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Transcriptional regulation of cytokine functions in airway cells. ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules which may in turn orchestrate and perpetuate the disease process in asthma. Our goals are to identify intracellular signaling pathways by which cytokines modulate or induce these cellular responses. A focus of this project is to investigate the transcriptional and post-transcriptional mechanisms regulating cytokine functions in ASM cells.