Inactivation, Metabolic

"Inactivation, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.

Descriptor ID	D008658
MeSH Number(s)	G03.171.450 G03.787.225.450 G07.690.725.225.450
Concept/Terms	Inactivation, Metabolic Inactivation, Metabolic Metabolic Inactivation Metabolic Detoxication, Drug Metabolic Detoxication, Drug Detoxication, Drug Metabolic Drug Metabolic Detoxication Drug Detoxication, Metabolic Detoxication, Metabolic Drug Metabolic Drug Detoxication Metabolic Detoxification, Drug Detoxification, Drug Metabolic Drug Metabolic Detoxification Detoxification, Drug, Metabolic Detoxication, Drug, Metabolic Metabolic Drug Inactivation Metabolic Drug Inactivation Drug Inactivation, Metabolic Inactivation, Metabolic Drug

Below are MeSH descriptors whose meaning is more general than "Inactivation, Metabolic".

Biological Sciences [G]
Metabolism [G03]
Biotransformation [G03.171]
Inactivation, Metabolic [G03.171.450]
Pharmacokinetics [G03.787]
Biotransformation [G03.787.225]
Inactivation, Metabolic [G03.787.225.450]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacokinetics [G07.690.725]
Biotransformation [G07.690.725.225]
Inactivation, Metabolic [G07.690.725.225.450]

Below are MeSH descriptors whose meaning is related to "Inactivation, Metabolic".

Below are MeSH descriptors whose meaning is more specific than "Inactivation, Metabolic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inactivation, Metabolic" by people in this website by year, and whether "Inactivation, Metabolic" was a major or minor topic of these publications.

Bar chart showing 11 publications over 10 distinct years, with a maximum of 2 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	0	1	1
2004	1	0	1
2006	0	1	1
2008	0	1	1
2009	0	1	1
2010	1	1	2
2018	1	0	1
2019	1	0	1
2022	1	0	1

Below are the most recent publications written about "Inactivation, Metabolic" by people in Profiles.

Redding MC, Pan JH, Kim YJ, Batish M, Trabulsi J, Lee JH, Kim JK. Apiaceous vegetables protect against acrolein-induced pulmonary injuries through modulating hepatic detoxification and inflammation in C57BL/6 male mice. J Nutr Biochem. 2022 03; 101:108939.

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Nichols RG, Peters JM, Patterson AD. Interplay Between the Host, the Human Microbiome, and Drug Metabolism. Hum Genomics. 2019 06 11; 13(1):27.

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Kisor DF, Bodzin AS. Pharmacogenomics in liver transplantation: testing the recipient and the ex-vivo donor liver. Pharmacogenomics. 2018 06 01; 19(9):753-756.

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Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff M, Hortobagyi GN, Hayes DF, Ambrosone CB. Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res. 2010 Dec 15; 16(24):6169-76.

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Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 2011 Mar; 120 Suppl 1:S49-75.

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Costantino CL, Witkiewicz AK, Kuwano Y, Cozzitorto JA, Kennedy EP, Dasgupta A, Keen JC, Yeo CJ, Gorospe M, Brody JR. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res. 2009 Jun 01; 69(11):4567-72.

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Kraft WK, Gibson E, Dysart K, Damle VS, Larusso JL, Greenspan JS, Moody DE, Kaltenbach K, Ehrlich ME. Sublingual buprenorphine for treatment of neonatal abstinence syndrome: a randomized trial. Pediatrics. 2008 Sep; 122(3):e601-7.

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Slatter JG, Templeton IE, Castle JC, Kulkarni A, Rushmore TH, Richards K, He Y, Dai X, Cheng OJ, Caguyong M, Ulrich RG. Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome. Xenobiotica. 2006 Oct-Nov; 36(10-11):938-62.

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Langmann T, Moehle C, Mauerer R, Scharl M, Liebisch G, Zahn A, Stremmel W, Schmitz G. Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology. 2004 Jul; 127(1):26-40.

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Drucker P, Tepper S. Daily sumatriptan for detoxification from rebound. Headache. 1998 Oct; 38(9):687-90.

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