.
Academic Article New frontiers in kinases.
Academic Article Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization.
Academic Article Consequence of the tumor-associated conversion to cyclin D1b.
Academic Article Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases.
Academic Article Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.
Academic Article ß-arrestin-biased signaling through the ß2-adrenergic receptor promotes cardiomyocyte contraction.
Academic Article c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.
Grant Training Program in Cellular, Biochemical, and Molecular Sciences
Grant Role of Arrestins in G Protein-Coupled Receptor Regulation
Grant GRC on Second Messengers &Protein Phosphorylation
Grant Short-term Training Students in Health Professional Sch.
Grant ARRESTINS IN G PROTEIN-COUPLE RECEPTOR REGULATION
Grant BETA-ADRENERGIC RECEPTOR REGULATION IN AIRWAY EPITHELIUM
Grant Training Program in Biomolecular Signal Transduction
Grant Arestin Interaction with Endocytic Components
Grant G Protein-Coupled Receptor Kinases
Grant Regulation of CXCR4 Signaling
Academic Article Structural and Functional Analysis of a ß2-Adrenergic Receptor Complex with GRK5.
Academic Article G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin.
Academic Article G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
Grant Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular function
Grant Regulation of G protein-coupled receptor signaling and trafficking
Academic Article Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
Academic Article G protein-coupled receptor kinases: Past, present and future.
Grant Structural and dynamic analysis of GRK interaction with G protein-coupled receptors
Academic Article Pepducin-mediated cardioprotection via ß-arrestin-biased ß2-adrenergic receptor-specific signaling.
Academic Article G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.
Academic Article GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets.
Academic Article Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
Academic Article Historical Perspective of the G Protein-Coupled Receptor Kinase Family.
Academic Article Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors.
Academic Article Phenylalanine 193 in Extracellular Loop 2 of the ß2-Adrenergic Receptor Coordinates ß-Arrestin Interaction.
Academic Article Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma.
Academic Article Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4.
Academic Article Pepducin ICL1-9-Mediated ß2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner.
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