Ketone Bodies

"Ketone Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The metabolic substances ACETONE; 3-HYDROXYBUTYRIC ACID; and acetoacetic acid (ACETOACETATES). They are produced in the liver and kidney during FATTY ACIDS oxidation and used as a source of energy by the heart, muscle and brain.

Descriptor ID	D007657
MeSH Number(s)	D02.522.585
Concept/Terms	Ketone Bodies Ketone Bodies Bodies, Ketone Acetone Bodies Acetone Bodies Bodies, Acetone

Below are MeSH descriptors whose meaning is more general than "Ketone Bodies".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Ketones [D02.522]
Ketone Bodies [D02.522.585]

Below are MeSH descriptors whose meaning is related to "Ketone Bodies".

Below are MeSH descriptors whose meaning is more specific than "Ketone Bodies".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ketone Bodies" by people in this website by year, and whether "Ketone Bodies" was a major or minor topic of these publications.

Bar chart showing 15 publications over 9 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2011	0	2	2
2012	1	3	4
2013	0	1	1
2014	0	1	1
2017	1	1	2
2018	1	0	1
2020	0	1	1
2024	2	0	2

Below are the most recent publications written about "Ketone Bodies" by people in Profiles.

Foster MW, Riley JM, Kaki PC, Al Soueidy A, Aligholiazadeh E, Rame JE. Metabolic Adaptation in Heart Failure and the Role of Ketone Bodies as Biomarkers. Curr Heart Fail Rep. 2024 Oct; 21(5):498-503.

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Gulette GA, Hass DT, Pandey K, Zhang Q, Han JYS, Engel A, Chao JR, Philp NJ, Hurley JB, Miller JML. Reassessing retinal pigment epithelial ketogenesis: Enzymatic assays for ketone body levels provide inaccurate results. Exp Eye Res. 2024 08; 245:109966.

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Moellmann J, Klinkhammer BM, Droste P, Kappel B, Haj-Yehia E, Maxeiner S, Artati A, Adamski J, Boor P, Sch?tt K, Lopaschuk GD, Verma S, Marx N, Lehrke M. Empagliflozin improves left ventricular diastolic function of db/db mice. Biochim Biophys Acta Mol Basis Dis. 2020 08 01; 1866(8):165807.

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Sikder K, Shukla SK, Patel N, Singh H, Rafiq K. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-?. Cell Physiol Biochem. 2018; 48(3):1317-1331.

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Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U. Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. Semin Oncol. 2017 06; 44(3):198-203.

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Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K. HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. Sci Rep. 2017 07 04; 7(1):4590.

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Martinez-Outschoorn UE, Peiris-Pag?s M, Pestell RG, Sotgia F, Lisanti MP. Cancer metabolism: a therapeutic perspective. Nat Rev Clin Oncol. 2017 Jan; 14(1):11-31.

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Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014 Dec; 55(12):2458-70.

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Curry JM, Tuluc M, Whitaker-Menezes D, Ames JA, Anantharaman A, Butera A, Leiby B, Cognetti DM, Sotgia F, Lisanti MP, Martinez-Outschoorn UE. Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer. Cell Cycle. 2013 May 01; 12(9):1371-84.

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Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle. 2013 Jan 01; 12(1):172-82.

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