Leydig Cell Tumor

"Leydig Cell Tumor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Gonadal interstitial or stromal cell neoplasm composed of only LEYDIG CELLS. These tumors may produce one or more of the steroid hormones such as ANDROGENS; ESTROGENS; and CORTICOSTEROIDS. Clinical symptoms include testicular swelling, GYNECOMASTIA, sexual precocity in children, or virilization (VIRILISM) in females.

Descriptor ID	D007984
MeSH Number(s)	C04.557.475.750.847.249 C04.588.322.762.500.249 C04.588.945.440.915.500.249 C12.294.260.937.500.249 C12.758.409.937.500.249 C19.344.762.500.249 C19.391.829.782.500.249
Concept/Terms	Leydig Cell Tumor Leydig Cell Tumor Tumor, Leydig Cell Interstitial Cell Tumor Interstitial Cell Tumors Tumor, Interstitial Cell Tumors, Interstitial Cell

Below are MeSH descriptors whose meaning is more general than "Leydig Cell Tumor".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Neoplasms, Gonadal Tissue [C04.557.475]
Sex Cord-Gonadal Stromal Tumors [C04.557.475.750]
Sertoli-Leydig Cell Tumor [C04.557.475.750.847]
Leydig Cell Tumor [C04.557.475.750.847.249]
Neoplasms by Site [C04.588]
Endocrine Gland Neoplasms [C04.588.322]
Testicular Neoplasms [C04.588.322.762]
Sertoli-Leydig Cell Tumor [C04.588.322.762.500]
Leydig Cell Tumor [C04.588.322.762.500.249]
Urogenital Neoplasms [C04.588.945]
Genital Neoplasms, Male [C04.588.945.440]
Testicular Neoplasms [C04.588.945.440.915]
Sertoli-Leydig Cell Tumor [C04.588.945.440.915.500]
Leydig Cell Tumor [C04.588.945.440.915.500.249]
Male Urogenital Diseases [C12]
Genital Diseases, Male [C12.294]
Genital Neoplasms, Male [C12.294.260]
Testicular Neoplasms [C12.294.260.937]
Sertoli-Leydig Cell Tumor [C12.294.260.937.500]
Leydig Cell Tumor [C12.294.260.937.500.249]
Urogenital Neoplasms [C12.758]
Genital Neoplasms, Male [C12.758.409]
Testicular Neoplasms [C12.758.409.937]
Sertoli-Leydig Cell Tumor [C12.758.409.937.500]
Leydig Cell Tumor [C12.758.409.937.500.249]
Endocrine System Diseases [C19]
Endocrine Gland Neoplasms [C19.344]
Testicular Neoplasms [C19.344.762]
Sertoli-Leydig Cell Tumor [C19.344.762.500]
Leydig Cell Tumor [C19.344.762.500.249]
Gonadal Disorders [C19.391]
Testicular Diseases [C19.391.829]
Testicular Neoplasms [C19.391.829.782]
Sertoli-Leydig Cell Tumor [C19.391.829.782.500]
Leydig Cell Tumor [C19.391.829.782.500.249]

Below are MeSH descriptors whose meaning is related to "Leydig Cell Tumor".

Below are MeSH descriptors whose meaning is more specific than "Leydig Cell Tumor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leydig Cell Tumor" by people in this website by year, and whether "Leydig Cell Tumor" was a major or minor topic of these publications.

Bar chart showing 7 publications over 5 distinct years, with a maximum of 2 publications in 2010 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2004	1	0	1
2010	2	0	2
2017	1	0	1
2021	2	0	2

Below are the most recent publications written about "Leydig Cell Tumor" by people in Profiles.

Golmard L, Vasta LM, Duflos V, Corsini C, Dubois d'Enghien C, McMaster ML, Harney LA, Carr AG, Ling A, Dijoud F, Gauthier A, Miettinen M, Cost NG, Gauthier-Villars M, Orbach D, Irtan S, Haouy S, Schultz KA, Stoppa-Lyonnet D, Coupier I, Stewart DR, Sirvent N. Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome. J Med Genet. 2022 04; 59(4):346-350.

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Kruslin B, Gatalica Z, Hes O, Skenderi F, Miettinen M, Contreras E, Xiu J, Ellis M, Florento E, Vranic S, Swensen J. TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors. Clin Genitourin Cancer. 2021 08; 19(4):333-338.

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Mark JR, Gomella LG. Nonpalpable Intratesticular Mass in a Young Man With a History of Contralateral Retractile Testis. Oncology (Williston Park). 2017 06 15; 31(6):484, 489-91.

View in: PubMed
Fishman MD, Eisenberg DA, Horrow MM. Klinefelter syndrome with leydig cell tumor/hyperplasia. Ultrasound Q. 2010 Jun; 26(2):101-2.

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Fan J, Traore K, Li W, Amri H, Huang H, Wu C, Chen H, Zirkin B, Papadopoulos V. Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells. Endocrinology. 2010 Jul; 151(7):3348-62.

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Li W, Amri H, Huang H, Wu C, Papadopoulos V. Gene and protein profiling of the response of MA-10 Leydig tumor cells to human chorionic gonadotropin. J Androl. 2004 Nov-Dec; 25(6):900-13.

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Iczkowski KA, Bostwick DG, Roche PC, Cheville JC. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998 Aug; 11(8):774-9.

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Ayalon D, Graif M, Hetman-Peri M, Abramowicz J, Eckstein N, Vagman I, Papo J, Itzhak Y, Caspi E. Diagnosis of a small ovarian tumor (androgen secreting) by magnetic resonance: a new noninvasive procedure. Am J Obstet Gynecol. 1988 Oct; 159(4):903-5.

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Russell JB, Lambert SJ, Taylor KJ, DeCherney AH. Androgen-producing hilus cell tumor of the ovary. Detection in a postmenopausal woman by duplex Doppler scanning. JAMA. 1987 Feb 20; 257(7):962-3.

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Miettinen M, Wahlstrom T, Virtanen I, Talerman A, Astengo-Osuna C. Cellular differentiation in ovarian sex-cord-stromal and germ-cell tumors studied with antibodies to intermediate-filament proteins. Am J Surg Pathol. 1985 Sep; 9(9):640-51.

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