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Pascal, John
One or more keywords matched the following items that are connected to
Pascal, John
Item Type
Name
Concept
Enzyme Inhibitors
Concept
Poly(ADP-ribose) Polymerases
Concept
Protein Kinase Inhibitors
Academic Article
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Academic Article
Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.
Academic Article
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
Academic Article
Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.
Academic Article
Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
Academic Article
A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.
Academic Article
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
Grant
Structural Biochemistry of PARP-1
Academic Article
Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.
Academic Article
Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors.
Academic Article
Design and Synthesis of Poly(ADP-ribose) polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
Academic Article
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Concept
Poly (ADP-Ribose) Polymerase-1
Concept
Poly(ADP-ribose) Polymerase Inhibitors
Academic Article
Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity.
Academic Article
Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin.
Academic Article
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
Academic Article
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Academic Article
HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Academic Article
Mechanisms of Nucleosome Reorganization by PARP1.
Academic Article
A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.
Academic Article
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Academic Article
Clinical PARP inhibitors allosterically induce PARP2 retention on DNA.
Academic Article
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Search Criteria
Poly ADP ribose Polymerase
Inhibitors