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One or more keywords matched the following items that are connected to Pestell, Richard
Item TypeName
Concept Animals
Concept Disease Models, Animal
Concept Mammary Glands, Animal
Concept Mammary Neoplasms, Animal
Concept Animals, Genetically Modified
Academic Article c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
Academic Article 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors.
Academic Article Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten(+/-) preclinical mouse model.
Academic Article microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.
Academic Article Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".
Academic Article ErbB2 induces Notch1 activity and function in breast cancer cells.
Academic Article The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Academic Article Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.
Academic Article Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Academic Article CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway.
Academic Article Dietary restriction: standing up for sirtuins.
Academic Article Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Academic Article Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal microenvironment.
Academic Article The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
Academic Article HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Academic Article C-jun inhibits mammary apoptosis in vivo.
Academic Article Cell fate determination factor Dachshund reprograms breast cancer stem cell function.
Academic Article Alternative cyclin D1 splice forms differentially regulate the DNA damage response.
Academic Article The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.
Academic Article Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.
Academic Article Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts.
Academic Article The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
Academic Article Acetylation and nuclear receptor action.
Academic Article Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation.
Academic Article PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b.
Academic Article MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals.
Academic Article Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment.
Academic Article c-Jun is required for TGF-ß-mediated cellular migration via nuclear Ca²? signaling.
Academic Article Mechanisms for progenitor cell-mediated repair for ischemic heart injury.
Academic Article The type 1 insulin-like growth factor receptor and resistance to DACH1.
Academic Article Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator.
Academic Article Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.
Academic Article Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine.
Academic Article Examining the role of cyclin D1 in breast cancer.
Academic Article Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis.
Academic Article Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Academic Article SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.
Academic Article Mammary gland selective excision of c-jun identifies its role in mRNA splicing.
Academic Article Breast cancer stem cells.
Academic Article ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.
Academic Article Small non-coding RNAs govern mammary gland tumorigenesis.
Academic Article Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration.
Academic Article Cyclin d1 induces chromosomal instability.
Academic Article CCR5 antagonist blocks metastasis of basal breast cancer cells.
Academic Article CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
Academic Article Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug.
Academic Article Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.
Academic Article The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.
Academic Article E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination.
Academic Article Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
Academic Article Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence.
Academic Article Senescence and epigenetic dysregulation in cancer.
Academic Article ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.
Academic Article In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb.
Academic Article Recent advances in inducible expression in transgenic mice.
Academic Article Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.
Academic Article Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
Academic Article Acetylation in hormone signaling and the cell cycle.
Academic Article Spatially discrete, light-driven protein expression.
Academic Article Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.
Academic Article Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis.
Academic Article Amino acids regulate hepatocyte proliferation through modulation of cyclin D1 expression.
Academic Article Gene expression phenotypic models that predict the activity of oncogenic pathways.
Academic Article BRCA1 gene in breast cancer.
Academic Article Cyclin D1 governs adhesion and motility of macrophages.
Academic Article The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Academic Article Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.
Academic Article Nuclear receptor modifications and endocrine cell proliferation.
Academic Article Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.
Academic Article Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
Academic Article BRCA1 in hormone-responsive cancers.
Academic Article p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.
Academic Article AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.
Academic Article Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth.
Academic Article BRCA1 inhibition of telomerase activity in cultured cells.
Academic Article Intestinal tumor progression is associated with altered function of KLF5.
Academic Article 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB.
Academic Article Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes.
Academic Article Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Academic Article The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity.
Academic Article Signal transduction inhibitors in cellular function.
Academic Article The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements.
Academic Article Acetylation of nuclear receptors in cellular growth and apoptosis.
Academic Article Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.
Academic Article Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells.
Academic Article Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling.
Academic Article Minireview: Cyclin D1: normal and abnormal functions.
Academic Article Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Academic Article Caveolin-1 in breast cancer.
Academic Article SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Academic Article Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.
Academic Article Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose.
Academic Article Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
Academic Article Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice.
Academic Article Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment.
Academic Article beta-catenin signaling and regulation of cyclin D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidase.
Academic Article 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation.
Academic Article Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling.
Academic Article Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation.
Academic Article Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells.
Academic Article Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness.
Academic Article Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Academic Article Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling.
Academic Article Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA.
Academic Article Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.
Academic Article Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.
Academic Article SIRT1 and endocrine signaling.
Academic Article Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Academic Article Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.
Academic Article Cyclin D1 determines mitochondrial function in vivo.
Academic Article Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function.
Academic Article Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1.
Academic Article Antisense to cyclin D1 inhibits VEGF-stimulated growth of vascular endothelial cells: implication of tumor vascularization.
Academic Article Hormonal control of androgen receptor function through SIRT1.
Academic Article p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.
Academic Article DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.
Academic Article Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection.
Academic Article Cyclin D1 induction of cellular migration requires p27(KIP1).
Academic Article Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
Academic Article Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection.
Academic Article Cyclin D1 functions in cell migration.
Academic Article Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers.
Academic Article Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.
Academic Article Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Academic Article Epigenetics and the estrogen receptor.
Academic Article The functional significance of nuclear receptor acetylation.
Academic Article Akt1 governs breast cancer progression in vivo.
Academic Article ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
Academic Article High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
Academic Article Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression.
Academic Article Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration.
Academic Article Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.
Academic Article Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts.
Academic Article Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.
Academic Article Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.
Academic Article Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts.
Academic Article A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
Academic Article Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.
Academic Article Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.
Academic Article MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma.
Academic Article Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders.
Academic Article Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions.
Academic Article Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.
Academic Article Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
Academic Article Altered expression of DACH1 and cyclin D1 in endometrial cancer.
Academic Article PPARgamma activation induces autophagy in breast cancer cells.
Academic Article p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.
Academic Article The Dachshund gene in development and hormone-responsive tumorigenesis.
Academic Article Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Academic Article The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.
Academic Article Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.
Academic Article Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products.
Grant BREAST INDUCIBLE ANTISENSE CYCLIN D1 TRANSGENIC MICE
Grant REGULATION OF CYCLIN D1 EXPRESSION
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