"Freeze Etching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.
| Descriptor ID |
D005613
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| MeSH Number(s) |
E01.370.225.500.620.620.260.400 E01.370.225.750.600.620.260.400 E05.200.500.620.620.260.400 E05.200.750.600.620.260.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Freeze Etching".
Below are MeSH descriptors whose meaning is more specific than "Freeze Etching".
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Below are the most recent publications written about "Freeze Etching" by people in Profiles.
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Janoff AS, Boni LT, Popescu MC, Minchey SR, Cullis PR, Madden TD, Taraschi T, Gruner SM, Shyamsunder E, Tate MW, et al. Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):6122-6.
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Maul GG, Steplewski Z, Weibel J, Koprowski H. Time sequence and morphological evaluations of cells fused by polyethylene glycol 6000(1). In Vitro. 1976 Nov; 12(11):787-96.
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Maul GG, Maul HM, Scogna JE, Lieberman MW, Stein GS, Hsu BY, Borun TW. Time sequence of nuclear pore formation in phytohemagglutinin-stimulated lymphocytes and in HeLa cells during the cell cycle. J Cell Biol. 1972 Nov; 55(2):433-47.