"Colforsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
| Descriptor ID |
D005576
|
| MeSH Number(s) |
D02.455.849.291.300
|
| Concept/Terms |
Colforsin- Colforsin
- N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl
- Coleonol
- Forskolin
|
Below are MeSH descriptors whose meaning is more general than "Colforsin".
Below are MeSH descriptors whose meaning is more specific than "Colforsin".
This graph shows the total number of publications written about "Colforsin" by people in this website by year, and whether "Colforsin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Colforsin" by people in Profiles.
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Koziol-White C, Johnstone TB, Corpuz ML, Cao G, Orfanos S, Parikh V, Deeney B, Tliba O, Ostrom RS, Dainty I, Panettieri RA. Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L345-L355.
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Mack SG, Cook DJ, Dhurjati P, Butchbach ME. Systems biology investigation of cAMP modulation to increase SMN levels for the treatment of spinal muscular atrophy. PLoS One. 2014; 9(12):e115473.
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Chahdi A, Sorokin A. Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol. 2008 Mar; 28(5):1679-87.
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Ramesh Babu PB, Chidekel A, Utidjian L, Shaffer TH. Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3. Biochem Biophys Res Commun. 2004 Jul 09; 319(4):1132-7.
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Chen H, Tliba O, Van Besien CR, Panettieri RA, Amrani Y. TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. J Appl Physiol (1985). 2003 Aug; 95(2):864-72; discussion 863.
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Gaballa MA, Eckhart A, Koch WJ, Goldman S. Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1129-35.
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Yu X, Zhang M, Kyker K, Patterson E, Benovic JL, Kem DC. Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors. Circulation. 2000 Nov 14; 102(20):2535-40.
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Xu X, Rials SJ, Wu Y, Liu T, Marinchak RA, Kowey PR. Effects of captopril treatment of renovascular hypertension on beta-adrenergic modulation of L-type Ca(2+) current. J Pharmacol Exp Ther. 2000 Jan; 292(1):196-200.
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Billington CK, Hall IP, Mundell SJ, Parent JL, Panettieri RA, Benovic JL, Penn RB. Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. Am J Respir Cell Mol Biol. 1999 Nov; 21(5):597-606.
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Fukayama S, Kong G, Benovic JL, Meurer E, Tashjian AH. Beta-adrenergic receptor kinase-1 acutely regulates PTH/PTHrP receptor signalling in human osteoblastlike cells. Cell Signal. 1997 Sep; 9(6):469-74.