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One or more keywords matched the following properties of Simone, Nicole
keywords Cancer, Breast
overview Dr. Simone is an expert in using dietary alteration to increase the effectiveness of cytotoxic therapy, such as radiation and chemotherapy, in breast and prostate cancer in both the laboratory and clinic. Her research interest is to change the landscape of cancer care by empowering patients to use dietary interventions to improve outcomes. The overarching goal of the Simone laboratory, is to increase the radiation sensitivity of tumors with a poor response to standard therapies. To accomplish this, the lab uses diet to alter cell metabolism via signaling pathways to increase cancer cells’ vulnerability to cytotoxic therapy. Through the laboratory studies, new strategies for treating radiation resistant tumors, which has led to the development of innovative clinical trials. Dr. Simone is the Co-Leader of the Breast Cancer Research Program for the Sidney Kimmel Cancer Center and the Margaret Q. Landenberger Endowed Associate Professor in the Department of Radiation Oncology at Thomas Jefferson University. She has considerable experience in translational research, medical treatment, education and training. I joined the Jefferson faculty after a position as an Assistant Clinical Investigator at the National Cancer Institute. Dr. Simone’s laboratory has contributed significantly to studying regulation of microRNAs and the downstream effects of microRNAs on cell metabolism via dietary alterations. Her laboratory demonstrated for the first time that caloric restriction (CR) modifies microRNA expression (Ørom et al., Cell Cycle, 2012). The Simone laboratory then explored the physiologic impact of CR and demonstrated that CR can augment radiation therapy (Saleh et al., Cell Cycle, 2013), which she then translated directly into a clinical trial using diet during radiation for early stage breast cancer patients (NCT01819233). The lab found the same improved physiologic response of the primary tumor in vivo when CR was combined with chemotherapy, which was translated directly to a clinical trial (NCT02827370). Dr. Simone’s laboratory also investigated the role of microRNAs in the ability of CR to decrease metastatic disease burden via control of the ECM (Jin et al., Breast Cancer Res Treat, 2014; Simone et al., Cell Cycle, 2016) which is being considered as a NRG Oncology clinical trial concept. These findings led to her third IIT in which diet modulation prior to definitive oncologic surgery for patients with endometrial, prostate, and breast cancer will be evaluated to favorably alter expression of microRNAs as drivers of cancer progression (NCT02983279).
One or more keywords matched the following items that are connected to Simone, Nicole
Item TypeName
Concept Breast Neoplasms
Academic Article Twenty-five year results of the national cancer institute randomized breast conservation trial.
Academic Article Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data?
Academic Article Radiation therapy for locally recurrent breast cancer.
Academic Article Caloric restriction augments radiation efficacy in breast cancer.
Academic Article The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster.
Academic Article Intraoperative radiotherapy for breast cancer: the lasting effects of a fleeting treatment.
Academic Article Active Breathing Coordinator reduces radiation dose to the heart and preserves local control in patients with left breast cancer: Report of a prospective trial.
Academic Article Caloric restriction coupled with radiation decreases metastatic burden in triple negative breast cancer.
Academic Article NRG Oncology-Radiation Therapy Oncology Group Study 1014: 1-Year Toxicity Report From a Phase 2 Study of Repeat Breast-Preserving Surgery and 3-Dimensional Conformal Partial-Breast Reirradiation for In-Breast Recurrence.
Academic Article Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model.
Academic Article Re: Elevated BMI might more significantly affect the outcome negatively in luminal type breast cancer patients with brain metastases.
Academic Article Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer.
Academic Article Increases in Tumor N-Glycan Polylactosamines Associated with Advanced HER2-Positive and Triple-Negative Breast Cancer Tissues.
Academic Article Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis.
Academic Article Concerns for activated breathing control (ABC) with breast cancer in the era of COVID-19: Maximizing infection control while minimizing heart dose.
Academic Article Dosimetric Comparisons of Simulation Techniques for Left-Sided Breast Cancer in the COVID-19 Era: Techniques to Reduce Viral Transmission and Respect the Therapeutic Ratio.
Academic Article miR-21 Plays a Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors.
Academic Article Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer.
Academic Article Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology.
Academic Article Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer.
Academic Article A novel method for measuring the burden of breast cancer in neighborhoods.
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  • Breast Neoplasms