Epistasis, Genetic

"Epistasis, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.

Descriptor ID	D004843
MeSH Number(s)	G05.308.207
Concept/Terms	Epistasis, Genetic Epistasis, Genetic Epistases, Genetic Gene-Gene Interactions, Epistatic Gene Gene Interactions, Epistatic Gene-Gene Interaction, Epistatic Epistatic Gene-Gene Interaction Epistatic Gene-Gene Interactions Gene Gene Interaction, Epistatic Interaction, Epistatic Gene-Gene Interactions, Epistatic Gene-Gene Non-Allelic Gene Interactions Gene Interaction, Non-Allelic Gene Interactions, Non-Allelic Interaction, Non-Allelic Gene Interactions, Non-Allelic Gene Non Allelic Gene Interactions Non-Allelic Gene Interaction Genetic Epistasis Genetic Epistases Genes, Epistatic Genes, Epistatic Epistatic Gene Epistatic Genes Gene, Epistatic Genes, Hypostatic Genes, Hypostatic Gene, Hypostatic Hypostatic Gene Hypostatic Genes Deviation, Epistatic Deviation, Epistatic Interaction Deviation Epistatic Deviation

Below are MeSH descriptors whose meaning is more general than "Epistasis, Genetic".

Biological Sciences [G]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Epistasis, Genetic [G05.308.207]

Below are MeSH descriptors whose meaning is more specific than "Epistasis, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epistasis, Genetic" by people in this website by year, and whether "Epistasis, Genetic" was a major or minor topic of these publications.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 2000 and 2003 and 2005 and 2008 and 2009 and 2011 and 2016 and 2019 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2005	0	1	1
2008	1	0	1
2009	1	0	1
2011	0	1	1
2016	1	0	1
2019	0	1	1
2025	1	0	1

Below are the most recent publications written about "Epistasis, Genetic" by people in Profiles.

Rayinda T, Dand N, McSweeney SM, Christou E, Ung CY, Stefanato CM, Fenton DA, Harries M, Palamaras I, Tidman A, Holmes S, Koutalopoulou A, Ardern-Jones M, Kaur M, Papanikou S, Chasapi V, Va??-Galvan S, Saceda-Corralo D, Meli?n-Olivera A, Azcarraga-Llobet C, Lobato-Berezo A, Bustamante M, Sunyer J, Starace MVR, Piraccini BM, Wiss IP, Senna MM, Singh R, Hillmann K, Kanti-Schmidt V, Blume-Peytavi U, McGrath JA, Simpson MA, Tziotzios C. Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis. JAMA Dermatol. 2025 03 01; 161(3):310-314.

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Heindl JE, Crosby D, Brar S, Pinto JF, Singletary T, Merenich D, Eagan JL, Buechlein AM, Bruger EL, Waters CM, Fuqua C. Reciprocal control of motility and biofilm formation by the PdhS2 two-component sensor kinase of Agrobacterium tumefaciens. Microbiology (Reading). 2019 02; 165(2):146-162.

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Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD. Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium. PLoS Genet. 2016 09; 12(9):e1006186.

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Jun G, Nicolaou M, Morrison MA, Buros J, Morgan DJ, Radeke MJ, Yonekawa Y, Tsironi EE, Kotoula MG, Zacharaki F, Mollema N, Yuan Y, Miller JW, Haider NB, Hageman GS, Kim IK, Schaumberg DA, Farrer LA, DeAngelis MM. Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology. PLoS One. 2011; 6(10):e25775.

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Jeon S, Choi JY, Lee KM, Park SK, Yoo KY, Noh DY, Ahn SH, Kang D. Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer. Breast Cancer Res Treat. 2010 Jun; 121(3):737-42.

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Lodhi N, Ranjan A, Singh M, Srivastava R, Singh SP, Chaturvedi CP, Ansari SA, Sawant SV, Tuli R. Interactions between upstream and core promoter sequences determine gene expression and nucleosome positioning in tobacco PR-1a promoter. Biochim Biophys Acta. 2008 Oct; 1779(10):634-44.

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Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, Honjo T. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med. 2005 Dec 19; 202(12):1643-8.

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Cook R, Lu L, Gu J, Williams RW, Smeyne RJ. Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res. 2003 Feb 20; 110(2):279-88.

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Bolland S, Ravetch JV. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity. 2000 Aug; 13(2):277-85.

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