"Mexiletine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
| Descriptor ID |
D008801
|
| MeSH Number(s) |
D02.092.831.500 D02.455.426.559.389.657.654.675
|
| Concept/Terms |
KO-1173- KO-1173
- KO 1173
- KO1173
- KOE-1173
- KOE 1173
- KOE1173
|
Below are MeSH descriptors whose meaning is more general than "Mexiletine".
Below are MeSH descriptors whose meaning is more specific than "Mexiletine".
This graph shows the total number of publications written about "Mexiletine" by people in this website by year, and whether "Mexiletine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mexiletine" by people in Profiles.
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Olleik F, Kamareddine MH, Spears J, Tse G, Liu T, Yan GX. Mexiletine: Antiarrhythmic mechanisms, emerging clinical applications and mortality. Pacing Clin Electrophysiol. 2023 11; 46(11):1348-1356.
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Liu G, Xue X, Gao C, Huang J, Qi D, Zhang Y, Dong JZ, Ma CS, Yan GX. Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation. J Am Heart Assoc. 2017 May 18; 6(5).
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Qi D, Yang Z, Robinson VM, Li J, Gao C, Guo D, Kowey PR, Yan GX. Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarization. Heart Rhythm. 2015 Jun; 12(6):1295-303.
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Gao Y, Xue X, Hu D, Liu W, Yuan Y, Sun H, Li L, Timothy KW, Zhang L, Li C, Yan GX. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome. Circ Arrhythm Electrophysiol. 2013 Jun; 6(3):614-22.
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Marmura MJ. Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias. Curr Pain Headache Rep. 2010 Apr; 14(2):145-50.
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Marmura MJ, Passero FC, Young WB. Mexiletine for refractory chronic daily headache: a report of nine cases. Headache. 2008 Nov-Dec; 48(10):1506-10.
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Schere D, Silberstein SD. Intravenous lidocaine infusion for the treatment of post-acoustic neuroma resection headache: a case report. Headache. 2009 Feb; 49(2):302-3.
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Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S. Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec; 11(12):1320-9.
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Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation. 1998 Nov 24; 98(21):2314-22.
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Sicouri S, Antzelevitch D, Heilmann C, Antzelevitch C. Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome. J Cardiovasc Electrophysiol. 1997 Nov; 8(11):1280-90.