Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Pascal, John
Item TypeName
Concept Enzyme Inhibitors
Concept Poly(ADP-ribose) Polymerases
Concept Protein Kinase Inhibitors
Academic Article The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Academic Article Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.
Academic Article Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
Academic Article Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.
Academic Article Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
Academic Article A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.
Academic Article Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
Grant Structural Biochemistry of PARP-1
Academic Article Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.
Academic Article Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors.
Academic Article Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
Academic Article Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Concept Poly (ADP-Ribose) Polymerase-1
Concept Poly(ADP-ribose) Polymerase Inhibitors
Academic Article Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity.
Academic Article Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin.
Academic Article Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
Academic Article Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Academic Article HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Academic Article Mechanisms of Nucleosome Reorganization by PARP1.
Academic Article A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.
Academic Article Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Academic Article Clinical PARP inhibitors allosterically induce PARP2 retention on DNA.
Academic Article Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Search Criteria
  • Poly ADP ribose Polymerase
  • Inhibitors