Thomas Jefferson University

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Pasinelli, Piera
One or more keywords matched the following items that are connected to Pasinelli, Piera
Item TypeName
Concept Amyotrophic Lateral Sclerosis
Concept Motor Neuron Disease
Academic Article ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
Academic Article Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
Academic Article Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.
Academic Article Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.
Academic Article An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.
Academic Article Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.
Academic Article Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis.
Academic Article Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease.
Academic Article Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity.
Academic Article Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.
Academic Article RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.
Academic Article Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.
Academic Article Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.
Academic Article Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
Academic Article The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis.
Academic Article A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.
Academic Article Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.
Academic Article Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.
Academic Article ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis.
Academic Article Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.
Academic Article Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Academic Article Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.
Academic Article Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis.
Academic Article Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers.
Academic Article Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis.
Academic Article Targeting TNFa produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.
Academic Article A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.
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  • Motor Neuron Disease