Lymphocyte Culture Test, Mixed
"Lymphocyte Culture Test, Mixed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
| Descriptor ID |
D007959
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| MeSH Number(s) |
E01.370.225.812.385.475 E05.200.812.385.475 E05.478.594.385.429
|
| Concept/Terms |
Lymphocyte Culture Test, Mixed- Lymphocyte Culture Test, Mixed
- Leukocyte Culture Test, Mixed
- Mixed Lymphocyte Reaction
- Lymphocyte Reaction, Mixed
- Lymphocyte Reactions, Mixed
- Mixed Lymphocyte Reactions
- Mixed Leukocyte Reaction
- Leukocyte Reaction, Mixed
- Leukocyte Reactions, Mixed
- Mixed Leukocyte Reactions
- Mixed Leukocyte Culture Test
- Mixed Lymphocyte Culture Test
|
Below are MeSH descriptors whose meaning is more general than "Lymphocyte Culture Test, Mixed".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Culture Test, Mixed".
This graph shows the total number of publications written about "Lymphocyte Culture Test, Mixed" by people in this website by year, and whether "Lymphocyte Culture Test, Mixed" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lymphocyte Culture Test, Mixed" by people in Profiles.
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Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. Int Immunol. 2014 Jul; 26(7):357-67.
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Gibson HM, Mishra A, Chan DV, Hake TS, Porcu P, Wong HK. Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for S?zary syndrome. J Invest Dermatol. 2013 Jan; 133(1):249-57.
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Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, Markovic-Plese S. B cells as a therapeutic target for IFN-? in relapsing-remitting multiple sclerosis. J Immunol. 2011 Apr 01; 186(7):4518-26.
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Bamboat ZM, Stableford JA, Plitas G, Burt BM, Nguyen HM, Welles AP, Gonen M, Young JW, DeMatteo RP. Human liver dendritic cells promote T cell hyporesponsiveness. J Immunol. 2009 Feb 15; 182(4):1901-11.
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Peng X, Jin J, Giri S, Montes M, Sujkowski D, Tang Y, Smrtka J, Vollmer T, Singh I, Markovic-Plese S. Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis. J Neuroimmunol. 2006 Sep; 178(1-2):130-9.
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Dranitzki-Elhalel M, Huang JH, Rachmilewitz J, Pappo O, Parnas M, Schmidt W, Tykocinski ML. CTLA-4.FasL inhibits allogeneic responses in vivo. Cell Immunol. 2006 Feb; 239(2):129-35.
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Yamazaki S, Patel M, Harper A, Bonito A, Fukuyama H, Pack M, Tarbell KV, Talmor M, Ravetch JV, Inaba K, Steinman RM. Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2758-63.
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Ramsborg CG, Windgassen D, Fallon JK, Paredes CJ, Papoutsakis ET. Molecular insights into the pleiotropic effects of plasma on ex vivo-expanded T cells using DNA-microarray analysis. Exp Hematol. 2004 Oct; 32(10):970-90.
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Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. J Immunol. 2003 Jun 15; 170(12):5842-50.
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Storozynsky E, Woodward JG, Frelinger JG, Lord EM. Interleukin-3 and granulocyte-macrophage colony-stimulating factor enhance the generation and function of dendritic cells. Immunology. 1999 May; 97(1):138-49.