"Glutamate-Ammonia Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
| Descriptor ID |
D005974
|
| MeSH Number(s) |
D08.811.464.259.200.600
|
| Concept/Terms |
Glutamate-Ammonia Ligase- Glutamate-Ammonia Ligase
- Glutamate Ammonia Ligase
- Ligase, Glutamate-Ammonia
- Glutamate Ammonia Ligase (ADP)
- Glutamine Synthetase
- Synthetase, Glutamine
|
Below are MeSH descriptors whose meaning is more general than "Glutamate-Ammonia Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Ammonia Ligase".
This graph shows the total number of publications written about "Glutamate-Ammonia Ligase" by people in this website by year, and whether "Glutamate-Ammonia Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glutamate-Ammonia Ligase" by people in Profiles.
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Palmieri EM, Menga A, Mart?n-P?rez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesqui?re B, McVicar DW, Guarini A, Mazzone M, Castegna A. Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. Cell Rep. 2017 08 15; 20(7):1654-1666.
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Palmieri EM, Menga A, Lebrun A, Hooper DC, Butterfield DA, Mazzone M, Castegna A. Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells. Antioxid Redox Signal. 2017 03 10; 26(8):351-363.
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Castegna A, Palmieri L, Spera I, Porcelli V, Palmieri F, Fabis-Pedrini MJ, Kean RB, Barkhouse DA, Curtis MT, Hooper DC. Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis. Neuroscience. 2011 Jun 30; 185:97-105.
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Lichtenstein GR, Yang YX, Nunes FA, Lewis JD, Tuchman M, Tino G, Kaiser LR, Palevsky HI, Kotloff RM, Furth EE, Bavaria JE, Stecker MM, Kaplan P, Berry GT. Fatal hyperammonemia after orthotopic lung transplantation. Ann Intern Med. 2000 Feb 15; 132(4):283-7.
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Tuchman M, Lichtenstein GR, Rajagopal BS, McCann MT, Furth EE, Bavaria J, Kaplan PB, Gibson JB, Berry GT. Hepatic glutamine synthetase deficiency in fatal hyperammonemia after lung transplantation. Ann Intern Med. 1997 Sep 15; 127(6):446-9.
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Funanage VL, Ayling PD, Dendinger SM, Brenchley JE. Salmonella typhimurium LT-2 mutants with altered glutamine synthetase levels and amino acid uptake activities. J Bacteriol. 1978 Nov; 136(2):588-96.
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Funanage VL, Brenchley JE. Characterization of Salmonella typhimurium mutants with altered glutamine synthetase activity. Genetics. 1977 Jul; 86(3):513-26.