"Oligomycins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).
| Descriptor ID |
D009840
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| MeSH Number(s) |
D02.540.505.620
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Oligomycins".
Below are MeSH descriptors whose meaning is more specific than "Oligomycins".
This graph shows the total number of publications written about "Oligomycins" by people in this website by year, and whether "Oligomycins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Oligomycins" by people in Profiles.
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Pucci B, Bertani F, Karpinich NO, Indelicato M, Russo MA, Farber JL, Tafani M. Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF. J Cell Physiol. 2008 Nov; 217(2):442-9.
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Hongpaisan J, Winters CA, Andrews SB. Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons. J Neurosci. 2004 Dec 01; 24(48):10878-87.
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Simbula G, Glascott PA, Akita S, Hoek JB, Farber JL. Two mechanisms by which ATP depletion potentiates induction of the mitochondrial permeability transition. Am J Physiol. 1997 Aug; 273(2 Pt 1):C479-88.
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Snyder JW, Pastorino JG, Thomas AP, Hoek JB, Farber JL. ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide. Am J Physiol. 1993 Mar; 264(3 Pt 1):C709-14.
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Sakaida I, Kyle ME, Farber JL. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Mol Pharmacol. 1990 Mar; 37(3):435-42.
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Masaki N, Thomas AP, Hoek JB, Farber JL. Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization. Arch Biochem Biophys. 1989 Jul; 272(1):152-61.
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Lee NH, Shapiro IM. A method for isolating respiring mitochondria from epiphyseal cartilage. Anal Biochem. 1974 Mar; 58(1):117-22.