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One or more keywords matched the following items that are connected to Holinstat, Michael
Item TypeName
Concept Acoustic Stimulation
Concept Actins
Concept Action Potentials
Concept Adenosine Diphosphate
Concept Animals
Concept Anti-Inflammatory Agents
Concept Antibodies
Concept Arachidonate 12-Lipoxygenase
Concept Auditory Perception
Concept Biological Transport
Concept Blood Coagulation
Concept Blood Platelets
Concept Botulinum Toxins
Concept Breast Neoplasms
Concept Calcium
Concept Capillary Permeability
Concept Chelating Agents
Concept Chiroptera
Concept Chromones
Concept Cytoplasmic Granules
Concept Cytoskeleton
Concept Cytosol
Concept Dipeptides
Concept Dose-Response Relationship, Drug
Concept Echolocation
Concept Egtazic Acid
Concept Electrophoresis, Polyacrylamide Gel
Concept Electrophysiology
Concept Endothelium, Vascular
Concept Enzyme Activation
Concept Enzyme Inhibitors
Concept Fibrinogen
Concept Fibrinolytic Agents
Concept Flow Cytometry
Concept Genes, Dominant
Concept Hemostasis
Concept Hemostatics
Concept Humans
Concept Immunosorbent Techniques
Concept Inferior Colliculi
Concept Intercellular Junctions
Concept Islets of Langerhans
Concept Kinetics
Concept Ligands
Concept Luciferases
Concept Lung
Concept Gas Chromatography-Mass Spectrometry
Concept Microcirculation
Concept Actin Cytoskeleton
Concept Models, Biological
Concept Models, Theoretical
Concept Morpholines
Concept Nadolol
Concept Neoplastic Cells, Circulating
Concept Neoplasm Metastasis
Concept Olivary Nucleus
Concept Phosphatidic Acids
Concept Phosphorylation
Concept Platelet Adhesiveness
Concept Platelet Aggregation
Concept Platelet Aggregation Inhibitors
Concept Platelet Membrane Glycoproteins
Concept Polymers
Concept Precipitin Tests
Concept Propranolol
Concept Protease Inhibitors
Concept Protein Binding
Concept Pseudopodia
Concept Pulmonary Artery
Concept Sheep
Concept Stereoisomerism
Concept Structure-Activity Relationship
Concept Thiazoles
Concept Thrombin
Concept Thromboxane A2
Concept Valproic Acid
Concept Immunoblotting
Concept Blotting, Western
Concept Calcium Channels
Concept Signal Transduction
Concept Down-Regulation
Concept Platelet Activation
Concept Inositol 1,4,5-Trisphosphate
Concept Eicosanoids
Concept Up-Regulation
Concept Case-Control Studies
Concept Integrins
Concept Oligonucleotides, Antisense
Concept Arachidonic Acid
Concept Lipoxygenase Inhibitors
Concept Electric Impedance
Concept Genes, Reporter
Concept Receptors, Purinergic P2
Concept Phosphatidylinositol Phosphates
Concept Receptors, Cytoplasmic and Nuclear
Concept Receptors, Thrombin
Concept Mice, Knockout
Concept Patch-Clamp Techniques
Concept Microscopy, Confocal
Concept Myosin Light Chains
Concept Platelet Glycoprotein GPIIb-IIIa Complex
Concept GTP-Binding Proteins
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept Thapsigargin
Concept 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Concept Phosphatidylinositol 3-Kinases
Concept 1-Butanol
Concept Calcium Signaling
Concept GTP Phosphohydrolases
Concept Guanine Nucleotide Exchange Factors
Concept GTPase-Activating Proteins
Concept rho GTP-Binding Proteins
Concept rhoA GTP-Binding Protein
Concept rap1 GTP-Binding Proteins
Concept rac1 GTP-Binding Protein
Concept Heterotrimeric GTP-Binding Proteins
Concept Protein Transport
Concept Models, Animal
Concept Feedback, Physiological
Concept RNA, Small Interfering
Concept ADP Ribose Transferases
Concept Pertussis Toxin
Concept Endothelial Cells
Concept Receptors, G-Protein-Coupled
Concept GTP-Binding Protein alpha Subunits, Gq-G11
Concept GTP-Binding Protein alpha Subunits, G12-G13
Concept Receptors, Proteinase-Activated
Concept Receptor, PAR-1
Concept Receptor, PAR-2
Concept Cell Line, Tumor
Concept Protein Kinase Inhibitors
Concept Immunoprecipitation
Concept p38 Mitogen-Activated Protein Kinases
Concept Green Fluorescent Proteins
Concept TRPC Cation Channels
Concept Mice
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Focal Adhesion Kinase 1
Concept Cyclooxygenase 1
Concept Protein Kinase C-alpha
Concept Benzophenanthridines
Concept Inositol 1,4,5-Trisphosphate Receptors
Concept rho-Associated Kinases
Concept Group IV Phospholipases A2
Concept Gene Knockdown Techniques
Concept Histone Deacetylase Inhibitors
Concept Neointima
Concept Purinergic P2 Receptor Antagonists
Concept Receptors, Purinergic P2Y12
Concept Transcriptome
Concept B7-H1 Antigen
Concept Matrix Metalloproteinase Inhibitors
Concept MCF-7 Cells
Academic Article Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Academic Article Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Academic Article 12-lipoxygenase: a potential target for novel anti-platelet therapeutics.
