Prodrugs

"Prodrugs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.

Descriptor ID	D011355
MeSH Number(s)	D26.675
Concept/Terms	Prodrugs Prodrugs Pro-Drugs Pro Drugs Drug Precursors Precursors, Drug

Below are MeSH descriptors whose meaning is more general than "Prodrugs".

Chemicals and Drugs [D]
Pharmaceutical Preparations [D26]
Prodrugs [D26.675]

Below are MeSH descriptors whose meaning is more specific than "Prodrugs".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Prodrugs" by people in this website by year, and whether "Prodrugs" was a major or minor topic of these publications.

Bar chart showing 38 publications over 23 distinct years, with a maximum of 4 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	1	1
1999	2	2	4
2000	1	1	2
2001	1	1	2
2003	0	1	1
2004	0	1	1
2005	1	1	2
2006	2	0	2
2007	0	1	1
2008	0	1	1
2009	1	2	3
2010	1	1	2
2011	0	3	3
2012	1	0	1
2013	1	1	2
2014	1	0	1
2016	0	3	3
2017	0	1	1
2018	0	1	1
2020	1	0	1
2021	1	0	1
2022	1	0	1

Below are the most recent publications written about "Prodrugs" by people in Profiles.

DeFrates KG, Engstr?m J, Sarma NA, Umar A, Shin J, Cheng J, Xie W, Pochan D, Omar AK, Messersmith PB. The influence of molecular design on structure-property relationships of a supramolecular polymer prodrug. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2208593119.

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Barbaraci C, Giurdanella G, Leotta CG, Longo A, Amata E, Dichiara M, Pasquinucci L, Turnaturi R, Prezzavento O, Cacciatore I, Zuccarello E, Lupo G, Pitari GM, Anfuso CD, Marrazzo A. Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. J Med Chem. 2021 09 23; 64(18):13622-13632.

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AbouAitah K, Swiderska-Sroda A, Kandeil A, Salman AMM, Wojnarowicz J, Ali MA, Opalinska A, Gierlotka S, Ciach T, Lojkowski W. Virucidal Action Against Avian Influenza H5N1 Virus and Immunomodulatory Effects of Nanoformulations Consisting of Mesoporous Silica Nanoparticles Loaded with Natural Prodrugs. Int J Nanomedicine. 2020; 15:5181-5202.

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Jain A, Utley L, Parr TR, Zabawa T, Pucci MJ. Tebipenem, the first oral carbapenem antibiotic. Expert Rev Anti Infect Ther. 2018 07; 16(7):513-522.

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Klein-Szanto AJ, Bassi DE. Proprotein convertase inhibition: Paralyzing the cell's master switches. Biochem Pharmacol. 2017 09 15; 140:8-15.

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Edwards JD, Butchbach ME. Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy. J Neuromuscul Dis. 2016 11 29; 3(4):511-515.

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Gibson AK, Shah BM, Nambiar PH, Schafer JJ. Tenofovir Alafenamide. Ann Pharmacother. 2016 11; 50(11):942-952.

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Butchbach MER, Lumpkin CJ, Harris AW, Saieva L, Edwards JD, Workman E, Simard LR, Pellizzoni L, Burghes AHM. Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy. Exp Neurol. 2016 May; 279:13-26.

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Markowitz M, Zolopa A, Squires K, Ruane P, Coakley D, Kearney B, Zhong L, Wulfsohn M, Miller MD, Lee WA. Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults. J Antimicrob Chemother. 2014 May; 69(5):1362-9.

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Garcia AE, Rico MC, Liverani E, DeLa Cadena RA, Bray PF, Kunapuli SP. Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment. PLoS One. 2013; 8(7):e69093.

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