"Pentoxifylline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
| Descriptor ID |
D010431
|
| MeSH Number(s) |
D03.633.100.759.758.824.651.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pentoxifylline".
Below are MeSH descriptors whose meaning is more specific than "Pentoxifylline".
This graph shows the total number of publications written about "Pentoxifylline" by people in this website by year, and whether "Pentoxifylline" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentoxifylline" by people in Profiles.
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Fritz MA, Arianpour K, Liu SW, Lamarre ED, Genther DJ, Ciolek PJ, Byrne PJ, Prendes BL. Managing Mandibular Osteoradionecrosis. Otolaryngol Head Neck Surg. 2025 Feb; 172(2):406-418.
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Kumar D, Yalamanchali S, New J, Parsel S, New N, Holcomb A, Gunewardena S, Tawfik O, Lominska C, Kimler BF, Anant S, Kakarala K, Tsue T, Shnayder Y, Sykes K, Padhye S, Thomas SM. Development and Characterization of an In Vitro Model for Radiation-Induced Fibrosis. Radiat Res. 2018 03; 189(3):326-336.
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Speer EM, Dowling DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O. Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. Pediatr Res. 2017 May; 81(5):806-816.
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Halegoua-De Marzio DL, Fenkel JM. Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline. JAMA. 2013 Sep 11; 310(10):1029-30.
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Almario B, Wu S, Peng J, Alapati D, Chen S, Sosenko IR. Pentoxifylline and prevention of hyperoxia-induced lung -injury in neonatal rats. Pediatr Res. 2012 May; 71(5):583-9.
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Smith JA, Nunnari G, Preuss M, Pomerantz RJ, Daniel R. Pentoxifylline suppresses transduction by HIV-1-based vectors. Intervirology. 2007; 50(5):377-86.
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Park CH, Scott AW, Fekrat S. Effect of oral pentoxifylline on cystoid macular edema associated with central retinal vein occlusion. Retina. 2007 Oct; 27(8):1020-5.
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Ellm?n J, Hakulinen P, Partanen A, Hayes DF. Estrogenic effects of toremifene and tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res Treat. 2003 Nov; 82(2):103-11.
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Gude RP, Binda MM, Presas HL, Klein-Szanto AJ, Bonfil RD. Studies on the mechanisms responsible for inhibition of experimental metastasis of B16-F10 murine melanoma by pentoxifylline. J Biomed Sci. 1999 Mar-Apr; 6(2):133-41.
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Liedtke W, Cannella B, Mazzaccaro RJ, Clements JM, Miller KM, Wucherpfennig KW, Gearing AJ, Raine CS. Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. Ann Neurol. 1998 Jul; 44(1):35-46.