Lipoproteins, HDL

"Lipoproteins, HDL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

Descriptor ID	D008075
MeSH Number(s)	D10.532.432 D12.776.521.479
Concept/Terms	Lipoproteins, HDL Lipoproteins, HDL HDL Lipoproteins Heavy Lipoproteins Lipoproteins, Heavy High-Density Lipoproteins High Density Lipoproteins Lipoproteins, High-Density alpha-Lipoproteins alpha Lipoproteins alpha-1 Lipoprotein alpha-1 Lipoprotein

Below are MeSH descriptors whose meaning is more general than "Lipoproteins, HDL".

Chemicals and Drugs [D]
Lipids [D10]
Lipoproteins [D10.532]
Lipoproteins, HDL [D10.532.432]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Lipoproteins [D12.776.521]
Lipoproteins, HDL [D12.776.521.479]

Below are MeSH descriptors whose meaning is related to "Lipoproteins, HDL".

Below are MeSH descriptors whose meaning is more specific than "Lipoproteins, HDL".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lipoproteins, HDL" by people in this website by year, and whether "Lipoproteins, HDL" was a major or minor topic of these publications.

Bar chart showing 35 publications over 19 distinct years, with a maximum of 4 publications in 2018 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	1	0	1
2001	2	0	2
2003	0	1	1
2005	2	0	2
2006	0	1	1
2008	1	2	3
2010	1	1	2
2011	0	1	1
2012	2	1	3
2013	2	1	3
2016	1	0	1
2017	1	0	1
2018	3	1	4
2019	1	0	1
2020	1	1	2
2021	0	1	1
2024	1	3	4
2025	1	0	1

Below are the most recent publications written about "Lipoproteins, HDL" by people in Profiles.

Rodriguez A, Yu M, Phoo MT, Holinstat M, Schwendeman A. Antiplatelet Effects of DMPC-Based Synthetic High-Density Lipoproteins: Exploring Particle Structure and Noncholesterol Efflux Mechanisms. Mol Pharm. 2025 03 03; 22(3):1305-1317.

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Gibson CM, Duffy D, Bahit MC, Chi G, White H, Korjian S, Alexander JH, Lincoff AM, Heise M, Kingwell BA, Nicolau JC, Lopes RD, Cornel JH, Lewis BS, Vinereanu D, Goodman SG, Bode C, Steg PG, Libby P, Sacks FM, Bainey KR, Ridker PM, Mahaffey KW, Aylward P, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA. Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial. Eur Heart J. 2024 12 16; 45(47):5023-5038.

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Gibson CM, Chi G, Duffy D, Bahit MC, White H, Korjian S, Alexander JH, Lincoff AM, Anschuetz G, Girgis IG, Nicolau JC, Lopes RD, Cornel JH, Bainey KR, Libby P, Sacks FM, Ridker PM, Goodman SG, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA. ApoA-I Infusions and Burden of Ischemic Events After Acute Myocardial Infarction: Insights?From the AEGIS-II Trial. J Am Coll Cardiol. 2024 Nov 26; 84(22):2185-2192.

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Gibson CM, Duffy D, Korjian S, Bahit MC, Chi G, Alexander JH, Lincoff AM, Heise M, Tricoci P, Deckelbaum LI, Mears SJ, Nicolau JC, Lopes RD, Merkely B, Lewis BS, Cornel JH, Trebacz J, Parkhomenko A, Libby P, Sacks FM, Povsic TJ, Bonaca M, Goodman SG, Bhatt DL, Tendera M, Steg PG, Ridker PM, Aylward P, Kastelein JJP, Bode C, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA. Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction. N Engl J Med. 2024 05 02; 390(17):1560-1571.

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Povsic TJ, Korjian S, Bahit MC, Chi G, Duffy D, Alexander JH, Vinereanu D, Tricoci P, Mears SJ, Deckelbaum LI, Bonaca M, Ridker PM, Goodman SG, Cornel JH, Lewis BS, Parkhomenko A, Lopes RD, Aylward P, Lincoff AM, Heise M, Sacks F, Nicolau JC, Merkely B, Trebacz J, Libby P, Nicholls SJ, Pocock S, Bhatt DL, Kastelein J, Bode C, Mahaffey KW, Steg PG, Tendera M, Bainey KR, Harrington RA, Mehran R, Duerschmied D, Kingwell BA, Gibson CM. Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors?of Acute MI. J Am Coll Cardiol. 2024 Jun 04; 83(22):2163-2174.

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Sands BE, Colombel JF, Ha C, Farnier M, Armuzzi A, Quirk D, Friedman GS, Kwok K, Salese L, Su C, Taub PR. Lipid Profiles in Patients With Ulcerative Colitis Receiving Tofacitinib-Implications for Cardiovascular Risk and Patient Management. Inflamm Bowel Dis. 2021 05 17; 27(6):797-808.

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He H, Adili R, Liu L, Hong K, Holinstat M, Schwendeman A. Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice. Sci Adv. 2020 12; 6(49).

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Gibson CM, Kastelein JJP, Phillips AT, Aylward PE, Yee MK, Tendera M, Nicholls SJ, Pocock S, Goodman SG, Alexander JH, Lincoff AM, Bode C, Duffy D, Heise M, Berman G, Mears SJ, Tricoci P, Deckelbaum LI, Steg PG, Ridker P, Mehran R. Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction. Am Heart J. 2021 01; 231:121-127.

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Wilkins JT, Gidding SS, Robinson JG. Can atherosclerosis be cured? Curr Opin Lipidol. 2019 12; 30(6):477-484.

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Gibson CM, Kerneis M, Yee MK, Daaboul Y, Korjian S, Mehr AP, Tricoci P, Alexander JH, Kastelein JJP, Mehran R, Bode C, Lewis BS, Mehta R, Duffy D, Feaster J, Halabi M, Angiolillo DJ, Duerschmied D, Ophuis TO, Merkely B. The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction. Am Heart J. 2019 02; 208:81-90.

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