Thomas Jefferson University

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Holinstat, Michael
One or more keywords matched the following items that are connected to Holinstat, Michael
Item TypeName
Concept Blood Platelets
Concept Platelet Adhesiveness
Concept Platelet Aggregation
Concept Platelet Aggregation Inhibitors
Concept Platelet Membrane Glycoproteins
Concept Platelet Activation
Concept Platelet Glycoprotein GPIIb-IIIa Complex
Academic Article Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Academic Article Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Academic Article 12-lipoxygenase: a potential target for novel anti-platelet therapeutics.
Academic Article Rap1-Rac1 circuits potentiate platelet activation.
Academic Article Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Academic Article Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
Academic Article Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation.
Academic Article MicroRNAs in platelet production and activation.
Academic Article PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
Academic Article Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway.
Academic Article PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis.
Academic Article Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.
Academic Article Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Academic Article Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics.
Academic Article Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation.
Academic Article Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis.
Academic Article Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.
Academic Article Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function.
Academic Article 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via Gas Signaling in Platelets.
Grant Genetic regulation of racial differences in platelet reactivity
Grant 12-HETrE regulation of platelets
Grant Thrombin regulation of Rap1 signaling in human platelet activity
Grant Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus
Grant PAR mediated Rap 1 activation in platelets
Grant Thrombin regulation of Rap1 signaling in human platelet activity
Academic Article The expansive role of oxylipins on platelet biology.
Academic Article Normal platelet function.
Academic Article Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.
Academic Article In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.
Academic Article New LINE(s) of Evidence for Genetic Regulation of Platelets.
Academic Article Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy.
Academic Article 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.
Academic Article Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases.
Academic Article Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids.
Academic Article 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Grant 12-HETrE regulation of blood coagulation, hemostasis, and thrombosis
Academic Article Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.
Academic Article Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARa-dependent manner.
Academic Article DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Academic Article GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.
Academic Article Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.
Academic Article Antisense oligonucleotides and nucleic acids generate hypersensitive platelets.
Grant Biomarkers for 12-lipoxygenase inhibition as a therapeutic intervention for heparin-induced thrombocytopenia and thrombosis (HIT/T)
Academic Article Controlling the Clot: ANXA7 Regulates Collagen Activation of Platelet Through 12-LOX.
Academic Article Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Academic Article PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer.
Academic Article Supplementation with omega-3 or omega-6 fatty acids attenuates platelet reactivity in postmenopausal women.
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  • Blood Platelets