"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
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| MeSH Number(s) |
D08.811.520.224.125.425
|
| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer. 2006 May 01; 118(9):2344-9.
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Guo Y, Zhao J, Sawicki J, Peralta Soler A, O'Brien TG. Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression. Mol Carcinog. 1999 Sep; 26(1):32-6.
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Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, Gaubatz S, Zhang H, Prochownik E, Eilers M, Prendergast GC. Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 1999 Jun 17; 18(24):3564-73.
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Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, Klein-Szanto AJ, Gilmour SK. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res. 1997 Jun 01; 57(11):2104-8.
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Megosh L, Gilmour SK, Rosson D, Soler AP, Blessing M, Sawicki JA, O'Brien TG. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res. 1995 Oct 01; 55(19):4205-9.
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Gunnia UB, Amenta PS, Seibold JR, Thomas TJ. Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. Kidney Int. 1991 May; 39(5):882-90.
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Siracusa LD, Jenkins NA, Copeland NG. Identification and applications of repetitive probes for gene mapping in the mouse. Genetics. 1991 Jan; 127(1):169-79.
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Herrera L, Petrelli N. Ornithine decarboxylase activity in hepatic and extrahepatic metastases from colorectal cancer. Dis Colon Rectum. 1988 May; 31(5):352-4.
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Pinturo R, Campisi A, Sorrenti V, Di Giacomo C, Gambera G, Castorina C, Vanella A. Ornithine decarboxylase and transglutaminase activities in rat placenta during pregnancy. Acta Eur Fertil. 1988 Jan-Feb; 19(1):45-8.
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Herrera-Ornelas L, Porter C, Pera P, Greco W, Petrelli NJ, Mittelman A. A comparison of ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in human large bowel mucosa, polyps, and colorectal adenocarcinoma. J Surg Res. 1987 Jan; 42(1):56-60.