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Pestell, Richard
One or more keywords matched the following items that are connected to Pestell, Richard
Item TypeName
Concept Breast Neoplasms
Concept Breast Neoplasms, Male
Academic Article c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
Academic Article microRNA, cell cycle, and human breast cancer.
Academic Article Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells.
Academic Article microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling.
Academic Article Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".
Academic Article ErbB2 induces Notch1 activity and function in breast cancer cells.
Academic Article Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.
Academic Article Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Academic Article Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Academic Article Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Academic Article Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal microenvironment.
Academic Article The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
Academic Article HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Academic Article Cell fate determination factor Dachshund reprograms breast cancer stem cell function.
Academic Article Alternative cyclin D1 splice forms differentially regulate the DNA damage response.
Academic Article Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
Academic Article Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.
Academic Article The role of breast cancer stem cells in metastasis and therapeutic implications.
Academic Article Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.
Academic Article Examining the role of cyclin D1 in breast cancer.
Academic Article Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".
Academic Article Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells.
Academic Article Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors.
Academic Article Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment.
Academic Article Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
Academic Article Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Academic Article Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.
Academic Article Breast cancer stem cells.
Academic Article ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.
Academic Article Small non-coding RNAs govern mammary gland tumorigenesis.
Academic Article CCR5 antagonist blocks metastasis of basal breast cancer cells.
Academic Article Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.
Academic Article CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
Academic Article Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug.
Academic Article Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1a and HIF2a in tumor-associated fibroblasts and human breast cancer cells.
Academic Article Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
Academic Article EYA1 Phosphatase Function Is Essential to Drive Breast Cancer Cell Proliferation through Cyclin D1.
Academic Article Caloric restriction augments radiation efficacy in breast cancer.
Academic Article Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer.
Academic Article p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Academic Article Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.
Academic Article Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Academic Article Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.
Academic Article BRCA1 gene in breast cancer.
Academic Article The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Academic Article Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.
Academic Article BRCA1 in hormone-responsive cancers.
Academic Article p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.
Academic Article AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.
Academic Article BRCA1 inhibition of telomerase activity in cultured cells.
Academic Article Altered Rho GTPase signaling pathways in breast cancer cells.
Academic Article The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements.
Academic Article Caveolin-1 in breast cancer.
Academic Article Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.
Academic Article Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose.
Academic Article Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.
Academic Article Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.
Academic Article Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity.
Academic Article Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.
Academic Article Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.
Academic Article Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.
Academic Article Regulation of progesterone receptor signaling by BRCA1 in mammary cancer.
Academic Article DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.
Academic Article Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers.
Academic Article The functional significance of nuclear receptor acetylation.
Academic Article Akt1 governs breast cancer progression in vivo.
Academic Article Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1.
Academic Article Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR.
Academic Article Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.
Academic Article Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8.
Academic Article A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
Academic Article Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
Academic Article Cancer stem cells and the cell cycle: targeting the drive behind breast cancer.
Academic Article Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders.
Academic Article Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation.
Academic Article Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
Academic Article An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.
Academic Article Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy.
Academic Article Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer.
Academic Article PPARgamma activation induces autophagy in breast cancer cells.
Academic Article The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling.
Academic Article p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.
Academic Article BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha.
Academic Article The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.
Academic Article Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.
Academic Article Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer.
Academic Article Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.
Academic Article CAPER, a novel regulator of human breast cancer progression.
Academic Article miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1.
Academic Article Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer.
Academic Article pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.
Academic Article BRCA1 inhibition of estrogen receptor signaling in transfected cells.
Academic Article Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression.
Academic Article The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
Academic Article The mammary gland iodide transporter is expressed during lactation and in breast cancer.
Academic Article Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.
Academic Article Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Academic Article Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.
Academic Article Rhenium-188 as an alternative to Iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS).
Academic Article Nutritional modulation of the cell cycle and breast cancer.
Academic Article miR-221/222 Promotes S-Phase Entry and Cellular Migration in Control of Basal-Like Breast Cancer.
Academic Article The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster.
Academic Article Acetylation-defective mutant of Ppar? is associated with decreased lipid synthesis in breast cancer cells.
Academic Article The potential to target CCL5/CCR5 in breast cancer.
Academic Article BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion.
Academic Article EglN2 associates with the NRF1-PGC1a complex and controls mitochondrial function in breast cancer.
Academic Article Mitochondrial mass and DNA repair in breast cancer stem cells.
Academic Article Breast Cancer Stem Cell Isolation.
Academic Article Cancer stem cell metabolism.
Academic Article A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer.
Academic Article The CCL5/CCR5 axis promotes metastasis in basal breast cancer.
Grant BREAST INDUCIBLE ANTISENSE CYCLIN D1 TRANSGENIC MICE
Grant Cyclin D1 Regulation of Nuclear Receptor Function in Breast Cancer
Grant Caveolin-1 and Cyclin D1 in Mammary Tumorigenesis
Grant REGULATION OF CYCLIN D1 EXPRESSION
Grant DACH1/Eya Cell fate determination factor and mammary tumorigenesis
Grant Initiation and Maintenance in Mammary Tumorigenesis
Grant Impact of Cyclin D1 Isoforms in Breast Cancer
Academic Article DACH1 suppresses breast cancer as a negative regulator of CD44.
Academic Article CCR5 governs DNA damage and breast cancer stem cell expansion.
Academic Article Recent advances of highly selective CDK4/6 inhibitors in breast cancer.
Academic Article Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth.
Academic Article Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome.
Academic Article MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer.
Academic Article Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology.
Concept Triple Negative Breast Neoplasms
Grant CCR5 inhibitors to enhance therapeutic response of breast cancer to DNA damaging agents
Academic Article Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy.
Academic Article piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
Academic Article Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors.
Academic Article The Renaissance of CDK Inhibitors in Breast Cancer Therapy: An Update on Clinical Trials and Therapy Resistance.
Academic Article High PD-L2 Predicts Early Recurrence of ER-Positive Breast Cancer.
Academic Article Regulation of ERa-dependent breast cancer metastasis by a miR-29a signaling.
Academic Article The Role and Therapeutic Targeting of CCR5 in Breast Cancer.
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  • Breast Neoplasms