"Hirudins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
| Descriptor ID |
D006629
|
| MeSH Number(s) |
D12.644.861.060.875 D12.776.872.060.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hirudins".
Below are MeSH descriptors whose meaning is more specific than "Hirudins".
This graph shows the total number of publications written about "Hirudins" by people in this website by year, and whether "Hirudins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Hirudins" by people in Profiles.
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Weeks P, Sieg A, Rajapreyar I, Nathan S, Jumean M, Patel M, Radovancevic R, Kar B, Gregoric I. Bivalirudin for left ventricular assist device thrombosis. J Thromb Thrombolysis. 2018 Nov; 46(4):496-501.
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Gajanana D, Weintraub WS, Kolm P, Rogers T, Iantorno M, Buchanan KD, Ben-Dor I, Pichard AD, Satler LF, Thourani VH, Torguson R, Okubagzi PG, Waksman R. The impact of in-hospital P2Y12 inhibitor switch in patients with acute coronary syndrome. Cardiovasc Revasc Med. 2018 12; 19(8):912-916.
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Sirker A, Mamas M, Robinson D, Anderson SG, Kinnaird T, Stables R, de Belder MA, Ludman P, Hildick-Smith D. Bivalirudin, glycoprotein inhibitor, and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom. Eur Heart J. 2016 Apr 21; 37(16):1312-20.
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Sangani NK, Greason KL, Torres NE, Suri RM, Mathew V. Bivalirudin and transcatheter aortic valve replacement: a cautionary tale. Ann Thorac Surg. 2014 Dec; 98(6):2214-5.
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Pericleous A, Sadek M, Fitzmaurice M, Caldwell C, Natividad K, Plestis KA. Anticoagulation with bivalirudin during deep hypothermic circulatory arrest in a patient with heparin-induced thrombocytopenia. Tex Heart Inst J. 2014 Dec; 41(6):645-8.
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Holinstat M, Colowick NE, Hudson WJ, Blakemore D, Chen Q, Hamm HE, Cleator JH. Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation. J Thromb Thrombolysis. 2013 Feb; 35(2):209-22.
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Rao SV, Dai D, Subherwal S, Weintraub WS, Brindis RS, Messenger JC, Lopes RD, Peterson ED. Association between periprocedural bleeding and long-term outcomes following percutaneous coronary intervention in older patients. JACC Cardiovasc Interv. 2012 Sep; 5(9):958-65.
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Orkic Z, Mraovic B, Kvolik S, Istvanic T, Divkovic D, Kristek J. Does the type of anesthesia administered affect the efficacy of medicinal leech therapy after finger replantation: clinical observations in a 6-year-old boy. Paediatr Anaesth. 2012 Jun; 22(6):605-7.
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Diercks DB, Pollack CV, Hollander JE, Blomkalns AL, Emerman CL, Rokos IC, Larson DM, Hoekstra JW, Mehran R, Stone GW. The time dependence of antithrombin initiation in patients with non-ST-segment elevation acute coronary syndromes: subgroup analysis from the ACUITY trial. Ann Emerg Med. 2011 Mar; 57(3):204-212.e1-6.
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Hong MS, Amanullah AM. Heparin-induced thrombocytopenia: a practical review. Rev Cardiovasc Med. 2010; 11(1):13-25.