Thomas Jefferson University

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Pestell, Richard
One or more keywords matched the following items that are connected to Pestell, Richard
Item TypeName
Concept Cells, Cultured
Concept Tumor Cells, Cultured
Academic Article Alternative cyclin D1 splice forms differentially regulate the DNA damage response.
Academic Article c-Jun is required for TGF-ß-mediated cellular migration via nuclear Ca²? signaling.
Academic Article CCR5 antagonist blocks metastasis of basal breast cancer cells.
Academic Article Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Academic Article p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Academic Article Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1.
Academic Article The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.
Academic Article Interferon-beta activates multiple signaling cascades in primary human microglia.
Academic Article Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.
Academic Article Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.
Academic Article Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
Academic Article Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells.
Academic Article Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Academic Article Role of BRCA1 in heat shock response.
Academic Article Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1.
Academic Article Amino acids regulate hepatocyte proliferation through modulation of cyclin D1 expression.
Academic Article Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells.
Academic Article BRCA1 inhibition of telomerase activity in cultured cells.
Academic Article Altered Rho GTPase signaling pathways in breast cancer cells.
Academic Article Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Academic Article Acetylation of nuclear receptors in cellular growth and apoptosis.
Academic Article Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells.
Academic Article Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Academic Article SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Academic Article Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.
Academic Article Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
Academic Article Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.
Academic Article Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling.
Academic Article Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells.
Academic Article Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness.
Academic Article Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA.
Academic Article Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Academic Article Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function.
Academic Article DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth.
Academic Article Akt1 governs breast cancer progression in vivo.
Academic Article DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells.
Academic Article Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase.
Academic Article Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy.
Academic Article MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma.
Academic Article Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.
Academic Article Epidermal growth factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter.
Academic Article Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: evidence for the involvement of protein kinase C.
Academic Article Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways.
Academic Article Cyclin D1 is required for S phase traversal in bovine tracheal myocytes.
Academic Article Adrenocorticotropin induction of stress-activated protein kinase in the adrenal cortex in vivo.
Academic Article The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells.
Academic Article Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism.
Academic Article Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.
Academic Article Catalytic activation of extracellular signal-regulated kinases induces cyclin D1 expression in primary tracheal myocytes.
Academic Article Fos family members induce cell cycle entry by activating cyclin D1.
Academic Article Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes.
Academic Article pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.
Academic Article BRCA1 inhibition of estrogen receptor signaling in transfected cells.
Academic Article Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1).
Academic Article NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
Academic Article Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
Academic Article Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA.
Academic Article Stat3 as an oncogene.
Academic Article Caveolin-1 potentiates estrogen receptor alpha (ERalpha) signaling. caveolin-1 drives ligand-independent nuclear translocation and activation of ERalpha.
Academic Article Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
Academic Article Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.
Academic Article Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.
Academic Article Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression.
Academic Article p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.
Academic Article Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif.
Academic Article The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
Academic Article Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation.
Academic Article Regulation of cyclin D(1) expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells.
Academic Article Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein.
Academic Article Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation.
Academic Article Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Academic Article Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.
Academic Article Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner.
Academic Article Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes.
Academic Article Ras regulation of cyclin D1 promoter.
Academic Article Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
Academic Article A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.
Academic Article Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.
Academic Article Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding.
Academic Article Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-Ras.
Academic Article Ligand-independent activation of oestrogen receptor alpha by caveolin-1.
Academic Article Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Grant Cyclin D1 Regulation of Nuclear Receptor Function in Breast Cancer
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