Academic Article Rap1-Rac1 circuits potentiate platelet activation.
Academic Article We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs.
Academic Article Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Academic Article Newer agents in antiplatelet therapy: a review.
Academic Article Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
Academic Article MicroRNAs in platelet production and activation.
Academic Article Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function.
Academic Article Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement.
Academic Article RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.
Academic Article Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.
Academic Article Interaural level difference processing in the lateral superior olive and the inferior colliculus.
Academic Article Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.
Academic Article Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.
Academic Article PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
Academic Article G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coupled receptors: evolving concepts and new techniques.
Academic Article Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway.
Academic Article PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis.
Academic Article Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.
Academic Article Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Academic Article Synthesis and Structure-Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase.
Academic Article Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics.
Academic Article The emerging role of oxylipins in thrombosis and diabetes.
Academic Article Racial Differences in Resistance to P2Y12 Receptor Antagonists in Type 2 Diabetic Subjects.
Academic Article Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation.
Academic Article Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and gq signaling axis.
Academic Article Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.
Academic Article Dual antiplatelet therapy for PCI: Are we tailored to all?
Academic Article Development of Poly Unsaturated Fatty Acid Derivatives of Aspirin for Inhibition of Platelet Function.
Academic Article 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via Gas Signaling in Platelets.
Grant 12-HETrE regulation of platelets
Grant Thrombin regulation of Rap1 signaling in human platelet activity
Grant Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus
Grant PAR mediated Rap 1 activation in platelets
Grant Thrombin regulation of Rap1 signaling in human platelet activity
Academic Article The expansive role of oxylipins on platelet biology.
Academic Article Complement factors (H) into thrombosis.
Academic Article Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium.
Academic Article Who is the real 12-HETrE?
Academic Article Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.
Academic Article Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better.
Academic Article First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Academic Article Modified two-step emulsion solvent evaporation technique for fabricating biodegradable rod-shaped particles in the submicron size range.
Academic Article In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.
Academic Article Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy.
Academic Article 12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.
Academic Article Neutrophil-Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation.
Academic Article Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Academic Article Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases.
Academic Article Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2.
Academic Article Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids.
Academic Article KLF11 (Kruüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Academic Article 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Grant NRSA Training Core
Grant 12-HETrE regulation of blood coagulation, hemostasis, and thrombosis
Academic Article Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1ß-driven venous thrombosis.
Academic Article Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish.
Academic Article Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.
Academic Article Resolvin the clot: DVT resolution through RvD4.
Academic Article Biosynthesis of the Maresin Intermediate, 13S,14S-epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and its Regulation through Negative Allosteric Modulators.
Academic Article 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
Academic Article Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice.
Academic Article Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARa-dependent manner.
Academic Article DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Academic Article Popping the lid on PAR4 activation.
Academic Article Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Academic Article GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.
Academic Article Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.
Academic Article Deformable microparticles for shuttling nanoparticles to the vascular wall.
Academic Article E-selectin Inhibitor is Superior to LMWH for Treatment of Experimental Venous Thrombosis.
Grant Biomarkers for 12-lipoxygenase inhibition as a therapeutic intervention for heparin-induced thrombocytopenia and thrombosis (HIT/T)
Academic Article In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.
Academic Article Controlling the Clot: ANXA7 Regulates Collagen Activation of Platelet Through 12-LOX.
Academic Article Slounase, a Batroxobin Containing Activated Factor X Effectively Enhances Hemostatic Clot Formation and Reducing Bleeding in Hypocoagulant Conditions in Mice.
Academic Article Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Academic Article PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer.
Search Criteria
  • Inositol
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  • 5
  • Trisphosphate
  • Receptors