Thomas Jefferson University

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Riobo, Natalia
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overview The Hedgehog family of ligands regulates a plethora of biological processes involved in embryonic development, tissue homeostasis and regeneration, and cancer progression. The canonical Hedgehog pathway is based on a series of de-repression events mediated by the proteins Patched, Smoothened, and Su(Fu) that allow a tightly controlled activation of the downstream transcription factors Gli1, Gli2, and Gli3. We and others have recently shown that Hedgehog, signaling through Smoothened, also activates Gi proteins/GRK2/arrestin, PI3K/Akt, and ERK signaling pathways which may have physiological significance on their own. In addition, Patched directly regulates cell cycle progression in a Hedgehog-dependent manner. These newly discovered events are grouped into the so-called non-canonical Hedgehog pathway.
One or more keywords matched the following items that are connected to Riobo, Natalia
Item TypeName
Concept Protein Precursors
Concept Recombinant Proteins
Concept Repressor Proteins
Concept Oncogene Proteins
Concept Protein Structure, Tertiary
Concept Cyclic AMP-Dependent Protein Kinases
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept rho GTP-Binding Proteins
Concept rhoA GTP-Binding Protein
Concept rac GTP-Binding Proteins
Concept rac1 GTP-Binding Protein
Concept Heterotrimeric GTP-Binding Proteins
Concept Receptors, G-Protein-Coupled
Concept GTP-Binding Protein alpha Subunits, G12-G13
Concept Protein Kinase C-delta
Concept Hedgehog Proteins
Academic Article Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways.
Academic Article Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.
Academic Article The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.
Academic Article Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins.
Academic Article Noncanonical Hedgehog signaling.
Academic Article Smoothened is a fully competent activator of the heterotrimeric g protein gi.
Academic Article Receptors coupled to heterotrimeric G proteins of the G12 family.
Academic Article Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling.
Academic Article Hedgehog signal transduction: signal integration and cross talk in development and cancer.
Academic Article Activation of heterotrimeric G proteins by Smoothened.
Academic Article Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells.
Academic Article Pathways of signal transduction employed by vertebrate Hedgehogs.
Academic Article Purification and bioassay of hedgehog ligands for the study of cell death and survival.
Academic Article Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.
Academic Article Patched-1 proapoptotic activity is downregulated by modification of k1413 by the e3 ubiquitin-protein ligase itchy homolog.
Academic Article Evaluating the Activity of Smoothened Toward G Proteins Using [(35)S]Guanosine 5'-(3-O-thio)triphosphate ([ (35)S]GTP?S).
Academic Article Posttranslational Modifications and Secretion of the Hedgehog (Hh) Proteins. Preface.
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  • GTP Binding Proteins