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One or more keywords matched the following items that are connected to Pascal, John
Item TypeName
Concept Adenosine Triphosphatases
Concept Chromosomal Proteins, Non-Histone
Concept Glycoside Hydrolases
Concept HeLa Cells
Concept Histones
Concept Hospitalization
Concept Humans
Concept Kinetics
Concept Protein Kinase C
Concept Sequence Homology, Amino Acid
Concept Cyclic AMP-Dependent Protein Kinases
Concept Mice, Knockout
Concept Protein Kinase Inhibitors
Concept HEK293 Cells
Concept Hydrophobic and Hydrophilic Interactions
Academic Article The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Academic Article Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.
Academic Article Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.
Academic Article Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
Academic Article Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases.
Academic Article Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.
Academic Article Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
Academic Article Dual roles of PARP-1 promote cancer growth and progression.
Academic Article Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.
Academic Article Human DNA ligase I completely encircles and partially unwinds nicked DNA.
Academic Article DNA ligases: structure, reaction mechanism, and function.
Academic Article A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.
Academic Article A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.
Academic Article DNA and RNA ligases: structural variations and shared mechanisms.
Academic Article The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.
Academic Article Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.
Academic Article Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer.
Academic Article Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes.
Academic Article Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.
Academic Article Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.
Academic Article Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Academic Article PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.
Grant Structural Biochemistry of PARP-1
Grant Protein-Protein Interactions in DNA Repair Pathways
Academic Article Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors.
Academic Article Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.
Academic Article Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.
Academic Article The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.
Academic Article Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.
Academic Article Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Academic Article Structural basis for allosteric PARP-1 retention on DNA breaks.
Academic Article A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite Community-Based Cohort Study.
Academic Article Tissue-Specific Regulation of the Wnt/ß-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Academic Article An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIa within a flexible DNA repair complex.
Academic Article The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine.
Academic Article Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
Academic Article Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Academic Article ADP-ribosyltransferases, an update on function and nomenclature.
Academic Article PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.
Academic Article Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results From the MAL-ED Study.
Academic Article Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.
Academic Article HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Academic Article Mechanisms of Nucleosome Reorganization by PARP1.
Academic Article Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
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