"Ouabain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
| Descriptor ID |
D010042
|
| MeSH Number(s) |
D04.210.500.155.580.130.750.600 D09.408.180.810.600
|
| Concept/Terms |
Ouabain- Ouabain
- G-Strophanthin
- G Strophanthin
- Acocantherin
- Acolongifloroside K
|
Below are MeSH descriptors whose meaning is more general than "Ouabain".
Below are MeSH descriptors whose meaning is more specific than "Ouabain".
This graph shows the total number of publications written about "Ouabain" by people in this website by year, and whether "Ouabain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ouabain" by people in Profiles.
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Wolle D, Lee SJ, Li Z, Litan A, Barwe SP, Langhans SA. Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma. Cancer Med. 2014 Oct; 3(5):1146-58.
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Sicouri S, Blazek J, Belardinelli L, Antzelevitch C. Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine. Circ Arrhythm Electrophysiol. 2012 Apr; 5(2):371-9.
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Barwe SP, Jordan MC, Skay A, Inge L, Rajasekaran SA, Wolle D, Johnson CL, Neco P, Fang K, Rozengurt N, Goldhaber JI, Roos KP, Rajasekaran AK. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009 Oct; 47(4):552-60.
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Tummala R, Wolle D, Barwe SP, Sampson VB, Rajasekaran AK, Pendyala L. Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin. Cancer Chemother Pharmacol. 2009 Nov; 64(6):1187-94.
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Mandal A, Delamere NA, Shahidullah M. Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C100-10.
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Bollmann A, Husser D. About arrhythmogenic triggers and substrates in aging atria: partners in crime for atrial fibrillation development? J Cardiovasc Electrophysiol. 2007 May; 18(5):532-3.
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Barwe SP, Rajasekaran SA, Rajasekaran AK. Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells. Cell Mol Biol (Noisy-le-grand). 2006 Dec 30; 52(8):41-7.
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Chen JQ, Contreras RG, Wang R, Fernandez SV, Shoshani L, Russo IH, Cereijido M, Russo J. Sodium/potassium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: A new paradigm for development of anti- breast cancer drugs? Breast Cancer Res Treat. 2006 Mar; 96(1):1-15.
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Mason RW, Simpson-Small T, Hopp L. Regulation of 86Rb+ ion transport across polarized human colonocytes by bis-phenolic compounds. Clin Exp Pharmacol Physiol. 2003 Sep; 30(9):623-6.
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Zygmunt AC, Goodrow RJ, Antzelevitch C. I(NaCa) contributes to electrical heterogeneity within the canine ventricle. Am J Physiol Heart Circ Physiol. 2000 May; 278(5):H1671-8.