Epilepsy, Generalized

"Epilepsy, Generalized" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Recurrent conditions characterized by epileptic seizures which arise diffusely and simultaneously from both hemispheres of the brain. Classification is generally based upon motor manifestations of the seizure (e.g., convulsive, nonconvulsive, akinetic, atonic, etc.) or etiology (e.g., idiopathic, cryptogenic, and symptomatic). (From Mayo Clin Proc, 1996 Apr;71(4):405-14)

Descriptor ID	D004829
MeSH Number(s)	C10.228.140.490.375
Concept/Terms	Epilepsy, Generalized Epilepsy, Generalized Epilepsies, Generalized Generalized Epilepsies Generalized Epilepsy Seizure Disorder, Generalized Generalized Seizure Disorder Generalized Seizure Disorders Seizure Disorders, Generalized Epilepsy, Akinetic Epilepsy, Akinetic Akinetic Epilepsies Akinetic Epilepsy Epilepsies, Akinetic Symptomatic Generalized Epilepsy Symptomatic Generalized Epilepsy Epilepsy, Symptomatic Generalized Generalized Epilepsy, Symptomatic Epilepsy, Tonic Epilepsy, Tonic Epilepsies, Tonic Tonic Epilepsies Tonic Epilepsy Generalized Nonconvulsive Seizure Disorder Generalized Nonconvulsive Seizure Disorder Generalized Seizure Disorder, Nonconvulsive Seizure Disorder, Nonconvulsive Generalized Nonconvulsive Seizure Disorder, Generalized Seizure Disorder, Generalized Nonconvulsive Generalized Nonconvulsive Epilepsy Epilepsy, Generalized Nonconvulsive Nonconvulsive Epilepsy, Generalized Nonconvulsive Generalized Seizure Disorder Convulsive Generalized Seizure Disorder Convulsive Generalized Seizure Disorder Generalized Convulsive Epilepsy Convulsive Epilepsies, Generalized Convulsive Epilepsy, Generalized Epilepsies, Generalized Convulsive Epilepsy, Generalized Convulsive Generalized Convulsive Epilepsies Generalized Onset Seizure Disorder Seizure Disorder, Convulsive, Generalized Seizure Disorder, Generalized Onset Seizure Disorder, Generalized, Convulsive Convulsive Seizure Disorder, Generalized Generalized Seizure Disorder, Convulsive Epilepsy, Atonic Epilepsy, Atonic Atonic Epilepsies Atonic Epilepsy Epilepsies, Atonic

Below are MeSH descriptors whose meaning is more general than "Epilepsy, Generalized".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Epilepsy [C10.228.140.490]
Epilepsy, Generalized [C10.228.140.490.375]

Below are MeSH descriptors whose meaning is related to "Epilepsy, Generalized".

Below are MeSH descriptors whose meaning is more specific than "Epilepsy, Generalized".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epilepsy, Generalized" by people in this website by year, and whether "Epilepsy, Generalized" was a major or minor topic of these publications.

Bar chart showing 27 publications over 14 distinct years, with a maximum of 6 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2003	1	0	1
2005	1	0	1
2006	2	0	2
2007	1	0	1
2012	3	0	3
2013	2	0	2
2014	2	0	2
2015	1	0	1
2016	1	0	1
2018	0	1	1
2020	0	1	1
2021	3	1	4
2022	6	0	6

Below are the most recent publications written about "Epilepsy, Generalized" by people in Profiles.

Wheless JW, Friedman D, Krauss GL, Rao VR, Sperling MR, Carrazana E, Rabinowicz AL. Future opportunities for research in rescue treatments. Epilepsia. 2022 09; 63 Suppl 1:S55-S68.

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Misra SN, Sperling MR, Rao VR, Peters JM, Davis C, Carrazana E, Rabinowicz AL. Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. Epilepsia. 2022 10; 63(10):2684-2693.

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Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Mosh? SL, Tinuper P, Wirrell EC. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 06; 63(6):1475-1499.

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Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL. Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4?h for acute treatment of seizure clusters: A population analysis. Epilepsia. 2022 07; 63(7):1714-1723.

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Schwarz N, Seiffert S, Pendziwiat M, Rademacher AV, Br?nger T, Hedrich UBS, Augustijn PB, Baier H, Bayat A, Bisulli F, Buono RJ, Bruria BZ, Doyle MG, Guerrini R, Heimer G, Iacomino M, Kearney H, Klein KM, Kousiappa I, Kunz WS, Lerche H, Licchetta L, Lohmann E, Minardi R, McDonald M, Montgomery S, Mulahasanovic L, Oegema R, Ortal B, Papacostas SS, Ragona F, Granata T, Reif PS, Rosenow F, Rothschild A, Scudieri P, Striano P, Tinuper P, Tanteles GA, Vetro A, Zahnert F, Goldberg EM, Zara F, Lal D, May P, Muhle H, Helbig I, Weber Y. Spectrum of Phenotypic, Genetic, and Functional Characteristics in Patients With Epilepsy With KCNC2 Pathogenic Variants. Neurology. 2022 05 17; 98(20):e2046-e2059.

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Sperling MR, Wheless JW, Hogan RE, Dlugos D, Cascino GD, Liow K, Rabinowicz AL, Carrazana E. Use of second doses of Valtoco? (diazepam nasal spray) across 24?hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study. Epilepsia. 2022 04; 63(4):836-843.

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Buono RJ, Bradfield JP, Wei Z, Sperling MR, Dlugos DJ, Privitera MD, French JA, Lo W, Cossette P, Schachter SC, Basehore H, Lohoff FW, Grant SFA, Ferraro TN, Hakonarson H. Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy. Genes (Basel). 2021 09 18; 12(9).

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Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E. Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. Epilepsia. 2021 10; 62(10):2485-2495.

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Tarighati Rasekhi R, Devlin KN, Mass JA, Donmez M, Asma B, Sperling MR, Nei M. Improving prediction of sudden unexpected death in epilepsy: From SUDEP-7 to SUDEP-3. Epilepsia. 2021 07; 62(7):1536-1545.

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Heron SE, Regan BM, Harris RV, Gardner AE, Coleman MJ, Bennett MF, Grinton BE, Helbig KL, Sperling MR, Haut S, Geller EB, Widdess-Walsh P, Pelekanos JT, Bahlo M, Petrovski S, Heinzen EL, Hildebrand MS, Corbett MA, Scheffer IE, G?cz J, Berkovic SF. Association of SLC32A1 Missense Variants With Genetic Epilepsy With Febrile Seizures Plus. Neurology. 2021 05 04; 96(18):e2251-e2260.

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