Item Type | Name |
Concept
|
Age Factors
|
Concept
|
Aged
|
Concept
|
Alkylating Agents
|
Concept
|
Alzheimer Disease
|
Concept
|
Amino Acid Sequence
|
Concept
|
Analysis of Variance
|
Concept
|
Animals
|
Concept
|
Antibodies, Monoclonal
|
Concept
|
Antineoplastic Agents
|
Concept
|
Antineoplastic Combined Chemotherapy Protocols
|
Concept
|
Behavior, Animal
|
Concept
|
Cell Compartmentation
|
Concept
|
Cell Differentiation
|
Concept
|
Clinical Trials as Topic
|
Concept
|
Cognition
|
Concept
|
Courtship
|
Concept
|
Disease Models, Animal
|
Concept
|
DNA Repair
|
Concept
|
Dose-Response Relationship, Drug
|
Concept
|
Drosophila
|
Concept
|
Drosophila melanogaster
|
Concept
|
Endocytosis
|
Concept
|
Endoplasmic Reticulum
|
Concept
|
Enzyme Inhibitors
|
Concept
|
Ethylnitrosourea
|
Concept
|
Fluorescent Antibody Technique
|
Concept
|
Fucosyltransferases
|
Concept
|
Humans
|
Concept
|
Immunotherapy
|
Concept
|
Intercellular Junctions
|
Concept
|
Kidney Neoplasms
|
Concept
|
Larva
|
Concept
|
Learning
|
Concept
|
Ligands
|
Concept
|
Lithium
|
Concept
|
Membrane Glycoproteins
|
Concept
|
Memory
|
Concept
|
Middle Aged
|
Concept
|
Models, Biological
|
Concept
|
Molecular Biology
|
Concept
|
Molecular Sequence Data
|
Concept
|
Wilms Tumor
|
Concept
|
Nerve Degeneration
|
Concept
|
Neuromuscular Junction
|
Concept
|
Neuronal Plasticity
|
Concept
|
Phosphorylation
|
Concept
|
Protease Inhibitors
|
Concept
|
Protein Processing, Post-Translational
|
Concept
|
Random Allocation
|
Concept
|
Rats, Inbred Strains
|
Concept
|
Receptors, Cell Surface
|
Concept
|
Endosomes
|
Concept
|
Substrate Specificity
|
Concept
|
Transcription, Genetic
|
Concept
|
Blotting, Western
|
Concept
|
Restriction Mapping
|
Concept
|
Signal Transduction
|
Concept
|
Down-Regulation
|
Concept
|
Cadherins
|
Concept
|
Polymerase Chain Reaction
|
Concept
|
Aspartic Acid Endopeptidases
|
Concept
|
tau Proteins
|
Concept
|
Rats, Sprague-Dawley
|
Concept
|
Cyclic AMP Response Element-Binding Protein
|
Concept
|
Age of Onset
|
Concept
|
Receptors, Metabotropic Glutamate
|
Concept
|
Homeodomain Proteins
|
Concept
|
Patch-Clamp Techniques
|
Concept
|
Trinucleotide Repeats
|
Concept
|
Neurodegenerative Diseases
|
Concept
|
Trinucleotide Repeat Expansion
|
Concept
|
Phosphatidylinositol 3-Kinases
|
Concept
|
Calcium Signaling
|
Concept
|
Genetic Predisposition to Disease
|
Concept
|
Anticipation, Genetic
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
Concept
|
Aquaporins
|
Concept
|
Protein Transport
|
Concept
|
Cytoplasmic Vesicles
|
Concept
|
Models, Animal
|
Concept
|
Tauopathies
|
Concept
|
Drosophila Proteins
|
Concept
|
Caenorhabditis elegans Proteins
|
Concept
|
Animals, Genetically Modified
|
Concept
|
Glycogen Synthase Kinase 3
|
Concept
|
Genomic Instability
|
Concept
|
Ubiquitin-Protein Ligases
|
Concept
|
Cell Proliferation
|
Concept
|
CREB-Binding Protein
|
Concept
|
HSC70 Heat-Shock Proteins
|
Concept
|
Rats
|
Concept
|
Receptors, Notch
|
Concept
|
Inositol 1,4,5-Trisphosphate Receptors
|
Concept
|
Presenilins
|
Concept
|
Presenilin-1
|
Concept
|
Neurogenesis
|
Concept
|
Unfolded Protein Response
|
Academic Article
|
Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.
|
Academic Article
|
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
|
Academic Article
|
Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.
|
Academic Article
|
Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila.
|
Academic Article
|
Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
|
Academic Article
|
Introduction--Notch in development and disease.
|
Academic Article
|
Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila.
|
Academic Article
|
Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.
|
Academic Article
|
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.
|
Academic Article
|
Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
|
Academic Article
|
Human neurodegenerative disease modeling using Drosophila.
|
Academic Article
|
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.
|
Academic Article
|
Neurobiology: double trouble for neurons.
|
Academic Article
|
PAR-1 for the course of neurodegeneration.
|
Academic Article
|
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
|
Academic Article
|
Notch signaling: a different sort makes the cut.
|
Academic Article
|
gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.
|
Academic Article
|
Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.
|
Academic Article
|
gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.
|
Academic Article
|
Medicine. Anticipating trouble from gene transcription.
|
Academic Article
|
A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila.
|
Academic Article
|
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
|
Academic Article
|
The big brain aquaporin is required for endosome maturation and notch receptor trafficking.
|
Academic Article
|
Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006.
|
Academic Article
|
Inheritance of susceptibility to induction of nephroblastomas in the Noble rat.
|
Academic Article
|
Endocytic regulation of Notch signaling.
|
Academic Article
|
Notch signaling: the core pathway and its posttranslational regulation.
|
Academic Article
|
Generation and characterization of monoclonal antibodies specific to Drosophila presenilin.
|
Academic Article
|
Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling.
|
Academic Article
|
Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-ß Precursor-Like Protein Activity.
|
Grant
|
Novel role of an aquaporin in endosome biogenesis and Notch signaling
|
Grant
|
Regulated proteolysis in developmental signaling
|
Grant
|
ALZHEIMER'S DISEASE RELATED PRESENILINS
|
Grant
|
ACTIVITY OF THE ALZHEIMERS DISEASE PRESENIL IN PROTEIN
|
Grant
|
Identification and characterization of new mutants affecting Notch trafficking
|
Grant
|
Trafficking and Proteolysis of Notch and Other Gamma-Secretase Substrates
|
Grant
|
Identification and characterization of new mutants affecting Notch trafficking
|
Grant
|
Novel role of an aquaporin in endosome biogenesis and Notch signaling
|